GB1423266A - 2-substituted thio-s-triazolo-1,5-a pyrimidines - Google Patents
2-substituted thio-s-triazolo-1,5-a pyrimidinesInfo
- Publication number
- GB1423266A GB1423266A GB2627973A GB2627973A GB1423266A GB 1423266 A GB1423266 A GB 1423266A GB 2627973 A GB2627973 A GB 2627973A GB 2627973 A GB2627973 A GB 2627973A GB 1423266 A GB1423266 A GB 1423266A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrimidines
- optionally
- triazolo
- ethoxycarbonyl
- june
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1423266 Thio-substituted triazolo-pyrimidines ICN PHARMACEUTICALS Inc 1 June 1973 [7 June 1972] 26279/73 Heading C2C Novel compounds (I) where R is optionally substituted alkyl, aryl or aralkyl, R 1 is Me, halogen, mercapto or an amine group (including hydrazino and saturated N-containing heterocyclic groups) optionally in salt form, R 2 is H or ethoxycarbonyl and R 3 is H or Me provided that when R 2 is ethoxycarbonyl, R 3 is H, are made by reacting (II) with acetylacetone, diethyl ethoxymethylenemalonate or ethyl acetoacetate and, if necessary, alkylating a compound obtained or reacting it with POCl 3 followed optionally with an amine, N 2 H 4 , a substituted hydrazine or NaHS. Pharmaceutical preparations capable of inhibiting the action of phosphodiesterase enzymes contain (I) as active ingredient.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26051772A | 1972-06-07 | 1972-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1423266A true GB1423266A (en) | 1976-02-04 |
Family
ID=22989482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2627973A Expired GB1423266A (en) | 1972-06-07 | 1973-06-01 | 2-substituted thio-s-triazolo-1,5-a pyrimidines |
Country Status (7)
Country | Link |
---|---|
BE (1) | BE800550A (en) |
CA (1) | CA1010863A (en) |
DE (1) | DE2327133A1 (en) |
ES (1) | ES415389A1 (en) |
FR (1) | FR2187295B1 (en) |
GB (1) | GB1423266A (en) |
NL (1) | NL7307573A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0500136A1 (en) * | 1991-02-22 | 1992-08-26 | Egis Gyogyszergyar | 1,2,4-Triazolo[1,5-a]pyrimidine derivatives, a process for preparing them as well as medicaments containing them and the use of them |
EP0500137A1 (en) * | 1991-02-22 | 1992-08-26 | Egis Gyogyszergyar | 1,2,4-Triazolo[1,5-a]pyrimidine derivatives, a process for preparing them as well as medicaments containing them and the use of them |
US5478825A (en) * | 1991-02-22 | 1995-12-26 | Egis Gyogyszergyar | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives |
CN106478639A (en) * | 2016-09-05 | 2017-03-08 | 郑州大学 | The LSD1 inhibitor of pyrimido 1,2,4 triazole, its preparation method and application |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL73486A (en) * | 1983-11-14 | 1993-05-13 | Dow Chemical Co | N-aryl 1,2,4-triazolo (1,5-a) pyrimidine-2-sulfonamides, their preparation and compositions and methods of controlling undesired vegetation and suppressing the nitrification of ammonium nitrogen in soil |
DE3627411A1 (en) * | 1986-08-13 | 1988-02-18 | Bayer Ag | TRIAZOLO-PYRIMIDINE-2-SULPHONAMIDE |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE566543A (en) * | 1957-04-09 | |||
JPS503170B1 (en) * | 1970-06-11 | 1975-01-31 |
-
1973
- 1973-05-28 DE DE19732327133 patent/DE2327133A1/en active Pending
- 1973-05-30 NL NL7307573A patent/NL7307573A/xx unknown
- 1973-05-30 ES ES415389A patent/ES415389A1/en not_active Expired
- 1973-06-01 GB GB2627973A patent/GB1423266A/en not_active Expired
- 1973-06-06 FR FR7320569A patent/FR2187295B1/fr not_active Expired
- 1973-06-06 BE BE131957A patent/BE800550A/en unknown
- 1973-06-07 CA CA173,489A patent/CA1010863A/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0500136A1 (en) * | 1991-02-22 | 1992-08-26 | Egis Gyogyszergyar | 1,2,4-Triazolo[1,5-a]pyrimidine derivatives, a process for preparing them as well as medicaments containing them and the use of them |
EP0500137A1 (en) * | 1991-02-22 | 1992-08-26 | Egis Gyogyszergyar | 1,2,4-Triazolo[1,5-a]pyrimidine derivatives, a process for preparing them as well as medicaments containing them and the use of them |
US5478825A (en) * | 1991-02-22 | 1995-12-26 | Egis Gyogyszergyar | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives |
CN106478639A (en) * | 2016-09-05 | 2017-03-08 | 郑州大学 | The LSD1 inhibitor of pyrimido 1,2,4 triazole, its preparation method and application |
Also Published As
Publication number | Publication date |
---|---|
FR2187295A1 (en) | 1974-01-18 |
BE800550A (en) | 1973-10-01 |
FR2187295B1 (en) | 1976-12-31 |
CA1010863A (en) | 1977-05-24 |
NL7307573A (en) | 1973-12-11 |
ES415389A1 (en) | 1976-06-01 |
AU5588273A (en) | 1974-11-21 |
DE2327133A1 (en) | 1974-01-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |