JPS6461496A - Production of 5'-ursodeoxycholic acid - Google Patents

Production of 5'-ursodeoxycholic acid

Info

Publication number
JPS6461496A
JPS6461496A JP62214479A JP21447987A JPS6461496A JP S6461496 A JPS6461496 A JP S6461496A JP 62214479 A JP62214479 A JP 62214479A JP 21447987 A JP21447987 A JP 21447987A JP S6461496 A JPS6461496 A JP S6461496A
Authority
JP
Japan
Prior art keywords
acid
lower alkyl
3alpha
oxy
acid lower
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62214479A
Other languages
Japanese (ja)
Other versions
JPH07116221B2 (en
Inventor
Naohiro Kubota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adeka Corp
Original Assignee
Adeka Argus Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adeka Argus Chemical Co Ltd filed Critical Adeka Argus Chemical Co Ltd
Priority to JP62214479A priority Critical patent/JPH07116221B2/en
Publication of JPS6461496A publication Critical patent/JPS6461496A/en
Publication of JPH07116221B2 publication Critical patent/JPH07116221B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE:To obtain the titled substance useful as a cholagogue without through chenodeoxycholic acid, by oxidizing a protected cholic acid lower alkyl ester, esterifying with an organic sulfonic acid ester, treating with an organic amine compound and then hydrogenating. CONSTITUTION:A cholic acid lower alkyl ester [3alpha-R-oxy-7alpha,12alpha- dihydroxycholanic acid lower alkyl ester (R is protecting group)] containing protected OH at the 3-position is oxidized to form 3alpha-R-oxy-7-oxo-12alpha- hydroxycholanic acid lower alkyl. Then the product is esterified with an organic sulfonic acid, the reaction product is treated with an organic amine compound to form a 3alpha-R-oxy-7-oxo-11-cholenic acid lower alkyl. Then this compound is hydrolyzed, selectively reduced and hydrogenated to give ursodeoxycholic acid (3alpha,7beta-dihydroxycholanic acid).
JP62214479A 1987-08-28 1987-08-28 Method for producing ursodeoxycholic acid Expired - Lifetime JPH07116221B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62214479A JPH07116221B2 (en) 1987-08-28 1987-08-28 Method for producing ursodeoxycholic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62214479A JPH07116221B2 (en) 1987-08-28 1987-08-28 Method for producing ursodeoxycholic acid

Publications (2)

Publication Number Publication Date
JPS6461496A true JPS6461496A (en) 1989-03-08
JPH07116221B2 JPH07116221B2 (en) 1995-12-13

Family

ID=16656396

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62214479A Expired - Lifetime JPH07116221B2 (en) 1987-08-28 1987-08-28 Method for producing ursodeoxycholic acid

Country Status (1)

Country Link
JP (1) JPH07116221B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007080951A1 (en) 2006-01-12 2007-07-19 Mitsubishi Chemical Corporation Process for production of steroids
CN106939030A (en) * 2017-04-07 2017-07-11 华东师范大学 A kind of synthetic method of the keto lithcholic acid of intermediate 7 of shellfish cholic acid difficult to understand
CN106995478A (en) * 2017-04-07 2017-08-01 华东师范大学 A kind of synthetic method of the keto lithcholic acid of intermediate 7 of urso
CN107021994A (en) * 2017-04-07 2017-08-08 华东师范大学 A kind of synthetic method of the acid of 5 β cholestane of intermediate 3 α hydroxyls, 7 ketone 24 of shellfish cholic acid difficult to understand
CN107033208A (en) * 2017-04-07 2017-08-11 华东师范大学 A kind of synthetic method of 7 keto lithcholic acid
CN112321665A (en) * 2020-12-01 2021-02-05 江西邦泰绿色生物合成生态产业园发展有限公司 Method for synthesizing 3 alpha, 7 alpha-dihydroxy-5-beta-cholanic acid from duck cholic acid

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007080951A1 (en) 2006-01-12 2007-07-19 Mitsubishi Chemical Corporation Process for production of steroids
CN106939030A (en) * 2017-04-07 2017-07-11 华东师范大学 A kind of synthetic method of the keto lithcholic acid of intermediate 7 of shellfish cholic acid difficult to understand
CN106995478A (en) * 2017-04-07 2017-08-01 华东师范大学 A kind of synthetic method of the keto lithcholic acid of intermediate 7 of urso
CN107021994A (en) * 2017-04-07 2017-08-08 华东师范大学 A kind of synthetic method of the acid of 5 β cholestane of intermediate 3 α hydroxyls, 7 ketone 24 of shellfish cholic acid difficult to understand
CN107033208A (en) * 2017-04-07 2017-08-11 华东师范大学 A kind of synthetic method of 7 keto lithcholic acid
CN112321665A (en) * 2020-12-01 2021-02-05 江西邦泰绿色生物合成生态产业园发展有限公司 Method for synthesizing 3 alpha, 7 alpha-dihydroxy-5-beta-cholanic acid from duck cholic acid

Also Published As

Publication number Publication date
JPH07116221B2 (en) 1995-12-13

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