GB1271147A - Novel 2,3-disubstituted quinazolinone derivatives - Google Patents
Novel 2,3-disubstituted quinazolinone derivativesInfo
- Publication number
- GB1271147A GB1271147A GB5571669A GB5571669A GB1271147A GB 1271147 A GB1271147 A GB 1271147A GB 5571669 A GB5571669 A GB 5571669A GB 5571669 A GB5571669 A GB 5571669A GB 1271147 A GB1271147 A GB 1271147A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- pyridyl
- nov
- compound
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- UYXAWHWODHRRMR-UHFFFAOYSA-N hexobarbital Chemical compound O=C1N(C)C(=O)NC(=O)C1(C)C1=CCCCC1 UYXAWHWODHRRMR-UHFFFAOYSA-N 0.000 abstract 1
- 229960002456 hexobarbital Drugs 0.000 abstract 1
- 125000002636 imidazolinyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003533 narcotic effect Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1,271,147. Pharmaceutical compositions containing quinazolinones. EGYESULT GYOGYSZER-ES TAPSZERGYAR. 13 Nov., 1969 [28 Nov., 1968], No. 55716/69. Heading ASB. [Also in Division C2] Pharmaceutical compositions which_exert a selective blocking activity on drug-metabolising enzyme systems comprise, besides a physiologically compatible carrier or excipient, a , compound of formula: or an acid addition or quaternary ammonium salt thereof, wherein R<SP>1</SP>. is C 1-4 alkyl; and R' is C 1-4 alkyl or C 1-4 alkylamino, each of which is substituted by pyridyl, (C 1-4 -alkyl) pyridyl, furyl, (C 1-4 -alkyl) imidazolinyl or piperizinyl, but the compound in which R<SP>1</SP> is Me and R<SP>2</SP> is pyridylmethyl is excluded. The compositions, which optionally contain also a narcotic, enhance the effect of e.g. hexobarbital.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUEE001598 | 1968-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1271147A true GB1271147A (en) | 1972-04-19 |
Family
ID=10995280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5571669A Expired GB1271147A (en) | 1968-11-28 | 1969-11-13 | Novel 2,3-disubstituted quinazolinone derivatives |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE1957319A1 (en) |
| DK (1) | DK124755B (en) |
| FR (1) | FR2024433A1 (en) |
| GB (1) | GB1271147A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0620218A1 (en) * | 1993-04-16 | 1994-10-19 | ALFA WASSERMANN S.p.A. | Heterocyclic compounds active in gastro-intestinal pathologies |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2730174C2 (en) * | 1977-07-04 | 1981-12-10 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | Aminobenzoic acid derivatives and medicaments containing such aminobenzoic acid derivatives |
| US4753944A (en) * | 1985-11-04 | 1988-06-28 | American Cyanamid Company | Pharmaceutical methods of using 3-heteroarylalkyl-4-quinazolinones |
| US4680293A (en) * | 1986-03-03 | 1987-07-14 | American Cyanamid Company | 3-imidazolylalkyl-, triazolylalkyl-, pyridinylalkyl-1,2,3-benzotriazin-4(3H)-ones and derivatives thereof |
-
1969
- 1969-11-13 GB GB5571669A patent/GB1271147A/en not_active Expired
- 1969-11-14 DE DE19691957319 patent/DE1957319A1/en active Pending
- 1969-11-27 FR FR6940980A patent/FR2024433A1/en not_active Withdrawn
- 1969-11-27 DK DK630769A patent/DK124755B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0620218A1 (en) * | 1993-04-16 | 1994-10-19 | ALFA WASSERMANN S.p.A. | Heterocyclic compounds active in gastro-intestinal pathologies |
Also Published As
| Publication number | Publication date |
|---|---|
| DK124755B (en) | 1972-11-20 |
| DE1957319A1 (en) | 1970-06-11 |
| FR2024433A1 (en) | 1970-08-28 |
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