GB1428539A - Substituted adenosine cyclophosphates - Google Patents
Substituted adenosine cyclophosphatesInfo
- Publication number
- GB1428539A GB1428539A GB3511073A GB3511073A GB1428539A GB 1428539 A GB1428539 A GB 1428539A GB 3511073 A GB3511073 A GB 3511073A GB 3511073 A GB3511073 A GB 3511073A GB 1428539 A GB1428539 A GB 1428539A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- dinitrophenyl
- reacting
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1428539 Purine nucleotides MAX-PLANCKGES ZUR FORDERUNG DER WISSENSCHAFTEN eV 24 July 1973 [25 July 1972] 35110/73 Headings C2P and C2C The invention comprises compounds of formula where X is hydrogen and R is 2,4-dinitrophenyl or where X is Cl or Br and R is H and the salts thereof with physiologically compatible acids and bases. Compounds of Formula I in which X is chlorine or bromine may be prepared by phosphorylating 2-chloro- or 2-bromoadenosine with phosphorus oxychloride and cyclizing the reaction product, which may be isolated with dicyclohexylcarbodiimide in a strongly polar organic solvent. Compounds of Formula I in which R is dinitrophenyl may be prepared by reacting adenosine-3,5<SP>1</SP>-cyclophosphate with 2,4-dinitrofluorobenzene in the presence of diisopropylethylamine in a polar organic solvent. The starting materials 2-chloro- and 2-bromoadenosine may be prepared by reacting 2,6- dichloro- or 2,6-dibromopurine with beta-D- ribofuranose 1,2,3,5-tetraacetate in the presence of toluene sulphonic acid to give 9-(tri-O-acetylbeta - D - ribofuranosyl) - 2,6 - dichloro- or -2,6-dibromopurine and reacting this product, dissolved in anhydrous methanol, with ammonia. Compounds of Formula I in which R is 2,4- dinitrophenyl may be reduced to give a corresponding compound in which R is 2,4-diaminophenyl. Compounds of Formula I in which X is halogen may be used to prepare adenosine-3<SP>1</SP>,5<SP>1</SP>- cyclophosphate derivatives substituted in the 2-position by methoxy, methylthio, dimethylamino, methylamino, hydrazino or azido. The compounds of Formula I have pharmaceutical properties and may be used as the active ingredients in conventional pharmaceutical compositions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19722236442 DE2236442A1 (en) | 1972-07-25 | 1972-07-25 | NEW SUBSTITUTED ADENOSINE CYCLOPHOSPHATE |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1428539A true GB1428539A (en) | 1976-03-17 |
Family
ID=5851622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3511073A Expired GB1428539A (en) | 1972-07-25 | 1973-07-24 | Substituted adenosine cyclophosphates |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS49116096A (en) |
AT (1) | AT329191B (en) |
DE (1) | DE2236442A1 (en) |
FR (1) | FR2193615B1 (en) |
GB (1) | GB1428539A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101781348A (en) * | 2010-01-18 | 2010-07-21 | 刘力 | Stable protein kinase activator, preparation method thereof and use |
CN102796156B (en) * | 2012-08-24 | 2014-07-30 | 宁辉 | Adenosine cyclophosphate double-molecule meglumine compound and preparation method thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3249M (en) * | 1963-03-30 | 1965-04-12 | Takeda Chemical Industries Ltd | Vasodilator preparation. |
DE1922172C3 (en) * | 1969-04-30 | 1980-12-18 | Boehringer Mannheim Gmbh, 6800 Mannheim | S'-cyclophosphate |
-
1972
- 1972-07-25 DE DE19722236442 patent/DE2236442A1/en active Pending
-
1973
- 1973-07-03 AT AT587673A patent/AT329191B/en not_active IP Right Cessation
- 1973-07-24 GB GB3511073A patent/GB1428539A/en not_active Expired
- 1973-07-25 FR FR7327235A patent/FR2193615B1/fr not_active Expired
- 1973-07-25 JP JP8394073A patent/JPS49116096A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATA587673A (en) | 1975-07-15 |
FR2193615B1 (en) | 1977-02-25 |
AT329191B (en) | 1976-04-26 |
FR2193615A1 (en) | 1974-02-22 |
DE2236442A1 (en) | 1974-02-14 |
JPS49116096A (en) | 1974-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |