GB1418354A - Tricyclicicazaindole hypoglycemic agents - Google Patents

Tricyclicicazaindole hypoglycemic agents

Info

Publication number
GB1418354A
GB1418354A GB423373A GB423373A GB1418354A GB 1418354 A GB1418354 A GB 1418354A GB 423373 A GB423373 A GB 423373A GB 423373 A GB423373 A GB 423373A GB 1418354 A GB1418354 A GB 1418354A
Authority
GB
United Kingdom
Prior art keywords
formula
carbon atoms
compounds
alkyl
hypoglycemic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB423373A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of GB1418354A publication Critical patent/GB1418354A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1418354 Tricyclicazaindole compounds PFIZER Inc 26 Jan 1973 [23 Feb 1972] 4233/73 Heading C2C The invention comprises compounds of the formula and the pharmaceutically acceptable acid addition salts thereof wherein x is -(CH 2 ) n - wherein n is an integer from 1 to 3 or is -OCH 2 -CH 2 -, the terminal methylene group of said radical being attached to the amino function R 1 and R 2 are each hydrogen or methoxy and R 3 is alkyl having from 1 to 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, phenyl alkyl having up to 3 carbon atoms in the alkyl moiety, phenyl, chlorophenyl, tolyl, anisyl or thienyl. Such compounds are prepared by reacting a compound of the formula with an aldehyde of the formula R 3 CHO and if desired preparing the pharmaceutically acceptable acid addition salts. The products are hypoglycemic agents. Examples are furnished.
GB423373A 1972-02-23 1973-01-26 Tricyclicicazaindole hypoglycemic agents Expired GB1418354A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00228743A US3833591A (en) 1972-02-23 1972-02-23 1,3,4,5-tetrahydropyrrolo(4,3,2-d,e)isoquinolines and related compounds

Publications (1)

Publication Number Publication Date
GB1418354A true GB1418354A (en) 1975-12-17

Family

ID=22858420

Family Applications (1)

Application Number Title Priority Date Filing Date
GB423373A Expired GB1418354A (en) 1972-02-23 1973-01-26 Tricyclicicazaindole hypoglycemic agents

Country Status (6)

Country Link
US (1) US3833591A (en)
JP (1) JPS5516434B2 (en)
BE (1) BE795451A (en)
DE (1) DE2306605A1 (en)
FR (1) FR2181738B1 (en)
GB (1) GB1418354A (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3900477A (en) * 1973-11-06 1975-08-19 Ayerst Mckenna & Harrison 5-amino-and 5-hydrazinodihydropyrroloisoquinoline derivatives
US3978066A (en) * 1973-11-06 1976-08-31 Ayerst, Mckenna And Harrison Ltd. Certain 4,6-dihydropyrrolotriazoline-quinoline derivatives
US3950343A (en) * 1973-11-06 1976-04-13 Ayerst, Mckenna And Harrison Ltd. Pyrroloisoquinoline derivatives
US4029672A (en) * 1976-02-26 1977-06-14 American Hoechst Corporation Aminoalkylpyrrolobenzoxazalkanes
JPS5729817U (en) * 1980-07-26 1982-02-17
US4545935A (en) * 1983-09-12 1985-10-08 Iowa State University Research Foundation, Inc. Amidoalkylation reactions of anilines
DE3525564A1 (en) * 1985-07-15 1987-02-05 Schering Ag TRICYCLIC COMPOUNDS WITH INDOLSTRUCTURE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
EP0344980A3 (en) * 1988-06-01 1991-05-15 Smithkline Beecham Corporation Alpha-adrenergic receptor antagonists
US4959360A (en) * 1988-06-01 1990-09-25 Smithkline Beecham Corporation α-adrenergic receptor antagonists
US5006521A (en) * 1988-06-01 1991-04-09 Smithkline Beecham Corporation α-adrenergic receptor antagonists and methods of use thereas
NZ229300A (en) * 1988-06-01 1991-04-26 Smithkline Beckman Corp Substituted-2-ethenyl-3,4,5,6-tetrahydrothieno (4,3,2-cf)(3)benzazepine derivatives and pharmaceutical compositions
US4963547A (en) * 1988-06-01 1990-10-16 Smithkline Beecham Corporation Alpha-andrenergic receptor antagonists and use thereas
US4978660A (en) * 1988-06-01 1990-12-18 Smithkline Beecham Corporation α-adrenergic receptor antagonists
CA1320954C (en) * 1988-06-01 1993-08-03 Smithkline Beckman Corporation .alpha.-adrenergic receptor antagonists
EP0344982B1 (en) * 1988-06-01 1994-11-23 Smithkline Beecham Corporation Alpha-adrenergic receptor antagonists
US4981848A (en) * 1989-02-23 1991-01-01 Smithkline Beecham Corporation Alpha-adrenergic receptor antagonists
US4981849A (en) * 1989-02-23 1991-01-01 Smithkline Beecham Corporation Alpha-adrenergic receptor antagonists
US6765004B1 (en) * 1999-06-17 2004-07-20 Ortho-Mcneil Pharmaceutical, Inc. Indoloazepines as vasopressin receptor antagonists
WO2008110598A1 (en) * 2007-03-13 2008-09-18 Biovitrum Ab (Publ) Tricyclic isoquinoline derivatives for treatment of obesity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives

Also Published As

Publication number Publication date
BE795451A (en) 1973-08-16
JPS4892400A (en) 1973-11-30
FR2181738B1 (en) 1976-03-05
FR2181738A1 (en) 1973-12-07
DE2306605A1 (en) 1973-09-06
US3833591A (en) 1974-09-03
JPS5516434B2 (en) 1980-05-01

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee