GB1461240A - Cycloaliphatic derivatives of 3,3-diphenyl-propylamine - Google Patents
Cycloaliphatic derivatives of 3,3-diphenyl-propylamineInfo
- Publication number
- GB1461240A GB1461240A GB2041575A GB2041575A GB1461240A GB 1461240 A GB1461240 A GB 1461240A GB 2041575 A GB2041575 A GB 2041575A GB 2041575 A GB2041575 A GB 2041575A GB 1461240 A GB1461240 A GB 1461240A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- carbon atoms
- reaction
- compound
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1461240 3,3-Diphenylpropylamine derivatives MAGGIONI & C SpA 14 May 1975 [15 May 1974] 20415/75 Heading C2C Novel compounds of Formula I wherein X is lower alkyl; R is lower alkyl or cycloalkyl having up to 8 carbon atoms and optionally substituted with alkyl having up to 4 carbon atoms, cycloalkyl having up to 6 carbon atoms or phenyl, with the proviso that when R is lower alkyl optionally substituted, R and X optionally unite together to make up a cycloaliphatic ring having from 5 to 7 carbon atoms; and acid addition salts thereof are prepared by reaction of a compound of Formula II with a compound of Formula IV and reducing the azomethinic compound in situ or by reaction of 3,3-diphenylpropionic acid with an amine of Formula V and reduction of the amide so formed or by reaction of a 3,3-diphenyl-1-halopropane with the above amine of Formula V The novel compounds have vasodilating activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2270974 | 1974-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1461240A true GB1461240A (en) | 1977-01-13 |
Family
ID=11199496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2041575A Expired GB1461240A (en) | 1974-05-15 | 1975-05-14 | Cycloaliphatic derivatives of 3,3-diphenyl-propylamine |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5123248A (en) |
| DE (1) | DE2521113A1 (en) |
| FR (1) | FR2270853B1 (en) |
| GB (1) | GB1461240A (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2482956A1 (en) * | 1980-05-22 | 1981-11-27 | Synthelabo | Cardiovascular phenyl or cycloalkyl-cyclohexyl-alkylamine derivs. - which increase coronary flow but not cardiac work e.g. n-alpha-methyl-beta-phenyl:ethyl 2-cyclohexyl 2-phenyl ethylamine |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| AU2003250483A1 (en) | 2002-08-19 | 2004-03-11 | Pfizer Products Inc. | Combination therapy for hyperproliferative diseases |
| DE602004016123D1 (en) | 2003-03-07 | 2008-10-09 | Schering Corp | SUBSTITUTED AZETIDINONE DERIVATIVES, THEIR PHARMACEUTICAL FORMULATIONS AND THEIR USE FOR THE TREATMENT OF HYPERCHOLESTEROLMIA |
| ATE418551T1 (en) | 2003-03-07 | 2009-01-15 | Schering Corp | SUBSTITUTED AZETIDINONE DERIVATIVES, THEIR PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF HYPERCHOLESTEROLEMIA |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| JP5498168B2 (en) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | N-((3-Benzyl) -2,2- (bis-phenyl) -propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular disease |
| EA020466B1 (en) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| JP2016516804A (en) | 2013-04-17 | 2016-06-09 | ファイザー・インク | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| CN113388007A (en) | 2013-06-05 | 2021-09-14 | 博士医疗爱尔兰有限公司 | Ultra-pure agonists of guanylate cyclase C, methods of making and using the same |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| JOP20210193A1 (en) | 2019-01-18 | 2023-01-30 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
-
1975
- 1975-05-13 DE DE19752521113 patent/DE2521113A1/en not_active Withdrawn
- 1975-05-14 GB GB2041575A patent/GB1461240A/en not_active Expired
- 1975-05-14 JP JP5621775A patent/JPS5123248A/en active Pending
- 1975-05-15 FR FR7515190A patent/FR2270853B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2521113A1 (en) | 1976-03-18 |
| FR2270853A1 (en) | 1975-12-12 |
| FR2270853B1 (en) | 1978-09-08 |
| JPS5123248A (en) | 1976-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |