GB1470030A - Optical resolution of 1-t-butylamino-2,3-dihydroxy-propane - Google Patents
Optical resolution of 1-t-butylamino-2,3-dihydroxy-propaneInfo
- Publication number
- GB1470030A GB1470030A GB5063275A GB5063275A GB1470030A GB 1470030 A GB1470030 A GB 1470030A GB 5063275 A GB5063275 A GB 5063275A GB 5063275 A GB5063275 A GB 5063275A GB 1470030 A GB1470030 A GB 1470030A
- Authority
- GB
- United Kingdom
- Prior art keywords
- butylamino
- dihydroxypropane
- diastereoisomer
- solution
- optical resolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1470030 Optical resolution of 1-t-butylamino- 2,3-dihydroxypropane MERCK & CO Inc 10 Dec 1975 [13 Dec 1974 25 Sept 1975] 50632/75 Heading C2C Mixtures of enantiomers of 1-t-butylamino- 2,3-dihydroxypropane are optically resolved by (1) treating a solution of the mixture with a resolving agent selected from S-pyroglutamic acid, R-pyroglutamic acid, L-tartaric acid and D-tartaric acid (2) separating from the solution the solid diastereoisomer which forms and (3) recovering from the diastereoisomer a single enantiomer of 1-t-butylamino-2,3-dihydroxypropane, e.g. by treating it with a base or running a solution of the diastereoisomer through an ion-exchange resin. The initial mixture of enantiomers of 1-t-butylamino-2,3-dihydroxypropane may be made by reacting t-butylamine with glycidol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53254774A | 1974-12-13 | 1974-12-13 | |
US61594175A | 1975-09-25 | 1975-09-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1470030A true GB1470030A (en) | 1977-04-14 |
Family
ID=27063872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5063275A Expired GB1470030A (en) | 1974-12-13 | 1975-12-10 | Optical resolution of 1-t-butylamino-2,3-dihydroxy-propane |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS51118711A (en) |
AU (1) | AU510799B2 (en) |
CA (1) | CA1064943A (en) |
DE (1) | DE2556040C2 (en) |
DK (1) | DK532575A (en) |
FR (2) | FR2294151A1 (en) |
GB (1) | GB1470030A (en) |
IE (1) | IE42206B1 (en) |
NL (1) | NL7513818A (en) |
SE (1) | SE435499B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588694A (en) * | 1982-08-13 | 1986-05-13 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for production of optically active oxazolidinone derivative |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01149775A (en) * | 1987-12-07 | 1989-06-12 | Kawaken Fine Chem Co Ltd | Production of optically active 2-methylpiperazine |
US5684159A (en) * | 1995-05-30 | 1997-11-04 | Rhone-Poulenc Rorer S.A. | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
IN187238B (en) * | 1995-06-30 | 2002-03-09 | Astra Ab | |
CN109311801B (en) * | 2016-03-25 | 2022-07-26 | 美国政府健康及人类服务部 | Crystal forms and synthesis methods of (2R,6R) -hydroxynorketamine and (2S,6S) -hydroxynorketamine |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2528267A (en) * | 1950-10-31 | Eobeet j | ||
US3116332A (en) * | 1958-10-17 | 1963-12-31 | Du Pont | Resolution of racemic aminoisopropanol |
-
1975
- 1975-11-26 DK DK532575A patent/DK532575A/en not_active Application Discontinuation
- 1975-11-26 SE SE7513307A patent/SE435499B/en not_active IP Right Cessation
- 1975-11-26 NL NL7513818A patent/NL7513818A/en active Search and Examination
- 1975-12-03 AU AU87220/75A patent/AU510799B2/en not_active Expired
- 1975-12-08 CA CA241,257A patent/CA1064943A/en not_active Expired
- 1975-12-09 FR FR7537575A patent/FR2294151A1/en active Granted
- 1975-12-10 GB GB5063275A patent/GB1470030A/en not_active Expired
- 1975-12-11 IE IE2702/75A patent/IE42206B1/en unknown
- 1975-12-12 DE DE2556040A patent/DE2556040C2/en not_active Expired
- 1975-12-12 JP JP50147481A patent/JPS51118711A/en active Pending
-
1976
- 1976-05-04 FR FR7613241A patent/FR2303790A1/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588694A (en) * | 1982-08-13 | 1986-05-13 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for production of optically active oxazolidinone derivative |
Also Published As
Publication number | Publication date |
---|---|
SE435499B (en) | 1984-10-01 |
FR2303790B1 (en) | 1980-07-18 |
JPS51118711A (en) | 1976-10-18 |
FR2294151A1 (en) | 1976-07-09 |
CA1064943A (en) | 1979-10-23 |
DE2556040A1 (en) | 1976-06-16 |
SE7513307L (en) | 1976-06-14 |
AU510799B2 (en) | 1980-07-17 |
FR2303790A1 (en) | 1976-10-08 |
FR2294151B1 (en) | 1979-04-06 |
IE42206B1 (en) | 1980-06-18 |
NL7513818A (en) | 1976-06-15 |
DK532575A (en) | 1976-06-14 |
AU8722075A (en) | 1977-06-09 |
IE42206L (en) | 1976-06-13 |
DE2556040C2 (en) | 1986-05-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 19951209 |