GB1462718A - Digoxin complexes - Google Patents
Digoxin complexesInfo
- Publication number
- GB1462718A GB1462718A GB2853174A GB2853174A GB1462718A GB 1462718 A GB1462718 A GB 1462718A GB 2853174 A GB2853174 A GB 2853174A GB 2853174 A GB2853174 A GB 2853174A GB 1462718 A GB1462718 A GB 1462718A
- Authority
- GB
- United Kingdom
- Prior art keywords
- digoxin
- complex
- complexes
- dihydroxybenzene
- june
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical class C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 abstract 3
- 229960005156 digoxin Drugs 0.000 abstract 3
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 abstract 3
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 abstract 1
- 230000002821 anti-nucleating effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- DQYBDCGIPTYXML-UHFFFAOYSA-N ethoxyethane;hydrate Chemical compound O.CCOCC DQYBDCGIPTYXML-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 abstract 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C07J19/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00375052A US3839317A (en) | 1973-06-29 | 1973-06-29 | Digoxin complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1462718A true GB1462718A (en) | 1977-01-26 |
Family
ID=23479300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2853174A Expired GB1462718A (en) | 1973-06-29 | 1974-06-27 | Digoxin complexes |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3839317A (xx) |
| JP (1) | JPS538768B2 (xx) |
| CA (1) | CA1024980A (xx) |
| FR (1) | FR2234899B1 (xx) |
| GB (1) | GB1462718A (xx) |
| SE (2) | SE402112B (xx) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1503388A (en) * | 1975-07-01 | 1978-03-08 | Inverni Della Beffa Spa | Pharmaceutically active complexes and pharmaceutical compositions containing them |
| JPS5948414A (ja) * | 1982-09-10 | 1984-03-19 | Asahi Denka Kogyo Kk | ビタミンｅの水溶性製剤 |
| JPH02139531U (xx) * | 1989-04-26 | 1990-11-21 | ||
| EP0677171B1 (en) * | 1993-11-04 | 2000-03-29 | Dade Behring Inc. | Tetrahydroxyquinone as an activator component for activated partial thromboplastine time test of blood coagulation and as a detector of blood coagulation disorders |
| CN114177152A (zh) * | 2021-12-16 | 2022-03-15 | 北京微智瑞医药科技有限公司 | 一种地高辛微片及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1075251A (en) * | 1962-10-04 | 1967-07-12 | Wellcombe Foundation Ltd | Cardenolide derivatives |
| FR1441429A (fr) * | 1964-10-08 | 1966-06-10 | Searle & Co | Procédé pour séparer la gamma-lactone de l'acide 3-(3-oxo-17beta-hydroxy-4, 6-androstadièn-17alpha-yl)-propionique de ses solutions |
| US3531462A (en) * | 1967-05-19 | 1970-09-29 | Shionogi Seiyaku Kk | Carbonates of cardenolide tridigitoxosides and ester derivatives thereof |
-
1973
- 1973-06-29 US US00375052A patent/US3839317A/en not_active Expired - Lifetime
-
1974
- 1974-06-27 GB GB2853174A patent/GB1462718A/en not_active Expired
- 1974-06-27 FR FR7422522A patent/FR2234899B1/fr not_active Expired
- 1974-06-28 SE SE7408554A patent/SE402112B/xx unknown
- 1974-06-28 CA CA203,751A patent/CA1024980A/en not_active Expired
- 1974-06-29 JP JP7489974A patent/JPS538768B2/ja not_active Expired
-
1977
- 1977-05-20 SE SE7705958A patent/SE7705958L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5069217A (xx) | 1975-06-10 |
| FR2234899B1 (xx) | 1977-05-06 |
| FR2234899A1 (xx) | 1975-01-24 |
| JPS538768B2 (xx) | 1978-03-31 |
| SE402112B (sv) | 1978-06-19 |
| CA1024980A (en) | 1978-01-24 |
| SE7408554L (xx) | 1974-12-30 |
| US3839317A (en) | 1974-10-01 |
| AU7065874A (en) | 1976-01-08 |
| DE2430850A1 (de) | 1975-03-06 |
| DE2430850B2 (de) | 1977-06-08 |
| SE7705958L (sv) | 1977-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |