GB1454585A - N-heteroarylmethyl-2-hydroxy-5,9,9-trimethyl-benzomorphans - Google Patents

N-heteroarylmethyl-2-hydroxy-5,9,9-trimethyl-benzomorphans

Info

Publication number
GB1454585A
GB1454585A GB1366974A GB1366974A GB1454585A GB 1454585 A GB1454585 A GB 1454585A GB 1366974 A GB1366974 A GB 1366974A GB 1366974 A GB1366974 A GB 1366974A GB 1454585 A GB1454585 A GB 1454585A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
benzomorphans
heteroarylmethyl
trimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1366974A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of GB1454585A publication Critical patent/GB1454585A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

1454585 N - (Heteroarylmethyl) - 2<SP>1 </SP>- hydroxy - 5,9,9 - trimethyl - benzomorphans BOEHRINGER INGELHEIM GmbH 27 March 1974 [28 March 1973] 13669/74 Heading C2C Novel compounds of the Formula I wherein R is hydrogen or methyl and X is oxygen or sulphur and acid addition salts thereof may be prepared by (a) condensing compounds of the Formulµ II with compounds III wherein Y is an atom or group removable as an anion or (b) reducing a compound of the Formula IV The intermediates of the Formula IV may be prepared by reacting a compound of the Formula II with a corresponding thiophene or furan carboxylic acid. Pharmaceutical compositions of one or more of the compounds I with the usual excipients when administered orally, parenterally or rectally show morphine antagonistic and/or analgesic activity. Another analgesic or a sedative, tranquilizer or hypnotic may be added.
GB1366974A 1973-03-28 1974-03-27 N-heteroarylmethyl-2-hydroxy-5,9,9-trimethyl-benzomorphans Expired GB1454585A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2315339A DE2315339A1 (en) 1973-03-28 1973-03-28 N- (HETEROARYLMETHYL) -2'-HYDROXY-5.9. 9-TRIMETHYL BENZOMORPHANES, THEIR ACID ADDITION SALTS, THE MEDICINAL PRODUCTS CONTAINING THESE AND THE METHOD FOR THEIR MANUFACTURING

Publications (1)

Publication Number Publication Date
GB1454585A true GB1454585A (en) 1976-11-03

Family

ID=5876125

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1366974A Expired GB1454585A (en) 1973-03-28 1974-03-27 N-heteroarylmethyl-2-hydroxy-5,9,9-trimethyl-benzomorphans

Country Status (6)

Country Link
DE (1) DE2315339A1 (en)
DK (1) DK137386C (en)
FI (1) FI62078C (en)
GB (1) GB1454585A (en)
NO (1) NO137389C (en)
SE (1) SE411209B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (en) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts.

Also Published As

Publication number Publication date
NO137389B (en) 1977-11-14
FI62078B (en) 1982-07-30
NO741098L (en) 1974-10-01
FI62078C (en) 1982-11-10
DK137386C (en) 1978-08-07
NO137389C (en) 1978-02-22
DK137386B (en) 1978-02-27
SE411209B (en) 1979-12-10
DE2315339A1 (en) 1974-10-17

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee