GB1420310A - Oxindole diamine derivatives and a process for their preparation - Google Patents
Oxindole diamine derivatives and a process for their preparationInfo
- Publication number
- GB1420310A GB1420310A GB5549072A GB5549072A GB1420310A GB 1420310 A GB1420310 A GB 1420310A GB 5549072 A GB5549072 A GB 5549072A GB 5549072 A GB5549072 A GB 5549072A GB 1420310 A GB1420310 A GB 1420310A
- Authority
- GB
- United Kingdom
- Prior art keywords
- present
- amount
- isatin derivative
- reaction product
- oxindole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Indole Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
1420310 Oxindole diamine derivatives CIBAGEIGY AG 1 Dec 1972 [2 Dec 1971] 55490/72 Heading C2C Novel compounds of Formula I where R is an N-C 1 to C 6 alkyl or N-aryl are prepared by (a) reacting an isatin derivative of Formula II with an anilide of Formula III where X is C 1 to C 6 alkyl, aryl or anilino in the presence of a Friedel-Crafts catalyst in an inert solvent at a temperature of from 50‹ to 150‹ C., the isatin derivative being present in an amount ranging from 1% to 15% by weight of the total reaction mixture, the anilide being present in at least a mole equivalent amount based on the amount of the isatin derivative, and the Friedel- Crafts catalyst being present in an amount ranging from 2 to 10 mole equivalents based on the amount of the isatin derivative present in the reaction mixture; (b) precipitating the resultant reaction product from step (a) by dilution with a solvent which is not a solvent for the reaction product from step (a); and (c) hydrolysing the reaction product in an aqueous acidic solution, e.g. acetic acid, water and sulphuric acid.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20430171A | 1971-12-02 | 1971-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1420310A true GB1420310A (en) | 1976-01-07 |
Family
ID=22757365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5549072A Expired GB1420310A (en) | 1971-12-02 | 1972-12-01 | Oxindole diamine derivatives and a process for their preparation |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS4862753A (en) |
DE (1) | DE2258505A1 (en) |
FR (1) | FR2164236A5 (en) |
GB (1) | GB1420310A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003078394A1 (en) * | 2002-03-15 | 2003-09-25 | Eli Lilly And Company | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators |
WO2005097107A3 (en) * | 2004-04-08 | 2006-03-30 | Bioimage As | Diphenyl - indol-2-on compounds and their use in the treatment of cancer |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1296010C (en) * | 1985-12-16 | 1992-02-18 | Patrick F. King | Di- and triarylurethane dye precursors |
-
1972
- 1972-11-29 DE DE19722258505 patent/DE2258505A1/en active Pending
- 1972-12-01 GB GB5549072A patent/GB1420310A/en not_active Expired
- 1972-12-01 JP JP12111072A patent/JPS4862753A/ja active Pending
- 1972-12-01 FR FR7242794A patent/FR2164236A5/fr not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003078394A1 (en) * | 2002-03-15 | 2003-09-25 | Eli Lilly And Company | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators |
US7250442B2 (en) | 2002-03-15 | 2007-07-31 | Eli Lilly And Company | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators |
WO2005097107A3 (en) * | 2004-04-08 | 2006-03-30 | Bioimage As | Diphenyl - indol-2-on compounds and their use in the treatment of cancer |
Also Published As
Publication number | Publication date |
---|---|
FR2164236A5 (en) | 1973-07-27 |
DE2258505A1 (en) | 1973-06-07 |
JPS4862753A (en) | 1973-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |