GB1438612A - Glycyrrhetinic acid derivatives - Google Patents
Glycyrrhetinic acid derivativesInfo
- Publication number
- GB1438612A GB1438612A GB581774A GB581774A GB1438612A GB 1438612 A GB1438612 A GB 1438612A GB 581774 A GB581774 A GB 581774A GB 581774 A GB581774 A GB 581774A GB 1438612 A GB1438612 A GB 1438612A
- Authority
- GB
- United Kingdom
- Prior art keywords
- glycyrrhetinic
- glycyrrhetinic acid
- metoclopramide
- reaction
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical class C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 abstract 3
- MPDGHEJMBKOTSU-WFJWTYAKSA-N (2s,4as,6as,6br,10s,12as)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid Chemical compound C12C(=O)C=C3C4C[C@@](C)(C(O)=O)CC[C@]4(C)CC[C@@]3(C)[C@]1(C)CCC1[C@]2(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-WFJWTYAKSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229960004503 metoclopramide Drugs 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- NWJZWHGSBTVTGM-UHFFFAOYSA-N 1-[bis(aziridin-1-yl)phosphoryl]-3-phenylurea Chemical compound C1CN1P(=O)(N1CC1)NC(=O)NC1=CC=CC=C1 NWJZWHGSBTVTGM-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 abstract 1
- 229960003720 enoxolone Drugs 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229940070765 laurate Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002763 monocarboxylic acids Chemical class 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB581774A GB1438612A (en) | 1974-02-08 | 1974-02-08 | Glycyrrhetinic acid derivatives |
| DE19752504569 DE2504569A1 (de) | 1974-02-08 | 1975-02-04 | Glycyrrethinsaeurederivate, verfahren zu ihrer herstellung und mittel, worin diese enthalten sind |
| JP50016138A JPS50112353A (en, 2012) | 1974-02-08 | 1975-02-06 | |
| FR7503763A FR2260338B1 (en, 2012) | 1974-02-08 | 1975-02-06 | |
| US05/548,767 US4002655A (en) | 1974-02-08 | 1975-02-10 | Glycyrrhetinic acid derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB581774A GB1438612A (en) | 1974-02-08 | 1974-02-08 | Glycyrrhetinic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1438612A true GB1438612A (en) | 1976-06-09 |
Family
ID=9803163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB581774A Expired GB1438612A (en) | 1974-02-08 | 1974-02-08 | Glycyrrhetinic acid derivatives |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4002655A (en, 2012) |
| JP (1) | JPS50112353A (en, 2012) |
| DE (1) | DE2504569A1 (en, 2012) |
| FR (1) | FR2260338B1 (en, 2012) |
| GB (1) | GB1438612A (en, 2012) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2623228C3 (de) * | 1976-05-24 | 1981-09-10 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | N-Acyl-substituierte Benzamide, Verfahren zu ihrer Herstellung und Arzneimittel, enthaltend solche Benzamide |
| GB8921792D0 (en) * | 1989-09-27 | 1989-11-08 | May & Baker Ltd | New compositions of matter |
| JPH0533391A (ja) * | 1991-03-22 | 1993-02-09 | Kajima Corp | 柱・梁接合部構造 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1060344A (en) * | 1965-02-11 | 1967-03-01 | Biorex Laboratories Ltd | New derivatives of glycyrrhetinic and oleanolic acids |
| US3734944A (en) * | 1970-05-15 | 1973-05-22 | Biorex Laboratories Ltd | Glycyrrhetinic acid esters |
| US3810927A (en) * | 1972-02-10 | 1974-05-14 | Searle & Co | 3-oxygenated-30-methylolean-12-en-30-ones and 11-oxo derivatives thereof |
-
1974
- 1974-02-08 GB GB581774A patent/GB1438612A/en not_active Expired
-
1975
- 1975-02-04 DE DE19752504569 patent/DE2504569A1/de not_active Withdrawn
- 1975-02-06 JP JP50016138A patent/JPS50112353A/ja active Pending
- 1975-02-06 FR FR7503763A patent/FR2260338B1/fr not_active Expired
- 1975-02-10 US US05/548,767 patent/US4002655A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2260338B1 (en, 2012) | 1980-01-11 |
| JPS50112353A (en, 2012) | 1975-09-03 |
| FR2260338A1 (en, 2012) | 1975-09-05 |
| DE2504569A1 (de) | 1975-08-14 |
| US4002655A (en) | 1977-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |