GB1420842A - Preparation of 2,4-diamino-5- 3,4,5-trimethoxybenzyl-pyrimidine - Google Patents

Preparation of 2,4-diamino-5- 3,4,5-trimethoxybenzyl-pyrimidine

Info

Publication number
GB1420842A
GB1420842A GB837973A GB837973A GB1420842A GB 1420842 A GB1420842 A GB 1420842A GB 837973 A GB837973 A GB 837973A GB 837973 A GB837973 A GB 837973A GB 1420842 A GB1420842 A GB 1420842A
Authority
GB
United Kingdom
Prior art keywords
trimethoxybenzyl
pyrimidine
diamino
preparation
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB837973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Farmaceutika dd
Original Assignee
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB837972A priority Critical patent/GB1387881A/en
Application filed by Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Publication of GB1420842A publication Critical patent/GB1420842A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1420842 Pyrimidine derivative PLIVA PHARMACEUTICAL & CHEMICAL WORKS 20 Feb 1973 [8 May 1972] 8379/73 Heading C2C 2,4 - Diamino - 5 - (3,4,5 - trimethoxybenzyl)- pyrimidine is prepared by reacting a compound of the formula (X Y=OH, acetamido) with phosphorus oxychloride, trichloride or pentachloride, if necessary aminating and/or hydrolysing the product of the formula (Z, W=Cl, NH 2 , acetamido) and dechlorinating the resulting 2,4-diamino-5-(3,4,5-trimethoxybenzyl) - 6 - chloropyrimidine by catalytic hydrogenation. The preparation of the starting materials and 2-amino-4,6-dihydroxy- and 4-amino-2,6-dihydroxy - 5 - (3,4,5 - trimethoxybenzyl)pyrimidine is described.
GB837973A 1972-05-08 1973-02-20 Preparation of 2,4-diamino-5- 3,4,5-trimethoxybenzyl-pyrimidine Expired GB1420842A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB837972A GB1387881A (en) 1973-02-20 1972-02-23 Apparatus for handling material

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU1211/72A YU34880B (en) 1972-05-08 1972-05-08 Process for preparing 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine

Publications (1)

Publication Number Publication Date
GB1420842A true GB1420842A (en) 1976-01-14

Family

ID=25553232

Family Applications (1)

Application Number Title Priority Date Filing Date
GB837973A Expired GB1420842A (en) 1972-05-08 1973-02-20 Preparation of 2,4-diamino-5- 3,4,5-trimethoxybenzyl-pyrimidine

Country Status (7)

Country Link
AT (1) AT326665B (en)
CA (1) CA1035772A (en)
CH (1) CH592635A5 (en)
DE (1) DE2309760A1 (en)
FR (1) FR2183769B1 (en)
GB (1) GB1420842A (en)
YU (1) YU34880B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1138146B (en) * 1981-08-11 1986-09-17 Proter Spa PROCESS FOR THE PRODUCTION OF 2,4-DIAMINE- (3,5-DIMETHOXY-4-METOS SIETOXY-BENZYL) -PYRIMIDINE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1459417A (en) * 1964-11-12 1966-04-29 Hoffmann La Roche Process for the preparation of pyrimidine derivatives
DE2165362A1 (en) * 1970-12-29 1972-07-27 Nisshin Flour Milling Co. Ltd., Tokio 5-benzyl-2,4-diaminopyrimidines prepn - by 5-stage process from benzaldehydes and alkyl cyanoacetates

Also Published As

Publication number Publication date
CH592635A5 (en) 1977-10-31
FR2183769B1 (en) 1978-02-10
YU34880B (en) 1980-04-30
ATA133873A (en) 1975-03-15
FR2183769A1 (en) 1973-12-21
DE2309760A1 (en) 1973-11-22
CA1035772A (en) 1978-08-01
AT326665B (en) 1975-12-29
YU121172A (en) 1979-10-31

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee