GB1423932A - 4-amino-quinolines - Google Patents

4-amino-quinolines

Info

Publication number
GB1423932A
GB1423932A GB1101074A GB1101074A GB1423932A GB 1423932 A GB1423932 A GB 1423932A GB 1101074 A GB1101074 A GB 1101074A GB 1101074 A GB1101074 A GB 1101074A GB 1423932 A GB1423932 A GB 1423932A
Authority
GB
United Kingdom
Prior art keywords
compound
trifluoromethylthio
march
dihydroxypropyl
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1101074A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB1423932A publication Critical patent/GB1423932A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1423932 4 - Amino - 8 - trifluoromethylthio-quinoline derivatives ROUSSEL-UCLAF 12 March 1974 [12 March 1973] 11010/74 Heading C2C Novel compounds (I) (including salts thereof) where X is H, C 1 to C 6 alkyl, 2,3-dihydroxypropyl, 2,3-isopropylidenedioxypropyl, pivaloyloxymethyl or o-carboxyphenyl, are made by interacting 4-choro-8-trifluoro-methylthio-quinoline (obtained by treating the 4-hydroxy compound with POCl 3 ) and methyl anthranilate to give (I) where X is methyl from which other compounds (I) can be obtained by standard methods; the 2,3-dihydroxypropyl compound can also be prepared by hydrolysing the 2,3- isopropylidene-dioxypropyl compound. Ethyl o - trifluoromethylthioanilinomethylene malonate and 3-carboxy- and -ethoxycarbonyl-4- hydroxy - 8 - trifluoromethylthio - quinolines are also prepared. Pharmaceutical preparations having antiinflammatory and analgesic actions contain (I) as active ingredient.
GB1101074A 1973-03-12 1974-03-12 4-amino-quinolines Expired GB1423932A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7308677A FR2221126B2 (en) 1973-03-12 1973-03-12

Publications (1)

Publication Number Publication Date
GB1423932A true GB1423932A (en) 1976-02-04

Family

ID=9116116

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1101074A Expired GB1423932A (en) 1973-03-12 1974-03-12 4-amino-quinolines

Country Status (6)

Country Link
BE (1) BE812108A (en)
CH (1) CH590237A5 (en)
DE (1) DE2411523A1 (en)
FR (1) FR2221126B2 (en)
GB (1) GB1423932A (en)
NL (1) NL7403217A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2509728A1 (en) * 1981-07-17 1983-01-21 Roussel Uclaf NOVEL QUINOLINE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME

Also Published As

Publication number Publication date
FR2221126A2 (en) 1974-10-11
CH590237A5 (en) 1977-07-29
DE2411523A1 (en) 1974-09-26
NL7403217A (en) 1974-09-16
FR2221126B2 (en) 1977-01-28
BE812108A (en) 1974-09-11

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee