GB1458537A - - Google Patents
Info
- Publication number
- GB1458537A GB1458537A GB5820273A GB5820273A GB1458537A GB 1458537 A GB1458537 A GB 1458537A GB 5820273 A GB5820273 A GB 5820273A GB 5820273 A GB5820273 A GB 5820273A GB 1458537 A GB1458537 A GB 1458537A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- acid
- reaction
- amino
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- SZOLUXDHHKCYKT-UHFFFAOYSA-N but-1-en-1-amine Chemical compound CCC=CN SZOLUXDHHKCYKT-UHFFFAOYSA-N 0.000 abstract 2
- QNRMTGGDHLBXQZ-UHFFFAOYSA-N buta-1,2-diene Chemical compound CC=C=C QNRMTGGDHLBXQZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical class C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 150000002905 orthoesters Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003138 primary alcohols Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 saturated heterocyclic amides Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5820273A GB1458537A (enrdf_load_stackoverflow) | 1973-12-15 | 1973-12-15 | |
| IE2440/74A IE40251B1 (en) | 1973-12-15 | 1974-11-27 | Derivatives of butanoic and butenoic acids |
| AU76155/74A AU7615574A (en) | 1973-12-15 | 1974-12-06 | Derivatives of butanoic and butenoic acids |
| ZA00747769A ZA747769B (en) | 1973-12-15 | 1974-12-06 | Derivatives of butanoic and butenoic acids |
| US05/531,556 US3998965A (en) | 1973-12-15 | 1974-12-11 | 4-Aminoalkyl-4-cyano-4-phenyl-butanoic acid esters |
| NL7416161A NL7416161A (nl) | 1973-12-15 | 1974-12-12 | Werkwijze voor de bereiding van geneesmiddelen met een werking op het centrale zenuwstelsel of met cardiovasculaire werking, gevormd geneesmid- del met een dergelijke werking en werkwijze voor de bereiding van de geneeskrachtige verbindingen. |
| BE151436A BE823272A (fr) | 1973-12-15 | 1974-12-12 | Derives d'acides butanoique et d'acide butenoique |
| DK652274A DK652274A (enrdf_load_stackoverflow) | 1973-12-15 | 1974-12-13 | |
| DE19742459077 DE2459077A1 (de) | 1973-12-15 | 1974-12-13 | Alkylester, dialkylamide und gesaettigte heterocyclische amide der 4-aminoalkyl-4-cyano-4-phenyl-butan- und -but- 2-ensaeuren |
| JP49144360A JPS5089343A (enrdf_load_stackoverflow) | 1973-12-15 | 1974-12-16 | |
| FR7441315A FR2254329A1 (enrdf_load_stackoverflow) | 1973-12-15 | 1974-12-16 | |
| US05/679,165 US4035497A (en) | 1972-12-28 | 1976-04-22 | Butanoic and butenoic acid morpholides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5820273A GB1458537A (enrdf_load_stackoverflow) | 1973-12-15 | 1973-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1458537A true GB1458537A (enrdf_load_stackoverflow) | 1976-12-15 |
Family
ID=10481022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5820273A Expired GB1458537A (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-15 |
Country Status (10)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007031737A1 (en) * | 2005-09-14 | 2007-03-22 | Prestwick Pharmaceuticals, Inc. | 4,4-dimethylpiperidine-2,6-dione derivatives for use in the treatment of hypertension |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4639524A (en) * | 1984-07-09 | 1987-01-27 | G. D. Searle & Co. | Monobasic disobutamide derivatives |
-
1973
- 1973-12-15 GB GB5820273A patent/GB1458537A/en not_active Expired
-
1974
- 1974-11-27 IE IE2440/74A patent/IE40251B1/xx unknown
- 1974-12-06 AU AU76155/74A patent/AU7615574A/en not_active Expired
- 1974-12-06 ZA ZA00747769A patent/ZA747769B/xx unknown
- 1974-12-12 NL NL7416161A patent/NL7416161A/xx unknown
- 1974-12-12 BE BE151436A patent/BE823272A/xx unknown
- 1974-12-13 DE DE19742459077 patent/DE2459077A1/de active Pending
- 1974-12-13 DK DK652274A patent/DK652274A/da not_active Application Discontinuation
- 1974-12-16 FR FR7441315A patent/FR2254329A1/fr not_active Withdrawn
- 1974-12-16 JP JP49144360A patent/JPS5089343A/ja active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007031737A1 (en) * | 2005-09-14 | 2007-03-22 | Prestwick Pharmaceuticals, Inc. | 4,4-dimethylpiperidine-2,6-dione derivatives for use in the treatment of hypertension |
| GB2445888A (en) * | 2005-09-14 | 2008-07-23 | Prestwick Pharmaceuticals Inc | 4,4-dimethylpiperidine-2, 6-dione derivatives for use in the treatment of hypertension |
| GB2445888B (en) * | 2005-09-14 | 2010-01-06 | Prestwick Pharmaceuticals Inc | Treatment of hypertension |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5089343A (enrdf_load_stackoverflow) | 1975-07-17 |
| IE40251B1 (en) | 1979-04-11 |
| IE40251L (en) | 1975-06-15 |
| BE823272A (fr) | 1975-06-12 |
| DE2459077A1 (de) | 1975-07-03 |
| ZA747769B (en) | 1976-08-25 |
| AU7615574A (en) | 1976-06-10 |
| FR2254329A1 (enrdf_load_stackoverflow) | 1975-07-11 |
| NL7416161A (nl) | 1975-06-17 |
| DK652274A (enrdf_load_stackoverflow) | 1975-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES418924A1 (es) | Procedimiento para la obtencion de 13, 14-dihidroprosta- glandinas. | |
| GB1285400A (en) | Esters of substituted anthranilic acid | |
| GB1415412A (en) | Perfluoroalkyl compounds process for their manufacture and their use | |
| GB1131498A (en) | Niconitic acid esters | |
| GB1458537A (enrdf_load_stackoverflow) | ||
| GB1304925A (enrdf_load_stackoverflow) | ||
| GB1472132A (en) | Cyclopentanone triesters and process therefor | |
| GB1496492A (en) | Optically active lysergic acid derivatives | |
| ES433049A1 (es) | Procedimiento para la preparacion de nuevos esteroides de laserie del estrano. | |
| GB1424415A (en) | Prostaglandin intermediates and their preparation | |
| ES427115A1 (es) | Procedimiento de preparacion de nuevos derivados del acido acetico. | |
| GB1410853A (en) | Pharmaceutically useful prostaglandin derivatives | |
| GB1448758A (en) | Thiazole derivatives | |
| ES425088A1 (es) | Procedimiento para preparar resinas acidas. | |
| ES402670A1 (es) | Un procedimiento para la preparacion de nuevos acidos ben- zamidoacetohidroxamicos. | |
| GB1236947A (en) | Process for the preparation of piperazine derivatives | |
| GB1421580A (en) | Production of benzylamine derivatives | |
| GB1366666A (en) | Tricyclic compounds and the preparation thereof | |
| GB847779A (en) | 2-(4-biphenylyl)-í¸-hexenoic acid esters thereof | |
| GB1144829A (en) | Tricyclic derivatives of acetamide | |
| SE7408053L (enrdf_load_stackoverflow) | ||
| ES426296A1 (es) | Procedimiento para la preparacion de acidos trialcoxiben- zoilaminocarboxilicos sulfurados. | |
| GB1361379A (en) | Process for the preparation of ypsilon-aryloxyacetoacetic acid esters | |
| GB1230840A (enrdf_load_stackoverflow) | ||
| ES428004A1 (es) | Procedimiento para la preparacion de derivados de bifenilo. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |