GB1460471A - 5h-1-benzopyrano 4,3-c- pyridines - Google Patents

5h-1-benzopyrano 4,3-c- pyridines

Info

Publication number
GB1460471A
GB1460471A GB3107574A GB3107574A GB1460471A GB 1460471 A GB1460471 A GB 1460471A GB 3107574 A GB3107574 A GB 3107574A GB 3107574 A GB3107574 A GB 3107574A GB 1460471 A GB1460471 A GB 1460471A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
july
benzopyrano
pyridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3107574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US379016A external-priority patent/US3878219A/en
Priority claimed from US05/458,744 external-priority patent/US4254116A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB1460471A publication Critical patent/GB1460471A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1460471 Benzopyrano[4,3-c]pyridines ABBOTT LABORATORIES 12 July 1974 [13 July 1973 8 April 1974] 31075/74 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable salts, wherein R 1 is C 1-6 alkyl; R 2 is C 1-6 alkyl substituted by C 3-7 cycloalkyl, or C 1-20 alkyl, or Ph-C 1-10 -alkyl (in which Ph may contain up to 3 of halogen, CF 3 and C 1-6 alkyl substituents); R 3 is OH, acyloxy, up to C 6 alkoxy, alkenyloxy or alkynyloxy, or R 7 R 8 N-C 1-8 alkyl-COO, where R 7 and R 8 are each H or C 1-6 alkyl, or NR 7 R 8 forms a saturated heterocyclic group (as defined in the Specification). The compounds where R 3 = OH are prepared by dehydrogenation of the 1,2,3,4-tetrahydro-analogue (with simultaneous hydrogenolysis of a 2-benzyl group if present), and may then be etherified or esterified. Therapeutic compositions having analgesic, anti-anxiety and anti-depressant activity comprise compounds of the above formula, and may be administered orally, parenterally or rectally.
GB3107574A 1973-07-13 1974-07-12 5h-1-benzopyrano 4,3-c- pyridines Expired GB1460471A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US379016A US3878219A (en) 1973-07-13 1973-07-13 5H-{8 1{9 benzopyrano{8 3,4-d{9 pyridines
US05/458,744 US4254116A (en) 1974-04-08 1974-04-08 5H-[1]Benzopyrano[3,4-d]pyridines

Publications (1)

Publication Number Publication Date
GB1460471A true GB1460471A (en) 1977-01-06

Family

ID=27008438

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3107574A Expired GB1460471A (en) 1973-07-13 1974-07-12 5h-1-benzopyrano 4,3-c- pyridines

Country Status (10)

Country Link
JP (1) JPS5315519B2 (en)
CA (1) CA1037955A (en)
CH (1) CH592667A5 (en)
DE (1) DE2433442A1 (en)
DK (2) DK328674A (en)
FR (1) FR2236496B1 (en)
GB (1) GB1460471A (en)
NL (1) NL7408851A (en)
PH (1) PH13729A (en)
SE (1) SE401511B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576798A (en) * 1965-09-27 1971-04-27 Little Inc A 1,2,3,4-tetrahydro-5h-(1)benzopyrano (3,4-d)pyridines
US3991194A (en) * 1971-12-27 1976-11-09 Sharps Associates Heterocyclic esters of benzopyranopyridines

Also Published As

Publication number Publication date
JPS5315519B2 (en) 1978-05-25
NL7408851A (en) 1975-01-15
PH13729A (en) 1980-09-09
DK579082A (en) 1982-12-30
DK328674A (en) 1975-03-17
DE2433442A1 (en) 1975-01-30
SE7409098L (en) 1975-01-14
AU7004074A (en) 1975-12-18
JPS5040596A (en) 1975-04-14
FR2236496A1 (en) 1975-02-07
SE401511B (en) 1978-05-16
FR2236496B1 (en) 1977-09-09
CH592667A5 (en) 1977-10-31
CA1037955A (en) 1978-09-05

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee