GB1424789A - Process for the preparation of benzylidene derivatives - Google Patents
Process for the preparation of benzylidene derivativesInfo
- Publication number
- GB1424789A GB1424789A GB4563174A GB4563174A GB1424789A GB 1424789 A GB1424789 A GB 1424789A GB 4563174 A GB4563174 A GB 4563174A GB 4563174 A GB4563174 A GB 4563174A GB 1424789 A GB1424789 A GB 1424789A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- benzaldehyde
- hydrazine
- aminopyridazine
- preferably effected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1424789 3 - Benzylidenehydrazino - 6 - (2- hydroxypropyl) - aminopyridazine derivatives ISF SpA 22 Oct 1974 [9 May 1974] 45631/74 Heading C2C Compounds of Formula I in which R is a C 1-3 alkyl radical optionally substituted by a hydroxyl group, are obtained by reacting a thiopyridazine of Formula II in which X is -Cl, -Br or -SCH 3 , with an aminoalcohol of Formula III R-NH-CH 2 -CH(OH)-CH 3 to give an aminopyridazine of Formula IV which is then reacted with hydrazine (e.g. the hydrate) and thereafter with benzaldehyde. All of the steps are preferably effected with heating (e.g. under reflux) and the reaction to produce IV is generally carried out in an inert organic solvent (e.g. toluene or a xylene). The reactions with hydrazine and benzaldehyde are preferably effected in an aprotic solvent (e.g. DMF) and the last step generally at pH 3 to 6.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2248674 | 1974-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1424789A true GB1424789A (en) | 1976-02-11 |
Family
ID=11196911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4563174A Expired GB1424789A (en) | 1974-05-09 | 1974-10-22 | Process for the preparation of benzylidene derivatives |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS50142579A (en) |
AR (1) | AR201706A1 (en) |
BE (1) | BE821389A (en) |
DE (1) | DE2450873A1 (en) |
ES (1) | ES431009A1 (en) |
FR (1) | FR2270248B1 (en) |
GB (1) | GB1424789A (en) |
ZA (1) | ZA746669B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU176972B (en) * | 1977-06-13 | 1981-06-28 | Gyogyszerkutato Intezet | Process for producing new piridazinyl-hydrasone derivatives |
EP0009655B1 (en) * | 1978-10-02 | 1983-05-11 | Gruppo Lepetit S.P.A. | 6-amino substituted n-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them |
HU179191B (en) * | 1979-05-07 | 1982-09-28 | Gyogyszerkutato Intezet | New process for preparing 6-/substituted amino/-3-pyridazinyl-hydrazines and salts thereof |
-
1974
- 1974-10-15 ES ES431009A patent/ES431009A1/en not_active Expired
- 1974-10-21 ZA ZA00746669A patent/ZA746669B/en unknown
- 1974-10-22 GB GB4563174A patent/GB1424789A/en not_active Expired
- 1974-10-22 FR FR7435414A patent/FR2270248B1/fr not_active Expired
- 1974-10-23 AR AR256202A patent/AR201706A1/en active
- 1974-10-23 JP JP49121545A patent/JPS50142579A/ja active Pending
- 1974-10-23 BE BE149804A patent/BE821389A/en unknown
- 1974-10-25 DE DE19742450873 patent/DE2450873A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2270248B1 (en) | 1977-07-08 |
ZA746669B (en) | 1975-11-26 |
AR201706A1 (en) | 1975-04-08 |
BE821389A (en) | 1975-02-17 |
FR2270248A1 (en) | 1975-12-05 |
JPS50142579A (en) | 1975-11-17 |
DE2450873A1 (en) | 1975-11-13 |
ES431009A1 (en) | 1976-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |