GB1477020A - Method for the preparation of 3,5-disubstituted pyrazoles - Google Patents
Method for the preparation of 3,5-disubstituted pyrazolesInfo
- Publication number
- GB1477020A GB1477020A GB3603874A GB3603874A GB1477020A GB 1477020 A GB1477020 A GB 1477020A GB 3603874 A GB3603874 A GB 3603874A GB 3603874 A GB3603874 A GB 3603874A GB 1477020 A GB1477020 A GB 1477020A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- preparation
- alkyl
- carbon
- pyrazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 3,5-disubstituted pyrazoles Chemical class 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- JXHKUYQCEJILEI-UHFFFAOYSA-N 3,5-diphenyl-1h-pyrazole Chemical compound C=1C(C=2C=CC=CC=2)=NNC=1C1=CC=CC=C1 JXHKUYQCEJILEI-UHFFFAOYSA-N 0.000 abstract 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- JGDFBJMWFLXCLJ-UHFFFAOYSA-N copper chromite Chemical compound [Cu]=O.[Cu]=O.O=[Cr]O[Cr]=O JGDFBJMWFLXCLJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003219 pyrazolines Chemical class 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39828473A | 1973-09-17 | 1973-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1477020A true GB1477020A (en) | 1977-06-22 |
Family
ID=23574783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3603874A Expired GB1477020A (en) | 1973-09-17 | 1974-08-15 | Method for the preparation of 3,5-disubstituted pyrazoles |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS5855143B2 (enExample) |
| AR (1) | AR225264A1 (enExample) |
| AT (1) | AT339893B (enExample) |
| BE (1) | BE819948A (enExample) |
| BR (1) | BR7407147D0 (enExample) |
| CA (1) | CA1037048A (enExample) |
| CH (1) | CH596185A5 (enExample) |
| CS (1) | CS178177B2 (enExample) |
| DD (1) | DD115667A5 (enExample) |
| DE (1) | DE2441504A1 (enExample) |
| DK (1) | DK134643B (enExample) |
| ES (1) | ES430129A1 (enExample) |
| FR (1) | FR2243943B1 (enExample) |
| GB (1) | GB1477020A (enExample) |
| IL (1) | IL45399A (enExample) |
| IT (1) | IT1029578B (enExample) |
| NL (1) | NL168832C (enExample) |
| SE (1) | SE416648B (enExample) |
| SU (1) | SU645567A3 (enExample) |
| ZA (1) | ZA744908B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4424364A (en) | 1980-08-01 | 1984-01-03 | Basf Aktiengesellschaft | Preparation of pyrazoles |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910949A (en) * | 1974-12-09 | 1975-10-07 | American Cyanamid Co | Manufacture of 1,2-dimethyl-3,5-diphenylpyrazolium methylsulfate in a single reaction zone |
| NZ216253A (en) * | 1985-05-27 | 1989-07-27 | Mitsui Toatsu Chemicals | N-(3-chloro-4-isopropylphenyl)-carboxamide derivatives and herbicidal compositions |
| USRE39708E1 (en) | 1998-08-07 | 2007-06-26 | Chiron Corporation | Estrogen receptor modulators |
| WO2000007996A2 (en) * | 1998-08-07 | 2000-02-17 | Chiron Corporation | Pyrazoles as estrogen receptor modulators |
| JP2002522425A (ja) | 1998-08-07 | 2002-07-23 | カイロン コーポレイション | エストロゲンレセプターモジュレーターとしての置換イソオキサゾール |
| JP5063351B2 (ja) * | 2004-09-17 | 2012-10-31 | エグゼリクシス， インコーポレイテッド | ピラゾールキナーゼモジュレーターおよび使用方法 |
| DK2307381T3 (da) * | 2008-06-09 | 2021-03-15 | Univ Muenchen Ludwig Maximilians | Nye lægemidler til inhibering af aggregering af proteiner involveret i sygdomme forbundet med proteinaggregering og/eller neurodegenerative sygdomme |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2260485C2 (de) * | 1971-12-17 | 1983-12-29 | American Cyanamid Co., Wayne, N.J. | 1,2-Dialkyl-3,5-diphenylpyrazoliumsalze und diese enthaltende herbizide Mittel |
| DE3209148A1 (de) * | 1982-03-13 | 1983-09-22 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von pyrazolen durch katalytische dehydrierung von pyrazolinen |
-
1974
- 1974-07-31 ZA ZA00744908A patent/ZA744908B/xx unknown
- 1974-08-04 IL IL45399A patent/IL45399A/xx unknown
- 1974-08-15 GB GB3603874A patent/GB1477020A/en not_active Expired
- 1974-08-22 CA CA207,577A patent/CA1037048A/en not_active Expired
- 1974-08-22 AR AR255275A patent/AR225264A1/es active
- 1974-08-28 BR BR7147/74A patent/BR7407147D0/pt unknown
- 1974-08-30 DE DE2441504A patent/DE2441504A1/de active Granted
- 1974-09-06 IT IT52913/74A patent/IT1029578B/it active
- 1974-09-11 CH CH1237174A patent/CH596185A5/xx not_active IP Right Cessation
- 1974-09-11 DD DD181031A patent/DD115667A5/xx unknown
- 1974-09-12 AT AT738174A patent/AT339893B/de not_active IP Right Cessation
- 1974-09-12 NL NLAANVRAGE7412119,A patent/NL168832C/xx not_active IP Right Cessation
- 1974-09-16 DK DK487274AA patent/DK134643B/da not_active IP Right Cessation
- 1974-09-16 FR FR7431248A patent/FR2243943B1/fr not_active Expired
- 1974-09-16 SU SU742059902A patent/SU645567A3/ru active
- 1974-09-16 CS CS6341A patent/CS178177B2/cs unknown
- 1974-09-16 SE SE7411650A patent/SE416648B/xx not_active IP Right Cessation
- 1974-09-16 BE BE148556A patent/BE819948A/xx not_active IP Right Cessation
- 1974-09-17 ES ES430129A patent/ES430129A1/es not_active Expired
- 1974-09-17 JP JP49107068A patent/JPS5855143B2/ja not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4424364A (en) | 1980-08-01 | 1984-01-03 | Basf Aktiengesellschaft | Preparation of pyrazoles |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2243943B1 (enExample) | 1986-07-04 |
| FR2243943A1 (enExample) | 1975-04-11 |
| SE7411650L (enExample) | 1975-03-18 |
| SE416648B (sv) | 1981-01-26 |
| DK134643B (da) | 1976-12-13 |
| CS178177B2 (enExample) | 1977-08-31 |
| NL168832B (nl) | 1981-12-16 |
| NL168832C (nl) | 1982-05-17 |
| CA1037048A (en) | 1978-08-22 |
| ES430129A1 (es) | 1977-01-16 |
| DK134643C (enExample) | 1977-05-16 |
| IL45399A0 (en) | 1974-11-29 |
| DD115667A5 (enExample) | 1975-10-12 |
| DK487274A (enExample) | 1975-05-12 |
| ZA744908B (en) | 1975-08-27 |
| CH596185A5 (enExample) | 1978-03-15 |
| IT1029578B (it) | 1979-03-20 |
| AR225264A1 (es) | 1982-03-15 |
| BE819948A (fr) | 1975-03-17 |
| JPS5058068A (enExample) | 1975-05-20 |
| JPS5855143B2 (ja) | 1983-12-08 |
| NL7412119A (nl) | 1975-03-19 |
| ATA738174A (de) | 1977-03-15 |
| IL45399A (en) | 1979-01-31 |
| AU7202874A (en) | 1976-03-11 |
| DE2441504C2 (enExample) | 1987-11-26 |
| DE2441504A1 (de) | 1975-03-20 |
| AT339893B (de) | 1977-11-10 |
| SU645567A3 (ru) | 1979-01-30 |
| BR7407147D0 (pt) | 1975-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Baciocchi et al. | Synthesis of 3-acyl and 3-carboalkoxyfurans by the ceric ammonium nitrate promoted addition of 1, 3-dicarbonyl compounds to vinylic acetates | |
| GB1477020A (en) | Method for the preparation of 3,5-disubstituted pyrazoles | |
| ES317146A1 (es) | Procedimiento para la obtencion de compuestos triaza biciclicos. | |
| Habraken et al. | Heterocyclic Studies. XVI. The Assignment of Isomeric and Tautomeric Structures of Pyrazoles by Nuclear Magnetic Resonance*, 1a, b | |
| Freeman et al. | Synthesis, structure, and synthetic utility of thallium (I) tricyanovinylcyclopentadienide | |
| Ibata et al. | Reaction of diazo ketones in the presence of metal chelates. VII. 1, 3-Dipolar cycloaddition of 1-methoxybenzo [c] pyrylium-4-olate with acetylenic dipolarophiles. | |
| Kume et al. | Synthesis of 3-aryl-or 3-alkenyl-4, 6-dimethyl-2-pyrones by silver ion promoted rearrangement of 4-aryl-or4-alkenyl-3-bromo-4, 6-dimethyl-3, 4-dihydro-2-pyrones | |
| Balachandran et al. | Oxidation with metal oxides—VIII: Oxidation of bisphenylhydrazones of 1, 2-diketones with nickel peroxide | |
| KR940021525A (ko) | 수성 니코틴알데히드의 제조방법 | |
| Buzykin et al. | Reaction of azines with 5-pyrazolones | |
| Okamoto et al. | Steric hindrance under high pressure. Reactions of 2, 4, 6-tri-tert-butyl-N-methylaniline with alkyl iodides | |
| SE7411889L (enExample) | ||
| Hearn et al. | Reactions of N‐aminophthalimide with electrophiles. II. Preparation and properties of araldehyde hydrazones | |
| Mikol et al. | Isocarbostyrils from monomeric and dimeric. beta.-styryl isocyanates | |
| TAMURA et al. | Cycloaddition to 1, 3-dialkoxycarbonylallenes: one-step synthesis of heterocyclic compounds containing a dialkyl glutaconate structure | |
| GB1446135A (en) | Process for preparation of a palladium complex compound | |
| GB1412527A (en) | Method for the preparation of phthalqzino o2,3-b phthalazine-5 14h, 12 7h-dione | |
| Gainsford et al. | Photochemistry of azole N-oxides. III. Photoinduced ring expansion of 2H-1, 2, 3-Triazole N-oxides | |
| US3682914A (en) | 2,6-diphenyl-4,5-dihydro-3(2h)-pyridizinone derivatives | |
| GB921322A (en) | Substituted hydrazide compounds | |
| Saito et al. | Reactions of sodium salts of tosylhydrazone compounds with silver chromate. Formation of indazole, pyrazole, and benzonitrile derivatives. | |
| GB1346378A (en) | 2-stilbenyl-4-styryl-v-triazoles their use for the optical brightening of organic materials and processes for their manufacture | |
| UTSUMI et al. | On the Radical Species produced by the Reaction of L-Ascorbic Acid and It's Analogs with Hydrazine and It's Derivatives | |
| Fǎrcaşiu | Syntheses of pyrylium salts by hydride transfer from 1, 5-diketones to triphenylmethyl hexachloroantimonate generated in situ | |
| Ioffe et al. | Isomeric composition of pyrazolines obtained from unsaturated carbonyl compounds and hydrazine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19930815 |