GB1425972A - System for differentiating particles - Google Patents

System for differentiating particles

Info

Publication number
GB1425972A
GB1425972A GB3378673A GB3378673A GB1425972A GB 1425972 A GB1425972 A GB 1425972A GB 3378673 A GB3378673 A GB 3378673A GB 3378673 A GB3378673 A GB 3378673A GB 1425972 A GB1425972 A GB 1425972A
Authority
GB
United Kingdom
Prior art keywords
nuclei
measurements
signal
flow tube
determined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3378673A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Block Engineering Inc
Original Assignee
Block Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Block Engineering Inc filed Critical Block Engineering Inc
Publication of GB1425972A publication Critical patent/GB1425972A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4711—Multiangle measurement
    • G01N2021/4716—Using a ring of sensors, or a combination of diaphragm and sensors; Annular sensor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
GB3378673A 1972-08-14 1973-07-16 System for differentiating particles Expired GB1425972A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00280271A US3822095A (en) 1972-08-14 1972-08-14 System for differentiating particles

Publications (1)

Publication Number Publication Date
GB1425972A true GB1425972A (en) 1976-02-25

Family

ID=23072378

Family Applications (2)

Application Number Title Priority Date Filing Date
GB3378673A Expired GB1425972A (en) 1972-08-14 1973-07-16 System for differentiating particles
GB2153474A Expired GB1425973A (en) 1972-08-14 1973-07-16 System for differentiating particles

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2153474A Expired GB1425973A (en) 1972-08-14 1973-07-16 System for differentiating particles

Country Status (7)

Country Link
US (1) US3822095A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS4952489A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH583021A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2340843A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2196708A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB1425972A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7311146A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12405204B2 (en) 2022-06-20 2025-09-02 Mehmet Selim Hanay Method and device for identifying the material type of particles in liquid

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3982126A (en) * 1974-03-05 1976-09-21 Outokumpu Oy Method and device for determining particle size categories of particles dispersed in a liquid
US3976862A (en) * 1975-03-18 1976-08-24 Block Engineering, Inc. Flow stream processor
US3960449A (en) * 1975-06-05 1976-06-01 The Board Of Trustees Of Leland Stanford Junior University Measurement of angular dependence of scattered light in a flowing stream
US4070113A (en) * 1976-05-05 1978-01-24 California Institute Of Technology Coherent optics blood cell classification system
US4184766A (en) * 1976-10-28 1980-01-22 Coulter Electronics, Inc. Method and apparatus for correlating measurements of tandem sensing zones
DE2903625A1 (de) * 1978-02-03 1979-08-09 Rush Presbyterian St Luke Vorrichtung zur automatischen blutanalyse
SE7806922L (sv) * 1978-06-15 1979-12-16 Svenska Traeforskningsinst Forfarande och anordning for att indikera storleksfordelningen av i ett strommande medium befintliga partiklar
US4455376A (en) * 1979-09-17 1984-06-19 R. J. Harvey Instrument Corp. Photometric methods for counting the particulate components of blood
US4338024A (en) * 1980-05-02 1982-07-06 International Remote Imaging Systems, Inc. Flow analyzer and system for analysis of fluids with particles
FR2484077B1 (fr) * 1980-06-06 1984-07-06 Inst Nat Sante Rech Med Procede et dispositif de mesure de la deformabilite de cellules vivantes, notamment des globules rouges du sang
EP0046345A3 (en) * 1980-08-15 1982-03-03 Ortho Diagnostic Systems Inc. Controlled hydrodynamic flow in flow cytometry systems
SE453128B (sv) * 1981-10-01 1988-01-11 Svenska Traeforskningsinst Forfarande for att bestemma medelpartikelradie och/eller medelpartikellengd
US4798465B2 (en) * 1986-04-14 1994-08-30 Particle Measuring Syst Particle size detection device having high sensitivity in high molecular scattering environment
US4983038A (en) * 1987-04-08 1991-01-08 Hitachi, Ltd. Sheath flow type flow-cell device
JP2635125B2 (ja) * 1988-09-30 1997-07-30 東亜医用電子株式会社 核の分葉指数を求めるための粒子分析装置及び方法
US5123055A (en) * 1989-08-10 1992-06-16 International Remote Imaging Systems, Inc. Method and an apparatus for differentiating a sample of biological cells
US6812032B1 (en) * 1993-01-21 2004-11-02 Cdc Technologies, Inc. Apparatus and method for making a plurality of reagent mixtures and analyzing particle distributions of the reagent mixtures
US5728351A (en) * 1993-01-21 1998-03-17 Cdc Technologies, Inc. Apparatus for making a plurality of reagent mixtures and analyzing particle distributions of the reagent mixtures
JP3039594B2 (ja) * 1993-10-08 2000-05-08 株式会社日立製作所 染色試薬およびその使用方法
US5840254A (en) 1995-06-02 1998-11-24 Cdc Technologies, Inc. Apparatus for mixing fluids for analysis
US6118531A (en) * 1997-05-03 2000-09-12 Hertel; Martin Method for identifying particles in a gaseous or liquid carrier medium
US6020960A (en) * 1998-02-25 2000-02-01 Honeywell Inc. System for the in-line extraction and dilution of a representative sample of a processed medium
US6359683B1 (en) * 2000-04-27 2002-03-19 Becton, Dickinson And Company Method for determining the volume of particles suspended in liquids
US7420659B1 (en) 2000-06-02 2008-09-02 Honeywell Interantional Inc. Flow control system of a cartridge
US6970245B2 (en) * 2000-08-02 2005-11-29 Honeywell International Inc. Optical alignment detection system
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US7283223B2 (en) * 2002-08-21 2007-10-16 Honeywell International Inc. Cytometer having telecentric optics
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US20060263888A1 (en) * 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US8071051B2 (en) 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
US7130046B2 (en) * 2004-09-27 2006-10-31 Honeywell International Inc. Data frame selection for cytometer analysis
US7242474B2 (en) * 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
US6700130B2 (en) * 2001-06-29 2004-03-02 Honeywell International Inc. Optical detection system for flow cytometry
US7641856B2 (en) * 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US8383043B2 (en) * 2004-05-14 2013-02-26 Honeywell International Inc. Analyzer system
US7262838B2 (en) * 2001-06-29 2007-08-28 Honeywell International Inc. Optical detection system for flow cytometry
US7016022B2 (en) * 2000-08-02 2006-03-21 Honeywell International Inc. Dual use detectors for flow cytometry
US7471394B2 (en) * 2000-08-02 2008-12-30 Honeywell International Inc. Optical detection system with polarizing beamsplitter
US7215425B2 (en) * 2000-08-02 2007-05-08 Honeywell International Inc. Optical alignment for flow cytometry
US7978329B2 (en) * 2000-08-02 2011-07-12 Honeywell International Inc. Portable scattering and fluorescence cytometer
US7061595B2 (en) * 2000-08-02 2006-06-13 Honeywell International Inc. Miniaturized flow controller with closed loop regulation
US7277166B2 (en) * 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US7612871B2 (en) * 2004-09-01 2009-11-03 Honeywell International Inc Frequency-multiplexed detection of multiple wavelength light for flow cytometry
US7630075B2 (en) * 2004-09-27 2009-12-08 Honeywell International Inc. Circular polarization illumination based analyzer system
WO2006119106A1 (en) 2005-04-29 2006-11-09 Honeywell International Inc. Cytometer cell counting and size measurement method
US8273294B2 (en) * 2005-07-01 2012-09-25 Honeywell International Inc. Molded cartridge with 3-D hydrodynamic focusing
WO2007005974A2 (en) * 2005-07-01 2007-01-11 Honeywell International, Inc. A flow metered analyzer
EP1901846B1 (en) * 2005-07-01 2015-01-14 Honeywell International Inc. A microfluidic card for rbc analysis
US7843563B2 (en) * 2005-08-16 2010-11-30 Honeywell International Inc. Light scattering and imaging optical system
EP1963819A2 (en) * 2005-12-22 2008-09-03 Honeywell International, Inc. Portable sample analyzer system
EP1963817A2 (en) * 2005-12-22 2008-09-03 Honeywell International Inc. Portable sample analyzer cartridge
CN101389947B (zh) * 2005-12-29 2013-08-21 霍尼韦尔国际公司 微流格式的测定工具
EP2232229B1 (en) 2007-12-04 2021-02-17 Particle Measuring Systems, Inc. Two-dimensional optical imaging methods for particle detection
US8742368B2 (en) 2008-02-01 2014-06-03 Cambridge Consultants Limited Device and method for measuring scattering of radiation
US20100034704A1 (en) * 2008-08-06 2010-02-11 Honeywell International Inc. Microfluidic cartridge channel with reduced bubble formation
US8037354B2 (en) 2008-09-18 2011-10-11 Honeywell International Inc. Apparatus and method for operating a computing platform without a battery pack
EP2194368B1 (de) * 2008-12-03 2019-07-17 Grundfos Management A/S Sensorsystem zum Erfassen und Spezifizieren von einzelnen Partikeln in einem Fluid
US8741235B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Two step sample loading of a fluid analysis cartridge
US8741234B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
US8741233B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
US8663583B2 (en) 2011-12-27 2014-03-04 Honeywell International Inc. Disposable cartridge for fluid analysis
US9857361B2 (en) 2013-03-15 2018-01-02 Iris International, Inc. Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples
BR112015021902B1 (pt) 2013-03-15 2021-06-15 Iris International, Inc Líquido para alinhamento de partícula e organela intracelular
CN105074422B (zh) * 2013-03-15 2019-07-09 艾瑞思国际股份有限公司 用于染色和样品处理的方法和组合物
US9714897B2 (en) 2015-02-09 2017-07-25 Slingshot Biosciences, Inc. Hydrogel particles with tunable optical properties and methods for using the same
KR101855490B1 (ko) * 2016-01-22 2018-05-08 한국과학기술원 점탄성유체와 점성유체의 병행층류를 이용한 미소 입자 분리 및 세정 방법
WO2019182060A1 (ja) * 2018-03-22 2019-09-26 住友電気工業株式会社 光ファイバの製造方法および製造装置
AU2021209907A1 (en) 2020-01-24 2022-07-07 Slingshot Biosciences, Inc. Compositions and methods for cell-like calibration particles
CA3177834A1 (en) 2020-05-04 2021-11-11 Jeffrey Kim Compositions and methods for passive optical barcoding for multiplexed assays
KR20240116721A (ko) 2021-10-29 2024-07-30 슬링샷 바이오사이언시즈 인코포레이티드 피더 세포 및 합성 항원 제시 세포로서의 하이드로겔 입자
WO2023215886A1 (en) 2022-05-05 2023-11-09 Slingshot Biosciences, Inc. Engineered particles as red blood cell mimics and compositions containing same for hematology
EP4531813A1 (en) 2022-06-02 2025-04-09 Slingshot Biosciences, Inc. Apoptotic cell mimic
WO2024092161A2 (en) 2022-10-26 2024-05-02 Slingshot Biosciences, Inc. Size-tunable synthetic particles with tunable optical properties and methods for using the same for immune cell activation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3327117A (en) * 1963-08-12 1967-06-20 Ibm Cancer cell detector using two wavelengths for comparison
US3315229A (en) * 1963-12-31 1967-04-18 Ibm Blood cell recognizer
NL6702923A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1966-04-06 1967-10-09
US3699336A (en) * 1969-08-15 1972-10-17 Hycel Inc Biological cell analyzing system
US3662176A (en) * 1970-04-06 1972-05-09 Bio Physics Systems Inc Photo-optical particle analysis method and apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12405204B2 (en) 2022-06-20 2025-09-02 Mehmet Selim Hanay Method and device for identifying the material type of particles in liquid

Also Published As

Publication number Publication date
CH583021A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-12-31
AU5838273A (en) 1975-01-23
US3822095A (en) 1974-07-02
FR2196708A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-03-15
NL7311146A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-02-18
DE2340843A1 (de) 1974-02-28
JPS4952489A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-05-21
GB1425973A (en) 1976-02-25

Similar Documents

Publication Publication Date Title
GB1425972A (en) System for differentiating particles
CN106018280B (zh) 一种同时测量速度场和浓度场的装置和方法
US3819270A (en) Blood cell analyzer
US4265538A (en) Optical sample cell for analysis of particles in liquid suspension
US4728190A (en) Device and method for optically detecting particles in a fluid
US3508830A (en) Apparatus for light scattering measurements
JP2777536B2 (ja) 散乱光測定用のサンプル・セル及びサンプル・セル・モニタ
US2873644A (en) Optical system for the measurement of turbidity
JP2911877B2 (ja) 懸濁液の散乱光或いは蛍光を検出するためのファイバー検出器
US2240988A (en) Liquid level indicator
Horvath Comparison of measurements of aerosol optical absorption by filter collection and a transmissometric method
CA1153579A (en) Optical reflection meter
US5006986A (en) Method of demarcating two-dimensional distribution
US5572321A (en) Detector for measuring the luminous intensity scattered by thin films of colloidal media
US3907437A (en) Cell classification system
Macfadyen et al. Fibre-optic systems for dynamic light scattering—a review
CN114966730B (zh) 一种基于双入射角混频的激光多普勒测速方法及系统
Donelli et al. Experimental validation of a Monte Carlo procedure for the evaluation of the effect of a turbid medium on the point spread function of an optical system
CN101290281A (zh) 一种三光束单镜头激光粒度仪
US4225232A (en) Photometric cell
JPS61221633A (ja) フローサイトメータ
JPS5720636A (en) Measuring device for transmittance of lens
US5157252A (en) Photometer arrangement with scattered light trap
CN111537414A (zh) 一种液体光学腔增强测量系统
CN118348548B (zh) 多光束混频的激光多普勒测速方法及系统

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees