GB1492678A - Guanidine derivatives - Google Patents

Guanidine derivatives

Info

Publication number
GB1492678A
GB1492678A GB33435/75A GB3343575A GB1492678A GB 1492678 A GB1492678 A GB 1492678A GB 33435/75 A GB33435/75 A GB 33435/75A GB 3343575 A GB3343575 A GB 3343575A GB 1492678 A GB1492678 A GB 1492678A
Authority
GB
United Kingdom
Prior art keywords
compounds
bicyclo
rhinoviruses
guanidine derivatives
ncnr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33435/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB33435/75A priority Critical patent/GB1492678A/en
Priority to IE1510/76A priority patent/IE43488B1/en
Priority to CA256,739A priority patent/CA1087180A/en
Priority to ZA764126A priority patent/ZA764126B/en
Priority to AU15956/76A priority patent/AU497534B2/en
Priority to FI762158A priority patent/FI762158A/fi
Priority to PL1976191619A priority patent/PL98956B1/en
Priority to SE7608929A priority patent/SE7608929L/en
Priority to BE169700A priority patent/BE845052A/en
Priority to FR7624440A priority patent/FR2320736A1/en
Priority to DE19762635932 priority patent/DE2635932A1/en
Priority to NO762774A priority patent/NO143993C/en
Priority to CH1019576A priority patent/CH625207A5/en
Priority to AT592976A priority patent/AT351045B/en
Priority to DK362576A priority patent/DK362576A/en
Priority to NL7608903A priority patent/NL7608903A/en
Priority to JP51095896A priority patent/JPS5225743A/en
Publication of GB1492678A publication Critical patent/GB1492678A/en
Priority to AT543478A priority patent/AT352750B/en
Priority to AT543378A priority patent/AT352749B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)

Abstract

The compounds correspond to the formula: <IMAGE> wherein R<1> and R<2> have the meanings given in Claim 1. They are prepared by the action of ammonia on a thiourea R<1>NHC(S)NHR<2> or on a thiouronium salt thereof in the presence of a catalyst or on a carbodiimide R<1>NCNR<2>; resulting bicyclo(2,2,1)-hept-5-enyl compounds can be reduced to the bicyclo(2,2,1)heptanyl compounds. The compounds and their salts have an antiviral activity, especially against rhinoviruses; they can be used for the treatment of rhinovirus infections, as well as for the specific suppression of growth of rhinoviruses in diagnostic investigations and in hospital laboratories.
GB33435/75A 1975-08-11 1975-08-11 Guanidine derivatives Expired GB1492678A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GB33435/75A GB1492678A (en) 1975-08-11 1975-08-11 Guanidine derivatives
IE1510/76A IE43488B1 (en) 1975-08-11 1976-07-08 Guanidine derivatives
CA256,739A CA1087180A (en) 1975-08-11 1976-07-12 Guanidine derivatives
ZA764126A ZA764126B (en) 1975-08-11 1976-07-12 Guanidine derivatives
AU15956/76A AU497534B2 (en) 1975-08-11 1976-07-16 Guanidine derivatives
FI762158A FI762158A (en) 1975-08-11 1976-07-28
PL1976191619A PL98956B1 (en) 1975-08-11 1976-08-04 METHOD OF MAKING NEW GUANIDINE DERIVATIVES
FR7624440A FR2320736A1 (en) 1975-08-11 1976-08-10 GUANIDINE DERIVATIVES
BE169700A BE845052A (en) 1975-08-11 1976-08-10 GUANIDINE DERIVATIVES
SE7608929A SE7608929L (en) 1975-08-11 1976-08-10 GUANIDE INDIVIDUALS AND SET FOR THEIR PREPARATION
DE19762635932 DE2635932A1 (en) 1975-08-11 1976-08-10 GUANIDE DERIVATIVES
NO762774A NO143993C (en) 1975-08-11 1976-08-10 ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMASOYTIC ACTIVE GUANIDINE DERIVATIVES
CH1019576A CH625207A5 (en) 1975-08-11 1976-08-10 Process for the preparation of novel guanidine derivatives
AT592976A AT351045B (en) 1975-08-11 1976-08-10 METHOD FOR PRODUCING NEW GUANIDINE DERIVATIVES AND THEIR ACID ADDITONE SALTS
DK362576A DK362576A (en) 1975-08-11 1976-08-11 GUANIDINE DERIVATIVES
NL7608903A NL7608903A (en) 1975-08-11 1976-08-11 PROCESS FOR THE PREPARATION OF GUANIDINE DERIVATIVES AND PREPARATIONS CONTAINING THEM.
JP51095896A JPS5225743A (en) 1975-08-11 1976-08-11 Guanidine derivatives* process for manufacture thereof and antiviral pharmacological compositions
AT543478A AT352750B (en) 1975-08-11 1978-07-26 PROCESS FOR THE PREPARATION OF NEW GUANIDE DERIVATIVES AND THEIR ACID ADDITION SALTS
AT543378A AT352749B (en) 1975-08-11 1978-07-26 PROCESS FOR THE PREPARATION OF NEW GUANIDE DERIVATIVES AND THEIR ACID ADDITION SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33435/75A GB1492678A (en) 1975-08-11 1975-08-11 Guanidine derivatives

Publications (1)

Publication Number Publication Date
GB1492678A true GB1492678A (en) 1977-11-23

Family

ID=10352924

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33435/75A Expired GB1492678A (en) 1975-08-11 1975-08-11 Guanidine derivatives

Country Status (17)

Country Link
JP (1) JPS5225743A (en)
AT (1) AT351045B (en)
AU (1) AU497534B2 (en)
BE (1) BE845052A (en)
CA (1) CA1087180A (en)
CH (1) CH625207A5 (en)
DE (1) DE2635932A1 (en)
DK (1) DK362576A (en)
FI (1) FI762158A (en)
FR (1) FR2320736A1 (en)
GB (1) GB1492678A (en)
IE (1) IE43488B1 (en)
NL (1) NL7608903A (en)
NO (1) NO143993C (en)
PL (1) PL98956B1 (en)
SE (1) SE7608929L (en)
ZA (1) ZA764126B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984000105A1 (en) * 1982-06-21 1984-01-19 Inst Organicheskogo Sinteza Ak Medicinal preparation having antitumoral effect
US4596823A (en) * 1980-07-01 1986-06-24 National Research Development Corporation Prostaglandins
US4628061A (en) * 1981-12-23 1986-12-09 National Research Development Corporation Prostaglandins
WO2005095345A2 (en) * 2004-03-23 2005-10-13 Achillion Pharmaceuticals, Inc. Heteroaryl guanidines as inhibitors of viral replication

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596823A (en) * 1980-07-01 1986-06-24 National Research Development Corporation Prostaglandins
US4945106A (en) * 1980-07-01 1990-07-31 National Research Development Corporation Prostaglandins
US5025034A (en) * 1980-07-01 1991-06-18 National Research Development Corporation Prostaglandins
US5081282A (en) * 1980-07-01 1992-01-14 National Research Development Corporation Prostaglandins
US4628061A (en) * 1981-12-23 1986-12-09 National Research Development Corporation Prostaglandins
US5006539A (en) * 1981-12-23 1991-04-09 National Research Development Corporation Prostaglandins
WO1984000105A1 (en) * 1982-06-21 1984-01-19 Inst Organicheskogo Sinteza Ak Medicinal preparation having antitumoral effect
WO2005095345A2 (en) * 2004-03-23 2005-10-13 Achillion Pharmaceuticals, Inc. Heteroaryl guanidines as inhibitors of viral replication
WO2005095345A3 (en) * 2004-03-23 2005-12-01 Achillion Pharmaceuticals Inc Heteroaryl guanidines as inhibitors of viral replication

Also Published As

Publication number Publication date
AU497534B2 (en) 1978-12-14
NO143993B (en) 1981-02-16
AU1595676A (en) 1978-01-19
NL7608903A (en) 1977-02-15
IE43488B1 (en) 1981-03-11
NO143993C (en) 1981-05-27
DK362576A (en) 1977-02-12
FI762158A (en) 1977-02-12
AT351045B (en) 1979-07-10
JPS5225743A (en) 1977-02-25
FR2320736A1 (en) 1977-03-11
CA1087180A (en) 1980-10-07
ATA592976A (en) 1978-12-15
DE2635932A1 (en) 1977-03-03
NO762774L (en) 1977-02-14
IE43488L (en) 1977-02-11
BE845052A (en) 1977-02-10
SE7608929L (en) 1977-02-12
ZA764126B (en) 1977-06-29
FR2320736B1 (en) 1980-11-07
CH625207A5 (en) 1981-09-15
PL98956B1 (en) 1978-06-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee