GB1480637A - 2-hydroxynicotinic acid derivative and methods of preparing same - Google Patents

2-hydroxynicotinic acid derivative and methods of preparing same

Info

Publication number
GB1480637A
GB1480637A GB41018/74A GB4101874A GB1480637A GB 1480637 A GB1480637 A GB 1480637A GB 41018/74 A GB41018/74 A GB 41018/74A GB 4101874 A GB4101874 A GB 4101874A GB 1480637 A GB1480637 A GB 1480637A
Authority
GB
United Kingdom
Prior art keywords
formula
dimethylaniline
methods
hydroxynicotinic acid
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41018/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Hermes SA
Original Assignee
Laboratorios Hermes SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Hermes SA filed Critical Laboratorios Hermes SA
Publication of GB1480637A publication Critical patent/GB1480637A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1480637 2<SP>1</SP>,6<SP>1</SP>-Dimethylanilide of 2-hydroxynicotinic acid LABORATORIOS HERMES SA 20 Sept 1974 [20 July 1974] 41018/74 Heading C2C The novel title compound of Formula I is obtained (a) by reacting a halonicotinic acid of formula wherein X is a halogen atom with 2,6-dimethylaniline or (b) by reacting a compound of formula wherein Z is a halogen atom or the group -CO-Z is an ester group, with 2,6-dimethylaniline to form the intermediate of formula and then hydrolysing the latter with an alkali metal or alkaline earth metal hydroxide. The condensations are preferably effected with heating in the presence of a solvent using a stoichiometric excess of 2,6-dimethylaniline and the hydrolysis preferably in a polar solvent (e.g. DMF, DMSO) at >120‹C. The total compound possesses analgesic and anti-inflammatory properties.
GB41018/74A 1974-07-20 1974-09-20 2-hydroxynicotinic acid derivative and methods of preparing same Expired GB1480637A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES428449A ES428449A1 (en) 1974-07-20 1974-07-20 2-hydroxynicotinic acid derivative and methods of preparing same

Publications (1)

Publication Number Publication Date
GB1480637A true GB1480637A (en) 1977-07-20

Family

ID=8467178

Family Applications (1)

Application Number Title Priority Date Filing Date
GB41018/74A Expired GB1480637A (en) 1974-07-20 1974-09-20 2-hydroxynicotinic acid derivative and methods of preparing same

Country Status (7)

Country Link
JP (1) JPS5176279A (en)
BE (1) BE820578A (en)
DE (1) DE2461653B2 (en)
ES (1) ES428449A1 (en)
FR (1) FR2278685A1 (en)
GB (1) GB1480637A (en)
IT (1) IT1049428B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973597A (en) * 1989-06-30 1990-11-27 Eli Lilly And Company Anticonvulsant agents

Also Published As

Publication number Publication date
JPS5521747B2 (en) 1980-06-12
BE820578A (en) 1975-01-16
FR2278685A1 (en) 1976-02-13
DE2461653A1 (en) 1976-01-29
JPS5176279A (en) 1976-07-01
FR2278685B1 (en) 1979-02-16
DE2461653B2 (en) 1978-08-31
ES428449A1 (en) 1976-08-16
IT1049428B (en) 1981-01-20
DE2461653C3 (en) 1979-04-26

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee
728C Application made for restoration (sect. 28/1977)
728P Application not proceeded with (sect. 28/1977)