GB1442474A - Process for the production of beta-2-p-chlorophenoxy-isobutyryloxy -ethyl nicotinate - Google Patents

Process for the production of beta-2-p-chlorophenoxy-isobutyryloxy -ethyl nicotinate

Info

Publication number
GB1442474A
GB1442474A GB3877874A GB3877874A GB1442474A GB 1442474 A GB1442474 A GB 1442474A GB 3877874 A GB3877874 A GB 3877874A GB 3877874 A GB3877874 A GB 3877874A GB 1442474 A GB1442474 A GB 1442474A
Authority
GB
United Kingdom
Prior art keywords
isobutyryloxy
chlorophenoxy
beta
production
ethyl nicotinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3877874A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz and Co GmbH and Co KG
Original Assignee
Merz and Co GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz and Co GmbH and Co KG filed Critical Merz and Co GmbH and Co KG
Priority to GB3877874A priority Critical patent/GB1442474A/en
Priority to AR260267A priority patent/AR205658A1/en
Priority to DE19752531254 priority patent/DE2531254A1/en
Priority to FI752079A priority patent/FI60392C/en
Priority to YU1923/75A priority patent/YU37132B/en
Priority to AT591475A priority patent/AT344173B/en
Priority to NO752762A priority patent/NO752762L/no
Priority to BE159356A priority patent/BE832618R/en
Priority to CA234,142A priority patent/CA1054153A/en
Priority to DK390875A priority patent/DK145929C/en
Priority to JP50105573A priority patent/JPS597702B2/en
Priority to HUME1893A priority patent/HU169891B/hu
Priority to ES440711A priority patent/ES440711A1/en
Priority to FR7527367A priority patent/FR2283892A2/en
Priority to NL7510526A priority patent/NL7510526A/en
Priority to PL1975183136A priority patent/PL97697B1/en
Priority to CH1151575A priority patent/CH584198A5/xx
Publication of GB1442474A publication Critical patent/GB1442474A/en
Priority to US05/750,594 priority patent/US4051143A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1442474 # - [2 - (p - Chlorophenoxy)isobutyryloxy] - ethyl nicotinate MERZ & CO 5 Sept 1974 38778/74 Heading C2C [Also in Division A5] # - [2 - (p - Chlorophenoxy) - isobutyryloxy]- ethyl nicotinate is prepared by reacting #-[2-(pchlorophenoxy) - isobutyryloxy] - ethyl chloride with an alkali metal nicotinate. # - [2 - (p - Chlorophenoxy) - isobutyryloxy]- ethyl chloride is prepared by reacting 2-(pchlorophenoxy)isobutyric acid with #-chloroethanol in the presence of boron trifluoride.
GB3877874A 1974-09-05 1974-09-05 Process for the production of beta-2-p-chlorophenoxy-isobutyryloxy -ethyl nicotinate Expired GB1442474A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GB3877874A GB1442474A (en) 1974-09-05 1974-09-05 Process for the production of beta-2-p-chlorophenoxy-isobutyryloxy -ethyl nicotinate
AR260267A AR205658A1 (en) 1974-09-05 1975-01-01 PROCEDURE FOR THE PREPARATION OF ESTER ALPHA- (2- (P-CHLOROPHENOXY) -ISOBUTYRIL) -BETA-NICOTINOYL GLYCOLIC
DE19752531254 DE2531254A1 (en) 1974-09-05 1975-07-12 IMPROVED PROCESS FOR MANUFACTURING ALPHA-SQUARE CLIP ON 2- (P-CHLOROPHENOXY) -ISOBUTYRYL SQUARE CLIP FOR BETA-NICOTINOYL GLYCOLESTER
FI752079A FI60392C (en) 1974-09-05 1975-07-18 FOERFARANDE FOER FRAMSTAELLNING AV BETA- (2- (P-CHLOROPHENOXY) -ISOBUTYRYLOXY) -EHYLNICOTINAT
YU1923/75A YU37132B (en) 1974-09-05 1975-07-28 Process for obtainig 2-(p-chlorophenoxy)-isobutyryl)-nicotinoyl glycolesters
AT591475A AT344173B (en) 1974-09-05 1975-07-30 PROCESS FOR PREPARING ALFA- (2- (P-CHLOROPHENOXY) -ISOBUTYRYL) -BETA-NICOTINOYL GLYCOLESTER
NO752762A NO752762L (en) 1974-09-05 1975-08-06
BE159356A BE832618R (en) 1974-09-05 1975-08-21 ALPHA-HALOGENOPHENOXY-ISOBUTYROYL-BETA-NICOTINOYLGLYCOLS AND THEIR PREPARATION PROCESS
CA234,142A CA1054153A (en) 1974-09-05 1975-08-25 PROCESS FOR THE PRODUCTION OF .alpha.(-2-(P-CHLOROPHENOXY)-ISOBUTYRYL)-.beta.-NICOTINOYL GLYCOL ESTER
DK390875A DK145929C (en) 1974-09-05 1975-08-29 METHOD FOR PREPARING BETA- (2- (P-CHLORPHENOXY) -ISOBUTYRYLOXY) -ETHYLNICOTINATE
JP50105573A JPS597702B2 (en) 1974-09-05 1975-08-30 alpha-(2-(P-chlorophenoxy)-isobutyl)-beta-nicotinoyl glycol ester
HUME1893A HU169891B (en) 1974-09-05 1975-09-04
ES440711A ES440711A1 (en) 1974-09-05 1975-09-04 Process for the production of beta-2-p-chlorophenoxy-isobutyryloxy -ethyl nicotinate
FR7527367A FR2283892A2 (en) 1974-09-05 1975-09-05 A- (2- (P-CHLOROPHENOXY) -ISOBUTYRYL) -B-NICOTINOYL GLYCOLIC ESTER MANUFACTURING PROCESS
NL7510526A NL7510526A (en) 1974-09-05 1975-09-05 METHOD OF PREPARATION FOR (ALPHA) - (2- (P-CHLOROPHENOXY) - -ISOBUTYRYL) - (BETA) -NICOTINOYL GLYCOLESTER.
PL1975183136A PL97697B1 (en) 1974-09-05 1975-09-05 METHOD OF MAKING ALPHA - (2- / P-CHLOROPHENOXY / - ISOMBUTATE) -BETA- / NICOTATE / -ETHYLENE GLYCOL
CH1151575A CH584198A5 (en) 1974-09-05 1975-09-05
US05/750,594 US4051143A (en) 1974-09-05 1976-12-15 Process for the production of α-[2-(p-chlorophenoxy)-isobutyryl]-β-nicotinoyl glycol ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3877874A GB1442474A (en) 1974-09-05 1974-09-05 Process for the production of beta-2-p-chlorophenoxy-isobutyryloxy -ethyl nicotinate

Publications (1)

Publication Number Publication Date
GB1442474A true GB1442474A (en) 1976-07-14

Family

ID=10405641

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3877874A Expired GB1442474A (en) 1974-09-05 1974-09-05 Process for the production of beta-2-p-chlorophenoxy-isobutyryloxy -ethyl nicotinate

Country Status (17)

Country Link
JP (1) JPS597702B2 (en)
AR (1) AR205658A1 (en)
AT (1) AT344173B (en)
BE (1) BE832618R (en)
CA (1) CA1054153A (en)
CH (1) CH584198A5 (en)
DE (1) DE2531254A1 (en)
DK (1) DK145929C (en)
ES (1) ES440711A1 (en)
FI (1) FI60392C (en)
FR (1) FR2283892A2 (en)
GB (1) GB1442474A (en)
HU (1) HU169891B (en)
NL (1) NL7510526A (en)
NO (1) NO752762L (en)
PL (1) PL97697B1 (en)
YU (1) YU37132B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375545A (en) * 1981-06-22 1983-03-01 Westwood Pharmaceuticals, Inc. Process for the synthesis of the nicotinyl ester of 6-aminonicotinic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2304405A1 (en) * 1972-03-08 1973-09-13 Hurka Wilhelm 4-chlorophenoxy-isobutyric acid esters - with antiarteriosclerotic activity

Also Published As

Publication number Publication date
JPS597702B2 (en) 1984-02-20
FR2283892A2 (en) 1976-04-02
JPS5168572A (en) 1976-06-14
DK145929B (en) 1983-04-18
FI60392B (en) 1981-09-30
FR2283892B2 (en) 1980-08-08
CH584198A5 (en) 1977-01-31
FI60392C (en) 1982-01-11
CA1054153A (en) 1979-05-08
YU192375A (en) 1983-04-27
ATA591475A (en) 1977-11-15
NL7510526A (en) 1976-03-09
BE832618R (en) 1975-12-16
DE2531254A1 (en) 1976-03-25
YU37132B (en) 1984-08-31
AT344173B (en) 1978-07-10
NO752762L (en) 1976-03-08
DK390875A (en) 1976-03-06
ES440711A1 (en) 1977-03-16
FI752079A (en) 1976-03-06
HU169891B (en) 1977-02-28
PL97697B1 (en) 1978-03-30
AR205658A1 (en) 1976-05-21
DK145929C (en) 1983-09-26

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930905