GB1478553A - Tetrapeptide amide and acid addition salts thereof - Google Patents
Tetrapeptide amide and acid addition salts thereofInfo
- Publication number
- GB1478553A GB1478553A GB35358/75A GB3535875A GB1478553A GB 1478553 A GB1478553 A GB 1478553A GB 35358/75 A GB35358/75 A GB 35358/75A GB 3535875 A GB3535875 A GB 3535875A GB 1478553 A GB1478553 A GB 1478553A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prolyl
- alaninamide
- benzyloxycarbonyl
- alanine
- methyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- -1 t-butyl- Oxycarbonyl Chemical group 0.000 abstract 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000005984 hydrogenation reaction Methods 0.000 abstract 3
- 101000655609 Streptomyces azureus Thiostrepton Proteins 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 2
- ZQEBQGAAWMOMAI-ZETCQYMHSA-N (2s)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1C(O)=O ZQEBQGAAWMOMAI-ZETCQYMHSA-N 0.000 abstract 1
- JXGVXCZADZNAMJ-NSHDSACASA-N (2s)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCN1C(=O)OCC1=CC=CC=C1 JXGVXCZADZNAMJ-NSHDSACASA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1172574 | 1974-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1478553A true GB1478553A (en) | 1977-07-06 |
Family
ID=4376294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35358/75A Expired GB1478553A (en) | 1974-08-28 | 1975-08-27 | Tetrapeptide amide and acid addition salts thereof |
Country Status (16)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066749A (en) * | 1977-01-24 | 1978-01-03 | Merck & Co., Inc. | Tetrapeptide analog of TRH |
| US4215110A (en) * | 1978-09-22 | 1980-07-29 | Merck & Co., Inc. | Method of treating hypertension |
| DE2905502C2 (de) * | 1979-02-14 | 1982-07-15 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von LH-RH bzw. LH-RH-Analoga und Pyroglutamyl-N↑i↑m↑-dinitrophenyl-histidin |
| JPH0684013B2 (ja) * | 1985-10-09 | 1994-10-26 | 大日本印刷株式会社 | 成形機における樹脂供給装置 |
-
1975
- 1975-07-22 ZA ZA00754724A patent/ZA754724B/xx unknown
- 1975-07-24 IL IL47796A patent/IL47796A0/xx unknown
- 1975-07-31 AU AU83567/75A patent/AU8356775A/en not_active Expired
- 1975-08-20 DE DE19752537071 patent/DE2537071A1/de active Pending
- 1975-08-22 NL NL7509958A patent/NL7509958A/xx not_active Application Discontinuation
- 1975-08-26 FR FR7526266A patent/FR2282907A1/fr not_active Withdrawn
- 1975-08-26 DD DD188033A patent/DD123314A5/xx unknown
- 1975-08-26 LU LU73258A patent/LU73258A1/xx unknown
- 1975-08-26 JP JP50102636A patent/JPS5148662A/ja active Pending
- 1975-08-27 IE IE1875/75A patent/IE41605B1/en unknown
- 1975-08-27 GB GB35358/75A patent/GB1478553A/en not_active Expired
- 1975-08-27 DK DK386275A patent/DK386275A/da unknown
- 1975-08-27 FI FI752409A patent/FI752409A7/fi not_active Application Discontinuation
- 1975-08-27 SE SE7509532A patent/SE7509532L/xx unknown
- 1975-08-27 NO NO752947A patent/NO752947L/no unknown
- 1975-08-27 BE BE159494A patent/BE832783A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2282907A1 (fr) | 1976-03-26 |
| JPS5148662A (enrdf_load_stackoverflow) | 1976-04-26 |
| IL47796A0 (en) | 1975-10-15 |
| NO752947L (enrdf_load_stackoverflow) | 1976-03-02 |
| DK386275A (da) | 1976-02-29 |
| NL7509958A (nl) | 1976-03-02 |
| BE832783A (fr) | 1976-02-27 |
| SE7509532L (sv) | 1976-03-01 |
| DD123314A5 (enrdf_load_stackoverflow) | 1976-12-12 |
| ZA754724B (en) | 1976-06-30 |
| LU73258A1 (enrdf_load_stackoverflow) | 1977-04-15 |
| DE2537071A1 (de) | 1976-03-18 |
| IE41605B1 (en) | 1980-02-13 |
| AU8356775A (en) | 1977-02-03 |
| IE41605L (en) | 1976-02-28 |
| FI752409A7 (enrdf_load_stackoverflow) | 1976-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |