GB1426557A - Production of substituted monomalonate esters and their use in the production of alpha-carboxy penicillins and cephalosporins - Google Patents
Production of substituted monomalonate esters and their use in the production of alpha-carboxy penicillins and cephalosporinsInfo
- Publication number
- GB1426557A GB1426557A GB4593672A GB4593672A GB1426557A GB 1426557 A GB1426557 A GB 1426557A GB 4593672 A GB4593672 A GB 4593672A GB 4593672 A GB4593672 A GB 4593672A GB 1426557 A GB1426557 A GB 1426557A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ester
- substituted
- production
- carboxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 3
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title 1
- -1 acetate ester Chemical class 0.000 abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052744 lithium Inorganic materials 0.000 abstract 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- 150000001263 acyl chlorides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4593672A GB1426557A (en) | 1972-10-05 | 1972-10-05 | Production of substituted monomalonate esters and their use in the production of alpha-carboxy penicillins and cephalosporins |
| BE136034A BE805298A (fr) | 1972-10-05 | 1973-09-25 | Procede de preparation de mono-malonates |
| DE19732348473 DE2348473A1 (de) | 1972-10-05 | 1973-09-26 | Verfahren zur herstellung von substituierten malonsaeure-monoestern und ihre verwendung zur herstellung von alphacarboxypenicillinen oder cephalosporinen |
| FR7334471A FR2202093B1 (enrdf_load_stackoverflow) | 1972-10-05 | 1973-09-26 | |
| SE7313478A SE402774B (sv) | 1972-10-05 | 1973-10-03 | Forfarande for framstellning av monoestrar av 2-heterocykelsubstituerade malonsyror |
| CH1418173A CH587275A5 (enrdf_load_stackoverflow) | 1972-10-05 | 1973-10-04 | |
| NL7313636A NL7313636A (enrdf_load_stackoverflow) | 1972-10-05 | 1973-10-04 | |
| DK540573A DK132409C (da) | 1972-10-05 | 1973-10-04 | Fremgangsmade til fremstilling af heterocyclisk substitueredemalonatestere |
| JP11109173A JPS5745226B2 (enrdf_load_stackoverflow) | 1972-10-05 | 1973-10-04 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4593672A GB1426557A (en) | 1972-10-05 | 1972-10-05 | Production of substituted monomalonate esters and their use in the production of alpha-carboxy penicillins and cephalosporins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1426557A true GB1426557A (en) | 1976-03-03 |
Family
ID=10439170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4593672A Expired GB1426557A (en) | 1972-10-05 | 1972-10-05 | Production of substituted monomalonate esters and their use in the production of alpha-carboxy penicillins and cephalosporins |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5745226B2 (enrdf_load_stackoverflow) |
| BE (1) | BE805298A (enrdf_load_stackoverflow) |
| CH (1) | CH587275A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2348473A1 (enrdf_load_stackoverflow) |
| DK (1) | DK132409C (enrdf_load_stackoverflow) |
| FR (1) | FR2202093B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1426557A (enrdf_load_stackoverflow) |
| NL (1) | NL7313636A (enrdf_load_stackoverflow) |
| SE (1) | SE402774B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0051457A3 (en) * | 1980-11-03 | 1982-09-15 | Eli Lilly And Company | Process for preparation of substituted benzyl esters |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5481262A (en) * | 1977-12-06 | 1979-06-28 | Oce Andeno Bv | Manufacture of 33thienylmaloic acid or its diester |
| JPH02142917U (enrdf_load_stackoverflow) * | 1989-05-01 | 1990-12-04 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3651050A (en) * | 1969-01-23 | 1972-03-21 | Pfizer | Acylation of 6-aminopenicillanic acid and 7-aminocephalosporanic acid |
-
1972
- 1972-10-05 GB GB4593672A patent/GB1426557A/en not_active Expired
-
1973
- 1973-09-25 BE BE136034A patent/BE805298A/xx not_active IP Right Cessation
- 1973-09-26 DE DE19732348473 patent/DE2348473A1/de active Pending
- 1973-09-26 FR FR7334471A patent/FR2202093B1/fr not_active Expired
- 1973-10-03 SE SE7313478A patent/SE402774B/xx unknown
- 1973-10-04 JP JP11109173A patent/JPS5745226B2/ja not_active Expired
- 1973-10-04 DK DK540573A patent/DK132409C/da active
- 1973-10-04 NL NL7313636A patent/NL7313636A/xx unknown
- 1973-10-04 CH CH1418173A patent/CH587275A5/xx not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0051457A3 (en) * | 1980-11-03 | 1982-09-15 | Eli Lilly And Company | Process for preparation of substituted benzyl esters |
Also Published As
| Publication number | Publication date |
|---|---|
| DK132409B (da) | 1975-12-01 |
| FR2202093B1 (enrdf_load_stackoverflow) | 1979-04-13 |
| CH587275A5 (enrdf_load_stackoverflow) | 1977-04-29 |
| DK132409C (da) | 1976-05-03 |
| JPS4992061A (enrdf_load_stackoverflow) | 1974-09-03 |
| DE2348473A1 (de) | 1974-04-18 |
| JPS5745226B2 (enrdf_load_stackoverflow) | 1982-09-27 |
| BE805298A (fr) | 1974-03-25 |
| NL7313636A (enrdf_load_stackoverflow) | 1974-04-09 |
| FR2202093A1 (enrdf_load_stackoverflow) | 1974-05-03 |
| SE402774B (sv) | 1978-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |