GB1450939A - - Google Patents

Info

Publication number
GB1450939A
GB1450939A GB5881873A GB5881873A GB1450939A GB 1450939 A GB1450939 A GB 1450939A GB 5881873 A GB5881873 A GB 5881873A GB 5881873 A GB5881873 A GB 5881873A GB 1450939 A GB1450939 A GB 1450939A
Authority
GB
United Kingdom
Prior art keywords
bile
impurities
purified
drying
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5881873A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intellectual Property Co
Original Assignee
Intellectual Property Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA180,969A priority Critical patent/CA1018153A/en
Priority to US417170A priority patent/US3919266A/en
Application filed by Intellectual Property Co filed Critical Intellectual Property Co
Priority to GB5881873A priority patent/GB1450939A/en
Priority to DE2400004A priority patent/DE2400004A1/en
Priority to FR7401320A priority patent/FR2257577B1/fr
Priority claimed from FR7401320A external-priority patent/FR2257577B1/fr
Priority to BE143056A priority patent/BE813549A/en
Priority to US05/547,854 priority patent/US3931256A/en
Priority to CA225,959A priority patent/CA1032530A/en
Priority to NL7505386A priority patent/NL7505386A/en
Priority to GB19262/75A priority patent/GB1489839A/en
Priority to GB14525/77A priority patent/GB1489840A/en
Priority to FR7514427A priority patent/FR2269957A1/fr
Priority to DE19752520488 priority patent/DE2520488A1/en
Priority to JP50055296A priority patent/JPS5129211A/en
Priority to US05/660,037 priority patent/US4014908A/en
Priority to US05/725,086 priority patent/US4072695A/en
Publication of GB1450939A publication Critical patent/GB1450939A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Abstract

1450939 Purifying animal bile INTELLECTUAL PROPERTY DEVELOPMENT CORP 19 Dec 1973 58818/73 Heading A5B [Also in Division C2] Animal bile is purified from pigments and other impurities by the successive steps of (a) dehydration (optionally after mild saponification), e.g. by spray drying, lyophilisation, drum drying, membrane separation or freeze drying; (b) esterification (e.g. with MeOH/H 2 SO 4 or CH 2 N 2 ) either of the impurities only or of both the impurities and the bile acid constituents, in the latter case with subsequent selective hydrolysis of the bile esters; (c) partitioning in a system comprising at least two organic solvents - (lists provided); and (d) separating the phase containing the purified bile. Comparative methods are also disclosed (Exs. I and IV).
GB5881873A 1972-09-21 1973-12-19 Expired GB1450939A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CA180,969A CA1018153A (en) 1972-09-21 1973-09-13 Isolation of bile acids from natural sources
US417170A US3919266A (en) 1972-09-21 1973-11-19 Production of bile acids
GB5881873A GB1450939A (en) 1973-12-19 1973-12-19
DE2400004A DE2400004A1 (en) 1973-12-19 1974-01-02 Pure bile acids isolation - by partitioning bile in a 2-solvent system
FR7401320A FR2257577B1 (en) 1973-11-19 1974-01-15
BE143056A BE813549A (en) 1972-09-21 1974-04-10 PRACTICALLY PURE BILIARY ACID PRODUCTION PROCESSES
US05/547,854 US3931256A (en) 1972-09-21 1975-02-06 Chemical process for production of bile acids
CA225,959A CA1032530A (en) 1973-12-19 1975-04-30 PURIFICATION OF 3.alpha.,7.alpha.-DIHYDROXY-5-.beta.-CHOLANIC ACID
JP50055296A JPS5129211A (en) 1973-12-19 1975-05-07 3 arufuaa 7 arufuaa jihidorokishi 5 beetaa koransannoseiho
NL7505386A NL7505386A (en) 1973-12-19 1975-05-07 PROCESS FOR THE PREPARATION OF BALIC ACIDS.
GB19262/75A GB1489839A (en) 1973-12-19 1975-05-07 Purification of 3alpha,7alpha-dihydroxy-5beta-cholanic acid
GB14525/77A GB1489840A (en) 1973-12-19 1975-05-07 Inclusion complexes of 3alpha,7alpha-dihydroxy-5beta-cholanic acid
FR7514427A FR2269957A1 (en) 1973-12-19 1975-05-07
DE19752520488 DE2520488A1 (en) 1973-12-19 1975-05-07 PROCESS FOR OBTAINING PURE 3ALPHA, 7ALPHA-DIHYDROXY-5BETA-CHOLANIC ACID
US05/660,037 US4014908A (en) 1972-09-21 1976-02-02 Chemical process
US05/725,086 US4072695A (en) 1972-09-21 1976-09-17 3α,7α-Dihydroxy-cholanic acid derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5881873A GB1450939A (en) 1973-12-19 1973-12-19
DE2400004A DE2400004A1 (en) 1973-12-19 1974-01-02 Pure bile acids isolation - by partitioning bile in a 2-solvent system
FR7401320A FR2257577B1 (en) 1973-11-19 1974-01-15
US46771074A 1974-05-07 1974-05-07

Publications (1)

Publication Number Publication Date
GB1450939A true GB1450939A (en) 1976-09-29

Family

ID=34528009

Family Applications (3)

Application Number Title Priority Date Filing Date
GB5881873A Expired GB1450939A (en) 1972-09-21 1973-12-19
GB19262/75A Expired GB1489839A (en) 1973-12-19 1975-05-07 Purification of 3alpha,7alpha-dihydroxy-5beta-cholanic acid
GB14525/77A Expired GB1489840A (en) 1973-12-19 1975-05-07 Inclusion complexes of 3alpha,7alpha-dihydroxy-5beta-cholanic acid

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB19262/75A Expired GB1489839A (en) 1973-12-19 1975-05-07 Purification of 3alpha,7alpha-dihydroxy-5beta-cholanic acid
GB14525/77A Expired GB1489840A (en) 1973-12-19 1975-05-07 Inclusion complexes of 3alpha,7alpha-dihydroxy-5beta-cholanic acid

Country Status (6)

Country Link
JP (1) JPS5129211A (en)
CA (1) CA1032530A (en)
DE (2) DE2400004A1 (en)
FR (1) FR2269957A1 (en)
GB (3) GB1450939A (en)
NL (1) NL7505386A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112813128A (en) * 2021-01-12 2021-05-18 中山百灵生物技术股份有限公司 Synthetic method of alloursodeoxycholic acid
CN113234115A (en) * 2021-05-31 2021-08-10 山东海钰生物技术股份有限公司 Production process for extracting chenodeoxycholic acid from chicken bile

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100658511B1 (en) * 2005-12-12 2006-12-19 주식회사 대웅제약 Purification process for chenodeoxycholic acid
KR100658512B1 (en) * 2005-12-30 2006-12-19 주식회사 대웅제약 Purification process for chenodeoxycholic acid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112813128A (en) * 2021-01-12 2021-05-18 中山百灵生物技术股份有限公司 Synthetic method of alloursodeoxycholic acid
CN113234115A (en) * 2021-05-31 2021-08-10 山东海钰生物技术股份有限公司 Production process for extracting chenodeoxycholic acid from chicken bile

Also Published As

Publication number Publication date
DE2520488A1 (en) 1975-11-20
GB1489839A (en) 1977-10-26
DE2400004A1 (en) 1975-07-03
FR2269957A1 (en) 1975-12-05
GB1489840A (en) 1977-10-26
NL7505386A (en) 1975-11-11
CA1032530A (en) 1978-06-06
JPS5129211A (en) 1976-03-12

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee