GB1477635A - Dibenzazepines - Google Patents

Dibenzazepines

Info

Publication number
GB1477635A
GB1477635A GB4024273A GB4024273A GB1477635A GB 1477635 A GB1477635 A GB 1477635A GB 4024273 A GB4024273 A GB 4024273A GB 4024273 A GB4024273 A GB 4024273A GB 1477635 A GB1477635 A GB 1477635A
Authority
GB
United Kingdom
Prior art keywords
alkyl
followed
aug
reacting
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4024273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RES INST FOR MEDICINE CHEMISTR
Original Assignee
RES INST FOR MEDICINE CHEMISTR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RES INST FOR MEDICINE CHEMISTR filed Critical RES INST FOR MEDICINE CHEMISTR
Priority to GB4024273A priority Critical patent/GB1477635A/en
Priority to AR255294A priority patent/AR206406A1/en
Priority to JP49096243A priority patent/JPS5070385A/ja
Priority to DK450474A priority patent/DK450474A/da
Priority to BE147842A priority patent/BE819121A/en
Priority to SE7410753A priority patent/SE7410753L/xx
Priority to DE2440592A priority patent/DE2440592A1/en
Priority to PH16200A priority patent/PH10437A/en
Priority to CH1152774A priority patent/CH602658A5/xx
Priority to NO743036A priority patent/NO743036L/no
Priority to ZA00745421A priority patent/ZA745421B/en
Priority to CA207,647A priority patent/CA1042887A/en
Priority to IL45522A priority patent/IL45522A/en
Priority to FR7428988A priority patent/FR2241319B1/fr
Priority to NL7411235A priority patent/NL7411235A/en
Priority to US05/793,772 priority patent/US4181655A/en
Publication of GB1477635A publication Critical patent/GB1477635A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

1477635 Dibenzazepines RESEARCH INSTITUTE FOR MEDICINE & CHEMISTRY Inc 23 Aug 1974 [24 Aug 1973] 40242/73 Heading C2C Compounds of the general formula (R<SP>1,2</SP>=H, alkyl; R<SP>3</SP> = alkyl, optionally substituted, R<SP>4</SP>=H or alkyl, optionally substituted, or NR<SP>3</SP>R<SP>4</SP>=heterocyclic group; the dibenzazepine nucleus optionally carrying one or more substituents selected from halogen, alkyl, alkoxy, alkylthio in position(s) 2, 3, 7 and/or 8 and their acid addition salts are prepared by (a) reacting the 5-unsubstituted compound or an alkali metal derivative thereof with (X=reactive ester radical; R<SP>7</SP> = NR<SP>3</SP>R<SP>4</SP> or substituent convertible into or replaceable by such a group), followed by conversion of R<SP>7</SP> to NR<SP>3</SP>R<SP>4</SP> if necessary, or (b) reducing the corresponding compound containing a keto group in the 1-position of the 5-substituent, optionally followed by salt formation in either case. The starting materials are prepared by reacting a 5 - acyl - 5H - dibenz[b,f]azepiae (obtained by acylation) with trifluoromethyl hypofluorite followed by dehydrofluorination and, if necessary, deacylation. The above compounds are antidepressants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB4024273A 1973-08-24 1973-08-24 Dibenzazepines Expired GB1477635A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB4024273A GB1477635A (en) 1973-08-24 1973-08-24 Dibenzazepines
AR255294A AR206406A1 (en) 1973-08-24 1974-01-01 PROCEDURE FOR PREPARING DERIVATIVES OF 5- (3'AMINOPROP-1'-IL) -10-TRIFLUOROMETOXI-5H-DIBENZ (B, F) ACEPIN
JP49096243A JPS5070385A (en) 1973-08-24 1974-08-23
DK450474A DK450474A (en) 1973-08-24 1974-08-23
BE147842A BE819121A (en) 1973-08-24 1974-08-23 NEW DIBENZAZEPINES WITH ANTI-DEPRESSIVE ACTIVITY
SE7410753A SE7410753L (en) 1973-08-24 1974-08-23
DE2440592A DE2440592A1 (en) 1973-08-24 1974-08-23 DIBENZAZEPINE
PH16200A PH10437A (en) 1973-08-24 1974-08-23 5-(3'-aminoprop-1'-yl)-10-trifluoromethoxy-5h dibenz(b-f)azepines and pharmaceutical compositions thereof
CH1152774A CH602658A5 (en) 1973-08-24 1974-08-23
NO743036A NO743036L (en) 1973-08-24 1974-08-23
ZA00745421A ZA745421B (en) 1973-08-24 1974-08-23 Novel dibenzazepines having antidepressant activity
CA207,647A CA1042887A (en) 1973-08-24 1974-08-23 Trifluoromethoxy dibenzodiazepine derivatives
IL45522A IL45522A (en) 1973-08-24 1974-08-23 5-(3'-aminoprop-1'-yl)-10-trifluoromethoxy-5h-dibenz(b,f) azepines,their preparation and pharmaceutical compositions containing them
FR7428988A FR2241319B1 (en) 1973-08-24 1974-08-23
NL7411235A NL7411235A (en) 1973-08-24 1974-08-23 PROCESS FOR THE PREPARATION OF DIBENZAZEPINE DERIVATIVES.
US05/793,772 US4181655A (en) 1973-08-24 1977-05-04 5(3-Substituted aminopropyl)-10-trifluoromethoxy-5H-dibenz[b,f]azepines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4024273A GB1477635A (en) 1973-08-24 1973-08-24 Dibenzazepines

Publications (1)

Publication Number Publication Date
GB1477635A true GB1477635A (en) 1977-06-22

Family

ID=10413924

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4024273A Expired GB1477635A (en) 1973-08-24 1973-08-24 Dibenzazepines

Country Status (15)

Country Link
JP (1) JPS5070385A (en)
AR (1) AR206406A1 (en)
BE (1) BE819121A (en)
CA (1) CA1042887A (en)
CH (1) CH602658A5 (en)
DE (1) DE2440592A1 (en)
DK (1) DK450474A (en)
FR (1) FR2241319B1 (en)
GB (1) GB1477635A (en)
IL (1) IL45522A (en)
NL (1) NL7411235A (en)
NO (1) NO743036L (en)
PH (1) PH10437A (en)
SE (1) SE7410753L (en)
ZA (1) ZA745421B (en)

Also Published As

Publication number Publication date
ZA745421B (en) 1976-05-26
DK450474A (en) 1975-04-28
CA1042887A (en) 1978-11-21
FR2241319A1 (en) 1975-03-21
FR2241319B1 (en) 1978-08-11
NL7411235A (en) 1975-02-26
IL45522A (en) 1979-01-31
AR206406A1 (en) 1976-07-23
JPS5070385A (en) 1975-06-11
CH602658A5 (en) 1978-07-31
SE7410753L (en) 1975-02-25
IL45522A0 (en) 1974-11-29
BE819121A (en) 1975-02-24
PH10437A (en) 1977-03-21
DE2440592A1 (en) 1975-03-13
NO743036L (en) 1975-03-24

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee