GB1414752A - Process for the preparation of diamino-pteridyl-methyl- methylamino-benzoyl-glutamic acid derivative - Google Patents
Process for the preparation of diamino-pteridyl-methyl- methylamino-benzoyl-glutamic acid derivativeInfo
- Publication number
- GB1414752A GB1414752A GB1246574A GB1246574A GB1414752A GB 1414752 A GB1414752 A GB 1414752A GB 1246574 A GB1246574 A GB 1246574A GB 1246574 A GB1246574 A GB 1246574A GB 1414752 A GB1414752 A GB 1414752A
- Authority
- GB
- United Kingdom
- Prior art keywords
- diamino
- glutamic acid
- pteridyl
- methylamino
- benzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1414752 {[(diaminopteridyl)methyl]methylamino}benzoylglutamic acid INSTITUTUL ONCOLOGIC 20 March 1974 12465/74 Heading C2C N - [p - {[(2,4 - diamino - 6 - pteridyl)methylmethylamino}benzoyl]-glutamic acid is prepared by (i) treating a salt of 2,4,5,6-tetraaminopyridine with 1,3-dihydroxyacetone bisulphite in aqueous media with air-bubbling and in the presence of a thio-alcohol as catalyst (preferably cysteine) and an oxidation agent (preferably selenium dixide (ii) reacting 2,4-diamino-6- hydroxymethylpteridine obtained with a halogenation agent preferably thionyl chloride or phosphorus oxychloride) in an inert media (preferably chloroform or methylene chloride) in the presence of a basic catalyst (preferably pyridine or triethylamine) to form the 6-halomethyl derivative and (iii) condensing this compound with N-[p-methylaminobenzoyl]-glutaric acid in buffered aqueous media. The D, L or racemate compound is prepared by using the appropriate glutamic acid in stage (iii).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1246574A GB1414752A (en) | 1974-03-20 | 1974-03-20 | Process for the preparation of diamino-pteridyl-methyl- methylamino-benzoyl-glutamic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1246574A GB1414752A (en) | 1974-03-20 | 1974-03-20 | Process for the preparation of diamino-pteridyl-methyl- methylamino-benzoyl-glutamic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1414752A true GB1414752A (en) | 1975-11-19 |
Family
ID=10005112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1246574A Expired GB1414752A (en) | 1974-03-20 | 1974-03-20 | Process for the preparation of diamino-pteridyl-methyl- methylamino-benzoyl-glutamic acid derivative |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1414752A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0048002A2 (en) * | 1980-09-12 | 1982-03-24 | Farmos Group Ltd. | Method for preparing N-(4-(((2,4-diamino-6-pteridinyl)-methyl)methylamino)benzoyl)glutamic acid |
WO1997021711A1 (en) * | 1995-12-12 | 1997-06-19 | Lonza Ag | Process for preparing 4-aminopteridine derivatives |
-
1974
- 1974-03-20 GB GB1246574A patent/GB1414752A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0048002A2 (en) * | 1980-09-12 | 1982-03-24 | Farmos Group Ltd. | Method for preparing N-(4-(((2,4-diamino-6-pteridinyl)-methyl)methylamino)benzoyl)glutamic acid |
EP0048002A3 (en) * | 1980-09-12 | 1982-06-23 | Farmos Group Ltd. | Method for preparing n-(4-(((2,4-diamino-6-pteridinyl)-methyl)methylamino)benzoyl)glutamic acid |
WO1997021711A1 (en) * | 1995-12-12 | 1997-06-19 | Lonza Ag | Process for preparing 4-aminopteridine derivatives |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |