GB1440275A - Injectable solutions containing aminoketone derivatives and process for the preparation thereof - Google Patents

Injectable solutions containing aminoketone derivatives and process for the preparation thereof

Info

Publication number
GB1440275A
GB1440275A GB5932473A GB5932473A GB1440275A GB 1440275 A GB1440275 A GB 1440275A GB 5932473 A GB5932473 A GB 5932473A GB 5932473 A GB5932473 A GB 5932473A GB 1440275 A GB1440275 A GB 1440275A
Authority
GB
United Kingdom
Prior art keywords
hydrochloride
piperidino
oxide adduct
propan
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5932473A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB1440275A publication Critical patent/GB1440275A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1440275 Respiratory stimulating composition RICHTER GEDEON VEGYESZETI GYAR RT 21 Dec 1973 [15 Jan 1973] 59324/ 73 Heading A5B A stable injectable solution comprises (i) an aminoketone derivative of formula: wherein R1 is hydrogen or C1-4 alkyl and R2 is alkylphenyl wherein the alkyl group contains 1 to 10 carbon atoms or R1 and R2 together represent a C3-5 alkylene group and X represents an anion or one equivalent of a polyvalent anion, (ii) a nonionic surface active agent, (iii) a polyhydric alcohol, (iv) an ammonium or amine salt of a strong acid and (v) an organic acid having a pKa value between 2 and 4. In the formula X may be chloride or sulphate. Compounds specified include (i) 1- piperidino - 3 - (4' - n - octylphenyl) - propan- 3-one hydrochloride, 1-piperidino-2-methyl-3- (4-methylphenyl)-propan-3-one hydrochloride and 1-piperidino-methyl-cyclohexane-2-one hydrochloride (ii) an oleic ester-alkylene oxide adduct, a castor oil-ethylene oxide adduct, sorbitan monolaurate-ethylene oxide adduct, (iii) propyleneglycol, glycerol, polyethylene glycol, (iv) ammonium chloride, piperidine hydrochloride, (v) ascorbic acid, maleic acid. The composition may also include a local anaesthetic, e.g. lindocaine hydrochloride.
GB5932473A 1973-01-15 1973-12-21 Injectable solutions containing aminoketone derivatives and process for the preparation thereof Expired GB1440275A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI496A HU166289B (en) 1973-01-15 1973-01-15

Publications (1)

Publication Number Publication Date
GB1440275A true GB1440275A (en) 1976-06-23

Family

ID=11000913

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5932473A Expired GB1440275A (en) 1973-01-15 1973-12-21 Injectable solutions containing aminoketone derivatives and process for the preparation thereof

Country Status (13)

Country Link
JP (1) JPS505521A (en)
AT (1) AT332552B (en)
AU (1) AU6354673A (en)
BE (1) BE809693A (en)
CS (1) CS172273B2 (en)
DD (1) DD108460A5 (en)
DE (1) DE2362337A1 (en)
DK (1) DK134742B (en)
FR (1) FR2213768B1 (en)
GB (1) GB1440275A (en)
HU (1) HU166289B (en)
IL (1) IL43814A0 (en)
NL (1) NL7317458A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54125630A (en) * 1978-02-22 1979-09-29 Nippon Zoki Pharmaceutical Co Novel propanone derivative*its manufacture and medical composition containing it as active component

Also Published As

Publication number Publication date
FR2213768B1 (en) 1977-07-01
NL7317458A (en) 1974-07-17
ATA22374A (en) 1976-01-15
FR2213768A1 (en) 1974-08-09
DD108460A5 (en) 1974-09-20
DK134742B (en) 1977-01-10
AT332552B (en) 1976-10-11
BE809693A (en) 1974-05-02
JPS505521A (en) 1975-01-21
DE2362337A1 (en) 1974-07-18
HU166289B (en) 1975-02-28
IL43814A0 (en) 1974-03-14
CS172273B2 (en) 1976-12-29
AU6354673A (en) 1975-06-12

Similar Documents

Publication Publication Date Title
ES8506677A1 (en) Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions.
HUP9903766A2 (en) Pyridyl alkene- and pyridyl alkine- acid amides, use of them as cytostatics and immunosuppressives, process for their preparation and pharmaceuticals containing the same
GB1026778A (en) 2-benzyl-2-imidazoline compounds and compositions including them
GB1527297A (en) Pyrazine carboxamides
HUT43051A (en) Process for preparing pyridine-carboxylic acid derivatives and pharmaceutical compositions containing thereof as active ingredients
GR3002832T3 (en) Flavone carboxylic acid derivatives
ES8501362A1 (en) Phthalazine substituted aminomethyl benzene derivatives, compositions and use.
ES8500948A1 (en) Morphinane derivatives, their preparation and pharmaceutical preparations containing them.
KR830009771A (en) Process for preparing a formulation containing TRM or an analog thereof
ES482472A1 (en) Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them.
ES8800142A1 (en) Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same.
GB1440275A (en) Injectable solutions containing aminoketone derivatives and process for the preparation thereof
ES8308889A1 (en) Novel mono - and bisquaternary ammonium derivatives of 2-beta, 16-beta-diamino-5-alpha-androstane derivatives and pharmaceutical preparations containing same.
DK530685A (en) 9-CHLOR-1,5-BENZOTHIAZEPINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
GB1421006A (en) Imidazolidine derivatives
US4344950A (en) Parenteral solvent and a process for the preparation of stable solutions containing same
KR850000455A (en) Method for preparing cephalosporin ester derivative
GB1492029A (en) 4-oxo-1,4-dihydro-1,6-benzo-(h)-naphthyridine-3-carboxylic acid derivatives useful as anti-bacterial agents and their preparation
KR920000759A (en) Novel drugs containing 3,7-diazabicyclo [3,3,1] nonane compounds
GB1512101A (en) Piperazinopyrimidines process for their preparation and use
GB1178946A (en) Bis-Triiodoisophthalamic Acid Compounds
ES363591A1 (en) beta-PHENETHYLAMINE DERIVATIVES AND A PROCESS FOR THE MANUFACTURE THEREOF
ES8801652A1 (en) Thiazolidine derivatives and process for preparing the same.
KR840008012A (en) Method for preparing aminoethyl-pyridine and -pyrazine derivatives
GB1163921A (en) Azadibenzocycloheptene Derivatives

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee