GB1489839A - Purification of 3alpha,7alpha-dihydroxy-5beta-cholanic acid - Google Patents

Purification of 3alpha,7alpha-dihydroxy-5beta-cholanic acid

Info

Publication number
GB1489839A
GB1489839A GB19262/75A GB1926275A GB1489839A GB 1489839 A GB1489839 A GB 1489839A GB 19262/75 A GB19262/75 A GB 19262/75A GB 1926275 A GB1926275 A GB 1926275A GB 1489839 A GB1489839 A GB 1489839A
Authority
GB
United Kingdom
Prior art keywords
chenodeoxycholic acid
dissolution
acid
5beta
7alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19262/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intellectual Property Development Corp Pty Ltd
Original Assignee
Intellectual Property Development Corp Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7401320A external-priority patent/FR2257577B1/fr
Application filed by Intellectual Property Development Corp Pty Ltd filed Critical Intellectual Property Development Corp Pty Ltd
Publication of GB1489839A publication Critical patent/GB1489839A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1489839 Chenodeoxycholic acid INTELLECTUAL PROPERTY DEVELOPMENT CORP 7 May 1975 [7 May 1974] 19262/75 Heading C2U Chenodeoxycholic acid is treated to remove entrapped organic solvent of crystallization, e.g. by (i) dissolution in aqueous alkali and precipitation with acid; or (ii) dissolution in an alcohol and evaporation to dryness; or (iii) drying under vacuum at elevated temperature (e.g. 85-100‹ C./2 mm. Hg). The product has a m.p. of 142-145‹ C. The initial chenodeoxycholic acid is isolated from bile, purified and converted to solvates with ethyl acetate, hexane, heptane and C 5-7 cycloalkanes as described in Specifications 1,450,939 and 1,489,840. Oral compositions for dissolution of cholesterol gallstones comprise chenodeoxycholic acid treated as above and a carrier.
GB19262/75A 1973-12-19 1975-05-07 Purification of 3alpha,7alpha-dihydroxy-5beta-cholanic acid Expired GB1489839A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5881873A GB1450939A (en) 1973-12-19 1973-12-19
DE2400004A DE2400004A1 (en) 1973-12-19 1974-01-02 Pure bile acids isolation - by partitioning bile in a 2-solvent system
FR7401320A FR2257577B1 (en) 1973-11-19 1974-01-15
US46771074A 1974-05-07 1974-05-07

Publications (1)

Publication Number Publication Date
GB1489839A true GB1489839A (en) 1977-10-26

Family

ID=34528009

Family Applications (3)

Application Number Title Priority Date Filing Date
GB5881873A Expired GB1450939A (en) 1972-09-21 1973-12-19
GB14525/77A Expired GB1489840A (en) 1973-12-19 1975-05-07 Inclusion complexes of 3alpha,7alpha-dihydroxy-5beta-cholanic acid
GB19262/75A Expired GB1489839A (en) 1973-12-19 1975-05-07 Purification of 3alpha,7alpha-dihydroxy-5beta-cholanic acid

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB5881873A Expired GB1450939A (en) 1972-09-21 1973-12-19
GB14525/77A Expired GB1489840A (en) 1973-12-19 1975-05-07 Inclusion complexes of 3alpha,7alpha-dihydroxy-5beta-cholanic acid

Country Status (6)

Country Link
JP (1) JPS5129211A (en)
CA (1) CA1032530A (en)
DE (2) DE2400004A1 (en)
FR (1) FR2269957A1 (en)
GB (3) GB1450939A (en)
NL (1) NL7505386A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100658511B1 (en) * 2005-12-12 2006-12-19 주식회사 대웅제약 Purification process for chenodeoxycholic acid
KR100658512B1 (en) * 2005-12-30 2006-12-19 주식회사 대웅제약 Purification process for chenodeoxycholic acid
CN112813128A (en) * 2021-01-12 2021-05-18 中山百灵生物技术股份有限公司 Synthetic method of alloursodeoxycholic acid
CN116789727A (en) * 2021-05-31 2023-09-22 山东海钰生物技术股份有限公司 Production process for extracting chenodeoxycholic acid from chicken bile

Also Published As

Publication number Publication date
NL7505386A (en) 1975-11-11
DE2400004A1 (en) 1975-07-03
GB1489840A (en) 1977-10-26
DE2520488A1 (en) 1975-11-20
FR2269957A1 (en) 1975-12-05
GB1450939A (en) 1976-09-29
JPS5129211A (en) 1976-03-12
CA1032530A (en) 1978-06-06

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee