GB1422899A - S-heterocyclic derivatives of phosphine or phosphite gold mercaptides and anti-arthritic compositions comprising them - Google Patents
S-heterocyclic derivatives of phosphine or phosphite gold mercaptides and anti-arthritic compositions comprising themInfo
- Publication number
- GB1422899A GB1422899A GB3376374A GB3376374A GB1422899A GB 1422899 A GB1422899 A GB 1422899A GB 3376374 A GB3376374 A GB 3376374A GB 3376374 A GB3376374 A GB 3376374A GB 1422899 A GB1422899 A GB 1422899A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phosphine
- gold
- phosphite
- mercaptides
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 title abstract 7
- 229910000073 phosphorus hydride Inorganic materials 0.000 title abstract 4
- XDGCJGXFGCYHEK-UHFFFAOYSA-N [Au+3].[O-]P([O-])[O-] Chemical compound [Au+3].[O-]P([O-])[O-] XDGCJGXFGCYHEK-UHFFFAOYSA-N 0.000 title abstract 3
- 230000002456 anti-arthritic effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 229910003771 Gold(I) chloride Inorganic materials 0.000 abstract 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000012298 atmosphere Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Substances ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 1
- DCVQRCZEVHAMBN-UHFFFAOYSA-M chlorogold;diethyl(phenyl)phosphane Chemical compound [Au]Cl.CCP(CC)C1=CC=CC=C1 DCVQRCZEVHAMBN-UHFFFAOYSA-M 0.000 abstract 1
- LVTCZSBUROAWTE-UHFFFAOYSA-N diethyl(phenyl)phosphane Chemical compound CCP(CC)C1=CC=CC=C1 LVTCZSBUROAWTE-UHFFFAOYSA-N 0.000 abstract 1
- 239000010931 gold Substances 0.000 abstract 1
- 229910052737 gold Inorganic materials 0.000 abstract 1
- -1 gold halide Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000012299 nitrogen atmosphere Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- YODZTKMDCQEPHD-UHFFFAOYSA-N thiodiglycol Chemical compound OCCSCCO YODZTKMDCQEPHD-UHFFFAOYSA-N 0.000 abstract 1
- 229950006389 thiodiglycol Drugs 0.000 abstract 1
- XYYVDQWGDNRQDA-UHFFFAOYSA-K trichlorogold;trihydrate;hydrochloride Chemical compound O.O.O.Cl.Cl[Au](Cl)Cl XYYVDQWGDNRQDA-UHFFFAOYSA-K 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US384666A US3883546A (en) | 1973-08-01 | 1973-08-01 | S-heterocyclic derivatives of phosphine or phosphite gold mercaptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1422899A true GB1422899A (en) | 1976-01-28 |
Family
ID=23518252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3376374A Expired GB1422899A (en) | 1973-08-01 | 1974-07-31 | S-heterocyclic derivatives of phosphine or phosphite gold mercaptides and anti-arthritic compositions comprising them |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3883546A (enExample) |
| JP (1) | JPS5761035B2 (enExample) |
| BE (1) | BE818218A (enExample) |
| CA (1) | CA1054609A (enExample) |
| DE (1) | DE2437147C2 (enExample) |
| FR (1) | FR2240014B1 (enExample) |
| GB (1) | GB1422899A (enExample) |
| SE (1) | SE7409800L (enExample) |
| ZA (1) | ZA744598B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4165380A (en) * | 1977-02-25 | 1979-08-21 | Smithkline Corporation | Bis(sulfide)gold(1+) salts |
| US4172833A (en) * | 1978-03-20 | 1979-10-30 | R. T. Vanderbilt Company, Inc. | Process for preparation of 2-mercaptotoluimidazole and salts thereof |
| WO1985000747A1 (en) * | 1983-08-10 | 1985-02-28 | Stockel Richard F | Use of selenium-containing compounds for negating the toxic effects of gold compounds used in the treatment of rheumatoid arthritis, and a novel selenium-containing gold compound and use thereof as an anti-rheumatoid arthritis medicine |
| EA201692189A1 (ru) * | 2014-05-28 | 2017-02-28 | Осферикс Лимитед | Соединения фосфина золота (i) в качестве антибактериальных агентов |
| JP2017519817A (ja) * | 2014-05-28 | 2017-07-20 | オースフェリクス・リミテッドＡｕｓｐｈｅｒｉｘ Ｌｉｍｉｔｅｄ | 抗菌薬としての金（ｉ）−ホスフィン化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL131206C (enExample) * | 1965-09-03 | |||
| US3755329A (en) * | 1970-12-22 | 1973-08-28 | Du Pont | Nitrogen-heterocyclylgold(i) compounds |
-
1973
- 1973-08-01 US US384666A patent/US3883546A/en not_active Expired - Lifetime
-
1974
- 1974-07-18 ZA ZA00744598A patent/ZA744598B/xx unknown
- 1974-07-26 JP JP49085967A patent/JPS5761035B2/ja not_active Expired
- 1974-07-29 BE BE147055A patent/BE818218A/xx not_active IP Right Cessation
- 1974-07-30 SE SE7409800A patent/SE7409800L/xx unknown
- 1974-07-31 GB GB3376374A patent/GB1422899A/en not_active Expired
- 1974-07-31 CA CA206060A patent/CA1054609A/en not_active Expired
- 1974-08-01 DE DE2437147A patent/DE2437147C2/de not_active Expired
- 1974-08-01 FR FR7426773A patent/FR2240014B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2240014A1 (enExample) | 1975-03-07 |
| JPS5041859A (enExample) | 1975-04-16 |
| AU7180774A (en) | 1976-02-05 |
| CA1054609A (en) | 1979-05-15 |
| US3883546A (en) | 1975-05-13 |
| BE818218A (fr) | 1975-01-29 |
| ZA744598B (en) | 1975-07-30 |
| FR2240014B1 (enExample) | 1978-07-21 |
| DE2437147A1 (de) | 1975-02-13 |
| DE2437147C2 (de) | 1983-03-03 |
| SE7409800L (enExample) | 1975-02-03 |
| JPS5761035B2 (enExample) | 1982-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |