GB1414223A - Trifluoromethylated phenyl aminopropane compounds - Google Patents
Trifluoromethylated phenyl aminopropane compoundsInfo
- Publication number
- GB1414223A GB1414223A GB924173A GB924173A GB1414223A GB 1414223 A GB1414223 A GB 1414223A GB 924173 A GB924173 A GB 924173A GB 924173 A GB924173 A GB 924173A GB 1414223 A GB1414223 A GB 1414223A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lower alkyl
- amino
- piperazino
- alkyl
- piperidino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1414223 Trifluoromethylphenylamino propane derivatives DELMAR CHEMICALS Ltd 26 Feb 1974 [26 Feb 1973] 9241/73 Heading C2C Novel compounds of Formula II wherein R is H or C 1-6 alkyl, Alk is C 1-6 alkylene and X is an unsubstituted amino-(-NH 2 ); (lower alkyl)-amino: di-(lower alkyl)-amino; (lower alkenyl)-amino; di-(lower alkenyl)-amino; phenylamino; (hydroxy-lower alkyl)-amino; di- (hydroxy lower-alkyl)-amino; (amino-lower alkyl)-amino; di-(amino-lower alkyl)-amino; heterocyclic groups of less than 12 carbon atoms as exemplified by piperidino; (lower alkyl)- piperidino, e.g. 2-, 3-, or 4-(lower alkyl)-piperidino; di-(lower alkyl)-piperidino; (lower alkoxy)- piperidino; pyrrolidino; (lower alkyl)-pyrrolidino; di-(lower alkyl)-pyrrolidino; (lower alkoxy)-pyrrolidino; morpholino; (lower alkyl)- morpholino; di-(lower alkyl)-morpholino; (lower alkoxy)-morpholino; thiomorpholino; (lower alkyl)-thiomorpholino; di-(lower alkyl)- thiomorpholino; piperazino; (lower alkyl)-piperazino; (e.g. C or N-methyl piperazino); di-C- (lower alkyl)-piperazino; (lower alkoxy)-piperazino and (lower carbalkoxy)-piperazino and R 3 -(lower alkyl)-amino wherein R 3 is a 5- or 6-membered heterocyolic ring containing nitrogen, oxygen or sulphur and up to 2 ethylenic double bonds (lower denotes groups of up to 6 carbon atoms) are prepared by one of the following methods: (a) a compound of Formula III is reduced; (b) a compound of Formula VI wherein Y is halogen is reacted with an amine NH 2 AlkX; (c) reductive amination of a compound of Formula IV or (d) reduction of the oxime of IV above and reaction with Y-Alk-X. Pharmaceutical compositions in conventional forms for oral or rectal administration having anorexigenic activity comprise an above novel compound and a carrier or diluent.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB924173A GB1414223A (en) | 1973-02-26 | 1973-02-26 | Trifluoromethylated phenyl aminopropane compounds |
| CA193,534A CA1041505A (en) | 1973-02-26 | 1974-02-26 | Trifluoromethylated-phenyl-aminopropane compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB924173A GB1414223A (en) | 1973-02-26 | 1973-02-26 | Trifluoromethylated phenyl aminopropane compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1414223A true GB1414223A (en) | 1975-11-19 |
Family
ID=9868149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB924173A Expired GB1414223A (en) | 1973-02-26 | 1973-02-26 | Trifluoromethylated phenyl aminopropane compounds |
Country Status (2)
| Country | Link |
|---|---|
| CA (1) | CA1041505A (en) |
| GB (1) | GB1414223A (en) |
-
1973
- 1973-02-26 GB GB924173A patent/GB1414223A/en not_active Expired
-
1974
- 1974-02-26 CA CA193,534A patent/CA1041505A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1041505A (en) | 1978-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1527297A (en) | Pyrazine carboxamides | |
| IE37699B1 (en) | Novel pleuromutilins | |
| GB1425505A (en) | 5-substituted 2-amino-4-arylthiazoles and their preparation | |
| GB1456175A (en) | Therapeutic urea derivatives | |
| GB1239029A (en) | ||
| GB1098140A (en) | 2-amino-halogenobenzylamines | |
| GB1455605A (en) | Bis-triazinyl-aminostilbene derivatives | |
| ES400963A1 (en) | 3-benzylpyridines | |
| GB1528343A (en) | Erythromycin derivatives | |
| GB1414223A (en) | Trifluoromethylated phenyl aminopropane compounds | |
| GB1436533A (en) | Aryl piperazine derivatives of adenine | |
| GB1195932A (en) | Quinazolinylureas | |
| GB1448781A (en) | N- omega-amino- alkylaniline compounds | |
| GB1437896A (en) | Substituted thiazole-2-carboxylic amides and process for the preparation thereof | |
| GB1449802A (en) | Piperazine derivatives and compositions containing them for treating parkinsons disease | |
| GB1087174A (en) | Piperidine derivatives | |
| GB1464242A (en) | Benzoyl benzofurans and compositions comprising them | |
| GB1304069A (en) | ||
| GB1428626A (en) | Trisubstituted 1,2,4-triazoles | |
| GB1417355A (en) | Substituted piperazine and homopiperazine derivatives | |
| GB1156781A (en) | New Heterocyclic Compounds | |
| GB1526038A (en) | 5-thiazole methane amine derivatives and salts thereof processes for preparing them and pharmaceutical compositions containing them | |
| GB1120186A (en) | Cyclohexene amino acid derivatives and process for their preparation | |
| GB1108578A (en) | 5-aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles | |
| GB1281433A (en) | Allene polymines and manufacture thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |