GB1457069A - Process for the prepataion of n-formyl diindole alkaloids - Google Patents

Process for the prepataion of n-formyl diindole alkaloids

Info

Publication number
GB1457069A
GB1457069A GB5496474A GB5496474A GB1457069A GB 1457069 A GB1457069 A GB 1457069A GB 5496474 A GB5496474 A GB 5496474A GB 5496474 A GB5496474 A GB 5496474A GB 1457069 A GB1457069 A GB 1457069A
Authority
GB
United Kingdom
Prior art keywords
formyl
diindole
alkaloids
dec
leurosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5496474A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB1457069A publication Critical patent/GB1457069A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1457069 Preparation of N-formyl diindole alkaloids RICHTER GEDEON VEGYESZETI GYAR RT 19 Dec 1974 [20 Dec 1973] 54964/74 Heading C2C The invention comprises a process for preparing N-formyl diindole alkaloids wherein the formyl group is attached to an indole nitrogen atom by oxidizing the corresponding diindole alkaloid having a methyl group attached to an indole nitrogen atom using oxygen in formic acid in the presence of a catalyst comprising a metal of Group VIII of the Periodic Table. The process may be effected in the presence of an aromatic solvent such as benzene. Examples of the catalyst are platinum black, platinum sponge and palladium. The process is exemplified by oxidation of vinblastine to vincristine and leurosine to N- formyl leurosine.
GB5496474A 1973-12-20 1974-12-19 Process for the prepataion of n-formyl diindole alkaloids Expired GB1457069A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI531A HU168433B (en) 1973-12-20 1973-12-20

Publications (1)

Publication Number Publication Date
GB1457069A true GB1457069A (en) 1976-12-01

Family

ID=11000942

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5496474A Expired GB1457069A (en) 1973-12-20 1974-12-19 Process for the prepataion of n-formyl diindole alkaloids

Country Status (8)

Country Link
JP (1) JPS5095300A (en)
AT (1) AT335077B (en)
BE (1) BE823560A (en)
DD (1) DD116042A5 (en)
GB (1) GB1457069A (en)
HU (1) HU168433B (en)
IL (1) IL46286A0 (en)
RO (1) RO63736A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0037290B1 (en) * 1980-04-02 1984-03-21 Eli Lilly And Company Process for preparing a vinca dimer
EP0037289B1 (en) * 1980-04-02 1984-08-01 Eli Lilly And Company Method of preparing a vinca dimer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0037290B1 (en) * 1980-04-02 1984-03-21 Eli Lilly And Company Process for preparing a vinca dimer
EP0037289B1 (en) * 1980-04-02 1984-08-01 Eli Lilly And Company Method of preparing a vinca dimer

Also Published As

Publication number Publication date
HU168433B (en) 1976-04-28
IL46286A0 (en) 1975-03-13
BE823560A (en) 1975-04-16
RO63736A (en) 1978-10-15
DD116042A5 (en) 1975-11-05
ATA1005074A (en) 1976-06-15
JPS5095300A (en) 1975-07-29
AT335077B (en) 1977-02-25

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee