GB1451843A - Spirolactone steroids processes for their preparation and proces ses for converting them into related compounds - Google Patents
Spirolactone steroids processes for their preparation and proces ses for converting them into related compoundsInfo
- Publication number
- GB1451843A GB1451843A GB545174A GB545174A GB1451843A GB 1451843 A GB1451843 A GB 1451843A GB 545174 A GB545174 A GB 545174A GB 545174 A GB545174 A GB 545174A GB 1451843 A GB1451843 A GB 1451843A
- Authority
- GB
- United Kingdom
- Prior art keywords
- preparation
- spirolactone
- steroids
- converting
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 2
- 230000008569 process Effects 0.000 title 2
- -1 Spirolactone steroids Chemical class 0.000 title 1
- 229960002256 spironolactone Drugs 0.000 title 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000686 lactone group Chemical group 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7304057A FR2216273B1 (cg-RX-API-DMAC10.html) | 1973-02-06 | 1973-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1451843A true GB1451843A (en) | 1976-10-06 |
Family
ID=9114388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB545174A Expired GB1451843A (en) | 1973-02-06 | 1974-02-06 | Spirolactone steroids processes for their preparation and proces ses for converting them into related compounds |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3897417A (cg-RX-API-DMAC10.html) |
| JP (1) | JPS5829320B2 (cg-RX-API-DMAC10.html) |
| AT (1) | AT336811B (cg-RX-API-DMAC10.html) |
| BE (1) | BE810643A (cg-RX-API-DMAC10.html) |
| CA (1) | CA1026318A (cg-RX-API-DMAC10.html) |
| CH (2) | CH609710A5 (cg-RX-API-DMAC10.html) |
| DK (1) | DK134818B (cg-RX-API-DMAC10.html) |
| ES (2) | ES422921A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2216273B1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB1451843A (cg-RX-API-DMAC10.html) |
| IE (1) | IE39329B1 (cg-RX-API-DMAC10.html) |
| LU (1) | LU69328A1 (cg-RX-API-DMAC10.html) |
| NL (1) | NL179288C (cg-RX-API-DMAC10.html) |
| SE (2) | SE399270B (cg-RX-API-DMAC10.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4058522A (en) * | 1973-07-09 | 1977-11-15 | Richter Gedeon Vegyeszeti Gyar Rt. | Steroids effective against heavy-metal poisoning |
| IT1130924B (it) * | 1980-03-06 | 1986-06-18 | Secifarma Spa | Procedimento per la preparazione di spironolattone micronizzato |
| US4501695A (en) * | 1983-05-16 | 1985-02-26 | The Upjohn Company | Spironalactone process |
| WO1997021720A2 (en) | 1995-12-11 | 1997-06-19 | G.D. Searle And Co. | Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds |
| NZ336004A (en) | 1996-12-11 | 2001-04-27 | G | Process for preparation of 3-keto-7-alpha-alkoxycarbonyl substituted delta-4,5-steroid by reacting 4,5-dihydro-5,7-lactone steroid substrate in the presence of a base |
| US6887991B1 (en) * | 1996-12-11 | 2005-05-03 | G. D. Searle & Company | Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein |
| RU2163606C1 (ru) * | 1999-12-08 | 2001-02-27 | Андрюшина Валентина Александровна | СПОСОБ ПОЛУЧЕНИЯ γ-ЛАКТОНА 3(7α-АЦЕТИЛТИО-17β-ГИДРОКСИ-3-ОКСОАНДРОСТ-4-ЕН-17α-ИЛ)ПРОПИОНОВОЙ КИСЛОТЫ |
| EP1487859B1 (en) * | 2002-03-22 | 2008-08-13 | Pharmacia & Upjohn Company LLC | Process to prepare eplerenone |
| US7235655B2 (en) * | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
| DE102005049393B4 (de) * | 2005-10-15 | 2019-08-08 | Kennametal Widia Produktions Gmbh & Co. Kg | Verfahren zur Herstellung eines beschichteten Substratkörpers, Substratkörper mit einer Beschichtung und Verwendung des beschichteten Substratkörpers |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1329570A (fr) * | 1959-12-10 | 1963-06-14 | Searle & Co | Procédé de préparation des lactones d'alcanoylthio-17alpha-carboxyéthyl-17bêta-hydroxy-3-oxoandrostènes |
| US3257390A (en) * | 1963-06-12 | 1966-06-21 | Merck & Co Inc | Ring a unsaturated 21-hydroxy-3-oxo-17alpha-pregnane-17-carboxylic acid lactone diuretic agents |
| US3300489A (en) * | 1964-07-24 | 1967-01-24 | Smith Kline French Lab | Steroidal c-17 spirolactones and processes and intermediates used in the preparation thereof |
-
1973
- 1973-02-06 FR FR7304057A patent/FR2216273B1/fr not_active Expired
-
1974
- 1974-02-01 US US438601A patent/US3897417A/en not_active Expired - Lifetime
- 1974-02-05 LU LU69328A patent/LU69328A1/xx unknown
- 1974-02-05 BE BE140580A patent/BE810643A/xx unknown
- 1974-02-05 ES ES422921A patent/ES422921A1/es not_active Expired
- 1974-02-05 CH CH385975A patent/CH609710A5/xx not_active IP Right Cessation
- 1974-02-05 CH CH158474A patent/CH595399A5/xx not_active IP Right Cessation
- 1974-02-05 SE SE7401494A patent/SE399270B/xx not_active IP Right Cessation
- 1974-02-05 CA CA191,844A patent/CA1026318A/en not_active Expired
- 1974-02-06 NL NLAANVRAGE7401656,A patent/NL179288C/xx not_active IP Right Cessation
- 1974-02-06 JP JP49014627A patent/JPS5829320B2/ja not_active Expired
- 1974-02-06 DK DK62574AA patent/DK134818B/da not_active IP Right Cessation
- 1974-02-06 AT AT92174A patent/AT336811B/de not_active IP Right Cessation
- 1974-02-06 GB GB545174A patent/GB1451843A/en not_active Expired
- 1974-02-06 IE IE226/74A patent/IE39329B1/xx unknown
-
1976
- 1976-01-07 ES ES444112A patent/ES444112A1/es not_active Expired
-
1977
- 1977-06-03 SE SE7706509A patent/SE440782B/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2216273B1 (cg-RX-API-DMAC10.html) | 1977-07-22 |
| CH595399A5 (cg-RX-API-DMAC10.html) | 1978-02-15 |
| NL179288C (nl) | 1986-08-18 |
| IE39329L (en) | 1974-08-06 |
| BE810643A (fr) | 1974-08-05 |
| SE7706509L (sv) | 1977-06-03 |
| DK134818C (cg-RX-API-DMAC10.html) | 1977-06-13 |
| ATA92174A (de) | 1976-09-15 |
| ES444112A1 (es) | 1977-08-16 |
| SE440782B (sv) | 1985-08-19 |
| FR2216273A1 (cg-RX-API-DMAC10.html) | 1974-08-30 |
| US3897417A (en) | 1975-07-29 |
| IE39329B1 (en) | 1978-09-13 |
| JPS49109365A (cg-RX-API-DMAC10.html) | 1974-10-17 |
| ES422921A1 (es) | 1976-09-16 |
| AT336811B (de) | 1977-05-25 |
| CH609710A5 (cg-RX-API-DMAC10.html) | 1979-03-15 |
| DK134818B (da) | 1977-01-24 |
| SE399270B (sv) | 1978-02-06 |
| NL7401656A (cg-RX-API-DMAC10.html) | 1974-08-08 |
| NL179288B (nl) | 1986-03-17 |
| AU6521174A (en) | 1975-08-07 |
| CA1026318A (en) | 1978-02-14 |
| LU69328A1 (cg-RX-API-DMAC10.html) | 1974-09-25 |
| JPS5829320B2 (ja) | 1983-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |