GB1418354A - Tricyclicicazaindole hypoglycemic agents - Google Patents
Tricyclicicazaindole hypoglycemic agentsInfo
- Publication number
- GB1418354A GB1418354A GB423373A GB423373A GB1418354A GB 1418354 A GB1418354 A GB 1418354A GB 423373 A GB423373 A GB 423373A GB 423373 A GB423373 A GB 423373A GB 1418354 A GB1418354 A GB 1418354A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- carbon atoms
- compounds
- alkyl
- hypoglycemic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003472 antidiabetic agent Substances 0.000 title abstract 2
- 229940126904 hypoglycaemic agent Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00228743A US3833591A (en) | 1972-02-23 | 1972-02-23 | 1,3,4,5-tetrahydropyrrolo(4,3,2-d,e)isoquinolines and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1418354A true GB1418354A (en) | 1975-12-17 |
Family
ID=22858420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB423373A Expired GB1418354A (en) | 1972-02-23 | 1973-01-26 | Tricyclicicazaindole hypoglycemic agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3833591A (enrdf_load_stackoverflow) |
| JP (1) | JPS5516434B2 (enrdf_load_stackoverflow) |
| BE (1) | BE795451A (enrdf_load_stackoverflow) |
| DE (1) | DE2306605A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2181738B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1418354A (enrdf_load_stackoverflow) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3900477A (en) * | 1973-11-06 | 1975-08-19 | Ayerst Mckenna & Harrison | 5-amino-and 5-hydrazinodihydropyrroloisoquinoline derivatives |
| US3978066A (en) * | 1973-11-06 | 1976-08-31 | Ayerst, Mckenna And Harrison Ltd. | Certain 4,6-dihydropyrrolotriazoline-quinoline derivatives |
| US3950343A (en) * | 1973-11-06 | 1976-04-13 | Ayerst, Mckenna And Harrison Ltd. | Pyrroloisoquinoline derivatives |
| US4029672A (en) * | 1976-02-26 | 1977-06-14 | American Hoechst Corporation | Aminoalkylpyrrolobenzoxazalkanes |
| JPS5729817U (enrdf_load_stackoverflow) * | 1980-07-26 | 1982-02-17 | ||
| US4545935A (en) * | 1983-09-12 | 1985-10-08 | Iowa State University Research Foundation, Inc. | Amidoalkylation reactions of anilines |
| DE3525564A1 (de) * | 1985-07-15 | 1987-02-05 | Schering Ag | Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
| ATE114310T1 (de) * | 1988-06-01 | 1994-12-15 | Smithkline Beecham Corp | Alpha-adrenergische rezeptorantagonisten. |
| US5006521A (en) * | 1988-06-01 | 1991-04-09 | Smithkline Beecham Corporation | α-adrenergic receptor antagonists and methods of use thereas |
| US4978660A (en) * | 1988-06-01 | 1990-12-18 | Smithkline Beecham Corporation | α-adrenergic receptor antagonists |
| CA1320953C (en) * | 1988-06-01 | 1993-08-03 | John J. Lafferty | .alpha.-adrenergic receptor antagonists |
| CA1320486C (en) * | 1988-06-01 | 1993-07-20 | John J. Lafferty | .alpha. -adrenergic receptor antagonists |
| US4959360A (en) * | 1988-06-01 | 1990-09-25 | Smithkline Beecham Corporation | α-adrenergic receptor antagonists |
| US4963547A (en) * | 1988-06-01 | 1990-10-16 | Smithkline Beecham Corporation | Alpha-andrenergic receptor antagonists and use thereas |
| EP0344981B1 (en) * | 1988-06-01 | 1994-08-03 | Smithkline Beecham Corporation | Alpha-adrenergic receptor antagonists |
| US4981849A (en) * | 1989-02-23 | 1991-01-01 | Smithkline Beecham Corporation | Alpha-adrenergic receptor antagonists |
| US4981848A (en) * | 1989-02-23 | 1991-01-01 | Smithkline Beecham Corporation | Alpha-adrenergic receptor antagonists |
| US6765004B1 (en) * | 1999-06-17 | 2004-07-20 | Ortho-Mcneil Pharmaceutical, Inc. | Indoloazepines as vasopressin receptor antagonists |
| EP2134714A1 (en) * | 2007-03-13 | 2009-12-23 | Biovitrum AB (publ) | Tricyclic isoquinoline derivatives for treatment of obesity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3182071A (en) * | 1961-06-27 | 1965-05-04 | Warner Lambert Pharmaceutical | Acylated indole derivatives |
-
0
- BE BE795451D patent/BE795451A/xx not_active IP Right Cessation
-
1972
- 1972-02-23 US US00228743A patent/US3833591A/en not_active Expired - Lifetime
-
1973
- 1973-01-26 GB GB423373A patent/GB1418354A/en not_active Expired
- 1973-02-10 DE DE2306605A patent/DE2306605A1/de not_active Ceased
- 1973-02-15 FR FR7305356A patent/FR2181738B1/fr not_active Expired
- 1973-02-16 JP JP1846373A patent/JPS5516434B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2306605A1 (de) | 1973-09-06 |
| FR2181738B1 (enrdf_load_stackoverflow) | 1976-03-05 |
| US3833591A (en) | 1974-09-03 |
| FR2181738A1 (enrdf_load_stackoverflow) | 1973-12-07 |
| JPS5516434B2 (enrdf_load_stackoverflow) | 1980-05-01 |
| JPS4892400A (enrdf_load_stackoverflow) | 1973-11-30 |
| BE795451A (fr) | 1973-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |