GB1472870A - Process for preparing cephalosporins - Google Patents

Process for preparing cephalosporins

Info

Publication number
GB1472870A
GB1472870A GB2841076A GB2841076A GB1472870A GB 1472870 A GB1472870 A GB 1472870A GB 2841076 A GB2841076 A GB 2841076A GB 2841076 A GB2841076 A GB 2841076A GB 1472870 A GB1472870 A GB 1472870A
Authority
GB
United Kingdom
Prior art keywords
alkyl
base
inorganic
residue
suitably
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2841076A
Inventor
Maurizio Foglio
Giovanni Franceschi
Paolo Masi
Antonino Suarato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB1472870A publication Critical patent/GB1472870A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Document Processing Apparatus (AREA)

Abstract

1472870 Cephalosporin synthesis SOC FARMACEUTICI ITALIA SpA 20 May 1975 [22 May 1974] 28410/76 Divided out of 1472865 Heading C2C A process for the preparation of a cephalosporin having the general formula comprises treating a thiohydrazoazetidine of the formula wherein R is hydrogen, (C 1 -C 4 )alkyl, cyanomethyl, thienylmethyl, furylmethyl, naphthylmethyl, benzyl, phenoxymethyl, phenylisopropyl, phenoxyisopropyl, 4 - pyridyl - 4 thiomethyl or 1-tetrazolyl-methyl; R<SP>2</SP> and R<SP>3</SP> represent (C 1 -C 4 )alkyl, a mononuclear aryl or heterocyclic group, cyano, -COR<SP>4</SP>, -COOR<SP>4</SP>, -PO(OR<SP>4</SP>) 2 or -CONHR<SP>4</SP> in which R<SP>4</SP> is (C 1 -C 4 )alkyl or a mononuclear aryl or heterocyclic group; or R<SP>2</SP> and R<SP>3</SP> together represent a residue of any of the formulae Y is a residue of the formula and Z is hydrogen, bromine, iodine, hydroxyl, alkanoyloxy, alkyloxy, azido, amino, acetoxy, carbamate or an S-mononuclear nitrogen heterocyclic ring with an organic or inorganic base or an inorganic basic or weakly acid oxide at a temperature of from -100‹ to + 120‹ C. The inorganic oxide is suitably Al 2 O 3 , Fe 2 O 3 , Cr 2 O 3 or SiO 2 , and the base is suitably Na 2 CO 3 , NH 4 OH an alkali or alkaline earth metal hydroxide, an alkali metal alcoholate, an aliphatic, aromatic or heterocyclic amine, an alkylammonium base or a basic resin.
GB2841076A 1974-05-22 1975-05-20 Process for preparing cephalosporins Expired GB1472870A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23070/74A IT1043958B (en) 1974-05-22 1974-05-22 PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINE

Publications (1)

Publication Number Publication Date
GB1472870A true GB1472870A (en) 1977-05-11

Family

ID=11203454

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2841076A Expired GB1472870A (en) 1974-05-22 1975-05-20 Process for preparing cephalosporins
GB2141975A Expired GB1472865A (en) 1974-05-22 1975-05-20 Process for preparing thiohydrozoazetidiones

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2141975A Expired GB1472865A (en) 1974-05-22 1975-05-20 Process for preparing thiohydrozoazetidiones

Country Status (16)

Country Link
JP (1) JPS50160291A (en)
AT (1) AT340047B (en)
BE (1) BE829304A (en)
CA (1) CA1055485A (en)
DE (1) DE2522142A1 (en)
DK (1) DK220375A (en)
ES (1) ES437842A1 (en)
FR (1) FR2279753A1 (en)
GB (2) GB1472870A (en)
HU (1) HU171357B (en)
IT (1) IT1043958B (en)
NL (1) NL170286C (en)
NO (1) NO751781L (en)
SE (1) SE7505751L (en)
SU (1) SU727147A3 (en)
ZA (1) ZA753244B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1472866A (en) 1974-06-12 1977-05-11 Farmaceutici Italia Cephalosporins and intermediates therefor
NL7806860A (en) * 1977-07-05 1979-01-09 Farmaceutici Italia PROCESS FOR PREPARING NOCARDICIN-RELATED AZETIDINONES.
US4482491A (en) * 1981-05-01 1984-11-13 Otsuka Kagaku Yakuhin Kabushiki Kaisha Thiazolinoazetidinone derivatives and process for the preparation of the same
EP0088488B1 (en) * 1982-01-22 1986-10-01 Beecham Group Plc Antibacterial agents, their preparation and use

Also Published As

Publication number Publication date
SE7505751L (en) 1975-11-24
DE2522142A1 (en) 1975-12-11
NO751781L (en) 1975-11-25
AT340047B (en) 1977-11-25
FR2279753A1 (en) 1976-02-20
SU727147A3 (en) 1980-04-05
NL170286C (en) 1982-10-18
BE829304A (en) 1975-11-21
NL7505800A (en) 1975-11-25
JPS50160291A (en) 1975-12-25
HU171357B (en) 1977-12-28
IT1043958B (en) 1980-02-29
DK220375A (en) 1975-11-23
ES437842A1 (en) 1977-01-01
NL170286B (en) 1982-05-17
ZA753244B (en) 1976-05-26
GB1472865A (en) 1977-05-11
ATA376875A (en) 1977-03-15
AU8131975A (en) 1976-11-25
FR2279753B1 (en) 1979-03-16
CA1055485A (en) 1979-05-29

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee