GB1476422A - Biological extracts - Google Patents

Biological extracts

Info

Publication number
GB1476422A
GB1476422A GB914973A GB914973A GB1476422A GB 1476422 A GB1476422 A GB 1476422A GB 914973 A GB914973 A GB 914973A GB 914973 A GB914973 A GB 914973A GB 1476422 A GB1476422 A GB 1476422A
Authority
GB
United Kingdom
Prior art keywords
glycopeptide
infra
cells
immunostimulating
red
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB914973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB914973A priority Critical patent/GB1476422A/en
Priority to HU74WE501A priority patent/HU173676B/en
Priority to IE367/74A priority patent/IE39332B1/en
Priority to BE141321A priority patent/BE811491A/en
Priority to US05/445,309 priority patent/US4010257A/en
Priority to JP49021333A priority patent/JPS5063196A/ja
Priority to CA193,265A priority patent/CA1020460A/en
Priority to CH257874A priority patent/CH602920A5/xx
Priority to ZA00741189A priority patent/ZA741189B/en
Priority to IL44267A priority patent/IL44267A/en
Priority to DE19742408724 priority patent/DE2408724A1/en
Priority to NL7402455A priority patent/NL7402455A/xx
Priority to FR7406104A priority patent/FR2218888B1/fr
Priority to AU65910/74A priority patent/AU6591074A/en
Priority to DK96174AA priority patent/DK141757B/en
Priority to US05/588,313 priority patent/US4069314A/en
Publication of GB1476422A publication Critical patent/GB1476422A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1476422 Immunostimulating glycopeptide WELLCOME FOUNDATION Ltd 23 May 1974 [23 Feb 1973 14 Feb 1974] 9149/73 and 6759/74 Heading A5B [Also in Division C3] An immunostimulating glycopeptide capable of conferring on mammals and birds a resistance to tumours and pathogens is obtained from cell wall material of an immunostimulating bacterium of the Actinomycetaceae Family of Prevots classification. Bacteria specified include Corynebacterium parvum, C. anaerobium, C. granulosum, C. liquifaciens, C. pyogenes, C. lymphophilum, C. hepatodystrophicans, C. adamsoni, C. avidium, C. diphtheroides, C. renale cuniculi, C. acnes, C. equi and C. ovis. The glycopeptide is extracted by (a) culturing the bacteria, (b) harvesting the cells and (c) treating the cells with a biphasic extraction solvent comprising water and a phenol so as to yield the glycopeptide as an insoluble residue. The cells are generally subjected to lysis before extraction with the biphasic solvent. The glycopeptide may be recovered by centrifugation. The product is substantially insoluble in water, saline, methanol, ethanol, phenol, chloroform, dioxan, pyridine, dimethylformamide, diethylene glycol and hexane, has infra-red peptide absorption at 1550 and 1660 cm<SP>-1</SP>, infra-red carbohydrate absorption between 950 and 1100 cm<SP>-1</SP> with peak between 1050 and 1070 cm<SP>-1</SP>, has substantially no infra-red lipid absorption between 2850 and 2950 cm<SP>-1</SP> and after intravenous administration increases the liver and spleen weight of mice and increases the life expectancy of mice with tumours. The glycopeptide is combined with a carrier for use.
GB914973A 1973-02-23 1973-02-23 Biological extracts Expired GB1476422A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB914973A GB1476422A (en) 1973-02-23 1973-02-23 Biological extracts
HU74WE501A HU173676B (en) 1973-02-23 1974-02-22 Process for producing glycopeptides
IE367/74A IE39332B1 (en) 1973-02-23 1974-02-22 Biological extracts
BE141321A BE811491A (en) 1973-02-23 1974-02-22 ORGANIC EXTRACTS
US05/445,309 US4010257A (en) 1973-02-23 1974-02-22 Biological extracts
JP49021333A JPS5063196A (en) 1973-02-23 1974-02-22
CA193,265A CA1020460A (en) 1973-02-23 1974-02-22 Isolation of immunostimulating glycopeptide from bacteria
CH257874A CH602920A5 (en) 1973-02-23 1974-02-22
ZA00741189A ZA741189B (en) 1973-02-23 1974-02-22 Biological extracts
IL44267A IL44267A (en) 1973-02-23 1974-02-22 Glycopeptides, their preparation and pharmaceutical compositions containing them
DE19742408724 DE2408724A1 (en) 1973-02-23 1974-02-22 BIOLOGICAL EXTRACTS AND METHOD FOR PRODUCING THEM
NL7402455A NL7402455A (en) 1973-02-23 1974-02-22
FR7406104A FR2218888B1 (en) 1973-02-23 1974-02-22
AU65910/74A AU6591074A (en) 1973-02-23 1974-02-22 Glycoprotein from bacteria
DK96174AA DK141757B (en) 1973-02-23 1974-02-22 Method for Preparing an Immunostimulatory Glycopeptide from Corynebacterium parvum.
US05/588,313 US4069314A (en) 1973-02-23 1975-06-19 Glycopeptide extract

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB914973A GB1476422A (en) 1973-02-23 1973-02-23 Biological extracts

Publications (1)

Publication Number Publication Date
GB1476422A true GB1476422A (en) 1977-06-16

Family

ID=9866339

Family Applications (1)

Application Number Title Priority Date Filing Date
GB914973A Expired GB1476422A (en) 1973-02-23 1973-02-23 Biological extracts

Country Status (12)

Country Link
JP (1) JPS5063196A (en)
AU (1) AU6591074A (en)
BE (1) BE811491A (en)
DE (1) DE2408724A1 (en)
DK (1) DK141757B (en)
FR (1) FR2218888B1 (en)
GB (1) GB1476422A (en)
HU (1) HU173676B (en)
IE (1) IE39332B1 (en)
IL (1) IL44267A (en)
NL (1) NL7402455A (en)
ZA (1) ZA741189B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024941A2 (en) * 1979-08-30 1981-03-11 Yamanouchi Pharmaceutical Co., Ltd. Water-soluble extract from nonpathogenic aerobic corynebacteria, production thereof and compositions containing the extract
WO2016009377A1 (en) * 2014-07-16 2016-01-21 Depofarma S.P.A. Propionibacterium acnes and granulosum parietal fraction having immunomodulating action

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410476B1 (en) * 1977-11-30 1980-08-22 Inst Nat Sante Rech Med APPLICATION OF PEPTIDOGLYCANS EXTRACTED FROM BACTERIA, PARTICULARLY BACILLUS AS MEDICAMENTS, ESPECIALLY STIMULATING ANTI-TUMOR IMMUNITY
FR2480604A1 (en) * 1980-04-22 1981-10-23 Pasteur Institut Aerobic bacterial fractions, esp. Corynebacterium catarrhalis - are medicaments with adjuvant, immunostimulant, antibacterial and interferon-inducing activity
US4479935A (en) * 1980-04-22 1984-10-30 Institut Pasteur Fractions extracted from aerobic bacteria, endowed with antitumoral, antibacterial and interferon inducing properties, and process for their preparation
FR2502496A2 (en) * 1981-03-30 1982-10-01 Pasteur Institut Aerobic bacterial fractions, esp. Corynebacterium catarrhalis - are medicaments with adjuvant, immunostimulant, antibacterial and interferon-inducing activity
US4871488A (en) * 1985-04-22 1989-10-03 Albany Medical College Of Union University Reconstituting viral glycoproteins into large phospholipid vesicles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450815A (en) * 1964-04-24 1969-06-17 Princeton Lab Inc Method of stimulating a host defense mechanism with an actinovaccine
US3529057A (en) * 1964-08-14 1970-09-15 Takeda Chemical Industries Ltd Purified periodic acid-oxidized mucopeptide of mycobacteria cell walls constituting a vaccine enhancing nonspecific host resistance against pathogenic bacterial infections

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024941A2 (en) * 1979-08-30 1981-03-11 Yamanouchi Pharmaceutical Co., Ltd. Water-soluble extract from nonpathogenic aerobic corynebacteria, production thereof and compositions containing the extract
EP0024941A3 (en) * 1979-08-30 1981-12-02 Yamanouchi Pharmaceutical Co. Ltd. Water-soluble extract from nonpathogenic aerobic corynebacteria, production thereof and compositions containing the extract
WO2016009377A1 (en) * 2014-07-16 2016-01-21 Depofarma S.P.A. Propionibacterium acnes and granulosum parietal fraction having immunomodulating action
JP2017526382A (en) * 2014-07-16 2017-09-14 デポファルマ ソチエタ ペル アツィオニＤｅｐｏｆａｒｍａ Ｓ．Ｐ．Ａ． Cell wall fraction of Propionibacterium acnes and Propionibacterium granulosum with immunomodulatory action
US10576109B2 (en) 2014-07-16 2020-03-03 Depofarma S.P.A. Propionibacterium acnes and granulosum parietal fraction having immunomodulating action

Also Published As

Publication number Publication date
BE811491A (en) 1974-08-22
ZA741189B (en) 1975-09-24
AU6591074A (en) 1975-08-28
FR2218888B1 (en) 1976-12-03
JPS5063196A (en) 1975-05-29
FR2218888A1 (en) 1974-09-20
IE39332B1 (en) 1978-09-13
IL44267A (en) 1978-07-31
NL7402455A (en) 1974-08-27
DK141757B (en) 1980-06-09
HU173676B (en) 1979-07-28
DE2408724A1 (en) 1974-09-05
DK141757C (en) 1980-10-27
IE39332L (en) 1974-08-23
IL44267A0 (en) 1974-05-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee