GB1414621A - Tricyclic compounds having antiallergic properties and pharmaceuti cal compositions thereof - Google Patents

Tricyclic compounds having antiallergic properties and pharmaceuti cal compositions thereof

Info

Publication number
GB1414621A
GB1414621A GB860872*[A GB860872A GB1414621A GB 1414621 A GB1414621 A GB 1414621A GB 860872 A GB860872 A GB 860872A GB 1414621 A GB1414621 A GB 1414621A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compositions
tricyclic compounds
aug
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB860872*[A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB860872*[A priority Critical patent/GB1414621A/en
Priority to IE1220/72A priority patent/IE37007B1/en
Priority to NL7212174A priority patent/NL7212174A/xx
Priority to IL40320A priority patent/IL40320A/en
Priority to PH13875A priority patent/PH10857A/en
Priority to ES406458A priority patent/ES406458A1/en
Priority to DD165511A priority patent/DD106263A5/xx
Priority to FR7231756A priority patent/FR2154476B1/fr
Priority to AU46406/72A priority patent/AU483094B2/en
Priority to US05/287,042 priority patent/US3959482A/en
Priority to CA151,211A priority patent/CA1026764A/en
Priority to DE2243997A priority patent/DE2243997A1/en
Priority to BE788514D priority patent/BE788514A/en
Priority to AR243958A priority patent/AR209571A1/en
Priority to CH1316472A priority patent/CH630885A5/en
Priority to JP47089979A priority patent/JPS4834865A/ja
Priority to LU66018A priority patent/LU66018A1/xx
Priority to DD179483*A priority patent/DD114946A5/xx
Priority to US05/338,414 priority patent/US3987088A/en
Publication of GB1414621A publication Critical patent/GB1414621A/en
Priority to PH17968A priority patent/PH10945A/en
Priority to FI760877A priority patent/FI760877A/fi
Priority to CA280,042A priority patent/CA1026679A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/647—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
    • C07C49/653—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C66/00—Quinone carboxylic acids
    • C07C66/02—Anthraquinone carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1414621 Antiallergic medicines WELLCOME FOUNDATION LTD 8 Dec 1972 [8 Sept 1971 24 Feb 1972 (3) 29 March 1972 1 Aug 1972 29 Aug 1972 (3)] 41852/71 8608/72 8609/72 8610/72 14909/72 35818/72 39939/72 39940/72 40079/72 Heading A5B [Also in Divisions C2 and C5] Therapeutic compositions having anti-allergic activity comprise (subject to disclaimer) compounds of formula wherein Z<SP>1</SP> is COX, X being OH (or a salt thereof), O-C 1-6 -alkyl or NA 2 (optionally C 1-6 alkyl substituted); Z<SP>3</SP> is a bond, CO, O or NR (where R is H or C 1-4 alkyl); and Z<SP>2</SP> is H, Z<SP>1</SP> or (when Z<SP>3</SP> is a bond or NR) NO 2 , CN, halogen, C 2-7 alkanoyl or C 1-6 alkyl or alkoxy. Oral, rectal, opthalmic, pulmonary, nasal, dermal, topical or parenteral administration may be applied. The compositions may contain other active ingredients, e.g. the bronchodilators isoprenaline, adrenaline, orciprenaline or isoethanine.
GB860872*[A 1971-09-08 1972-02-24 Tricyclic compounds having antiallergic properties and pharmaceuti cal compositions thereof Expired GB1414621A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GB860872*[A GB1414621A (en) 1971-09-08 1972-02-24 Tricyclic compounds having antiallergic properties and pharmaceuti cal compositions thereof
IL40320A IL40320A (en) 1971-09-08 1972-09-07 Tricyclic carbonyl compounds,their preparation and pharmaceutical compositions containing them
DD179483*A DD114946A5 (en) 1971-09-08 1972-09-07
DE2243997A DE2243997A1 (en) 1971-09-08 1972-09-07 TRICYCLIC COMPOUNDS, METHODS OF MANUFACTURING AND USING them
PH13875A PH10857A (en) 1971-09-08 1972-09-07 Compositions and method of treating allergic conditions
ES406458A ES406458A1 (en) 1971-09-08 1972-09-07 Method for preparing an adequate pharmaceutical composition for the use of the treatment of allergic states of mammals. (Machine-translation by Google Translate, not legally binding)
DD165511A DD106263A5 (en) 1971-09-08 1972-09-07
FR7231756A FR2154476B1 (en) 1971-09-08 1972-09-07
AU46406/72A AU483094B2 (en) 1972-09-07 Cyclic carbonyl compounds
US05/287,042 US3959482A (en) 1971-09-08 1972-09-07 Fluorenone carboxylic acids for the prevention of the symptoms of asthma and allergin rhinitis
AR243958A AR209571A1 (en) 1971-09-08 1972-09-07 PROCEDURE FOR PREPARING FLUORENONE-DERIVED COMPOUNDS
IE1220/72A IE37007B1 (en) 1971-09-08 1972-09-07 Tricyclic compounds having antiallergic properties and pharmaceutical compositions thereof
BE788514D BE788514A (en) 1971-09-08 1972-09-07 CYCLIC CARBONYL COMPOUNDS
CA151,211A CA1026764A (en) 1971-09-08 1972-09-07 Fluorenones
CH1316472A CH630885A5 (en) 1971-09-08 1972-09-07 Process for preparing tricyclic compounds, and the use of these compounds.
JP47089979A JPS4834865A (en) 1971-09-08 1972-09-07
LU66018A LU66018A1 (en) 1971-09-08 1972-09-07
NL7212174A NL7212174A (en) 1971-09-08 1972-09-07
US05/338,414 US3987088A (en) 1971-09-08 1973-03-06 Cyclic carbonyl compounds
PH17968A PH10945A (en) 1971-09-08 1976-01-13 Derivatives of fluorenone 2,7-dicarboxylic acid
FI760877A FI760877A (en) 1971-09-08 1976-04-01
CA280,042A CA1026679A (en) 1971-09-08 1977-06-07 Pharmaceutical compositions containing fluorenones and anthraquinone carboxylic acids

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB4185271 1971-09-08
GB860972 1972-02-24
GB860872*[A GB1414621A (en) 1971-09-08 1972-02-24 Tricyclic compounds having antiallergic properties and pharmaceuti cal compositions thereof
GB861072 1972-02-24
GB1490972 1972-03-29
GB3581872 1972-08-01
GB4007972 1972-08-29
GB3994072 1972-08-29
GB3993972 1972-08-29

Publications (1)

Publication Number Publication Date
GB1414621A true GB1414621A (en) 1975-11-19

Family

ID=27576257

Family Applications (1)

Application Number Title Priority Date Filing Date
GB860872*[A Expired GB1414621A (en) 1971-09-08 1972-02-24 Tricyclic compounds having antiallergic properties and pharmaceuti cal compositions thereof

Country Status (1)

Country Link
GB (1) GB1414621A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016509A1 (en) * 1991-03-18 1992-10-01 Sloan-Kettering Institute For Cancer Research Multisubstituted 1-hydroxy-9-acridones with anticancer activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016509A1 (en) * 1991-03-18 1992-10-01 Sloan-Kettering Institute For Cancer Research Multisubstituted 1-hydroxy-9-acridones with anticancer activity
US5296602A (en) * 1991-03-18 1994-03-22 Sloan-Kettering Institute For Cancer Research Multisubstituted 1-hydroxy-9-acridones with anticancer activity

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee