GB1406611A - Pharmaceutically active secondary phosphoric acid esters - Google Patents
Pharmaceutically active secondary phosphoric acid estersInfo
- Publication number
- GB1406611A GB1406611A GB450872*[A GB450872A GB1406611A GB 1406611 A GB1406611 A GB 1406611A GB 450872 A GB450872 A GB 450872A GB 1406611 A GB1406611 A GB 1406611A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkoxy
- substituents
- formula
- cyclopentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003014 phosphoric acid esters Chemical group 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 150000003180 prostaglandins Chemical class 0.000 abstract 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 2
- -1 4-biphenylyl Chemical group 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 229940064004 antiseptic throat preparations Drugs 0.000 abstract 1
- 150000001767 cationic compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002892 organic cations Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
- C07F9/1406—Esters of phosphoric acids containing P(=O)-halide groups containing the structure Hal-P(=O)-O-aryl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/242—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyaryl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB450872*[A GB1406611A (en) | 1971-08-17 | 1972-01-31 | Pharmaceutically active secondary phosphoric acid esters |
| US00280276A US3851019A (en) | 1971-08-17 | 1972-08-14 | Secondary phosphoric acid esters and salts thereof |
| CA149,556A CA999873A (en) | 1971-08-17 | 1972-08-16 | Secondary phosphoric acid ester |
| CH1216872A CH606043A5 (en) | 1971-08-17 | 1972-08-16 | Sec phosphoric acid esters |
| FR7229457A FR2150791B1 (enrdf_load_stackoverflow) | 1971-08-17 | 1972-08-17 | |
| NL7211262A NL7211262A (enrdf_load_stackoverflow) | 1971-08-17 | 1972-08-17 | |
| JP47082426A JPS5930718B2 (ja) | 1971-08-17 | 1972-08-17 | 新規リン酸エステル化合物の製造法 |
| BE787665A BE787665A (fr) | 1971-08-17 | 1972-08-17 | Nouveaux esters secondaires de l'acide phosphorique, sels de tels esters, et procede pour leur preparation |
| US05/519,542 US3995033A (en) | 1971-08-17 | 1974-10-31 | Secondary phosphoric acid esters, composition and method of use |
| AT2076A AT351563B (de) | 1972-01-31 | 1976-01-02 | Verfahren zur herstellung von neuen sekundaeren phosphorsaeureestern und ihren salzen |
| US05/716,197 US4049800A (en) | 1971-08-17 | 1976-08-20 | Method, composition and compounds for treating excess prostaglandins |
| US05/716,198 US4049799A (en) | 1971-08-17 | 1976-08-20 | Method, composition and compounds for treating excess prostaglandins |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3857971 | 1971-08-17 | ||
| GB3858071 | 1971-08-17 | ||
| GB3857871 | 1971-08-17 | ||
| GB3857771A GB1349882A (en) | 1970-01-05 | 1971-08-17 | Cutting probe tip suitable for eye surgery |
| GB450872*[A GB1406611A (en) | 1971-08-17 | 1972-01-31 | Pharmaceutically active secondary phosphoric acid esters |
| GB450972 | 1972-01-31 | ||
| GB451072 | 1972-01-31 | ||
| GB451172 | 1972-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1406611A true GB1406611A (en) | 1975-09-17 |
Family
ID=27571125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB450872*[A Expired GB1406611A (en) | 1971-08-17 | 1972-01-31 | Pharmaceutically active secondary phosphoric acid esters |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5930718B2 (enrdf_load_stackoverflow) |
| BE (1) | BE787665A (enrdf_load_stackoverflow) |
| FR (1) | FR2150791B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1406611A (enrdf_load_stackoverflow) |
| NL (1) | NL7211262A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000043402A3 (en) * | 1999-01-21 | 2000-11-30 | Univ Texas | Inhibitors of intestinal apical membrane na/phosphate co-transportation |
| US9487663B2 (en) | 2010-03-30 | 2016-11-08 | Surmodics, Inc. | Photoactivatable crosslinker |
| US10315987B2 (en) | 2010-12-13 | 2019-06-11 | Surmodics, Inc. | Photo-crosslinker |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3937823A (en) | 1974-10-18 | 1976-02-10 | Nelson Research & Development Co. | Topical anti-inflammatory compositions and methods of use |
| US4859736A (en) * | 1987-03-30 | 1989-08-22 | Ciba-Geigy Corporation | Synthetic polystyrene resin and its use in solid phase peptide synthesis |
-
1972
- 1972-01-31 GB GB450872*[A patent/GB1406611A/en not_active Expired
- 1972-08-17 JP JP47082426A patent/JPS5930718B2/ja not_active Expired
- 1972-08-17 BE BE787665A patent/BE787665A/xx unknown
- 1972-08-17 NL NL7211262A patent/NL7211262A/xx not_active Application Discontinuation
- 1972-08-17 FR FR7229457A patent/FR2150791B1/fr not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000043402A3 (en) * | 1999-01-21 | 2000-11-30 | Univ Texas | Inhibitors of intestinal apical membrane na/phosphate co-transportation |
| US6355823B1 (en) | 1999-01-21 | 2002-03-12 | Board Of Regents, The University Of Texas System | Inhibitors of intestinal apical membrane na/phoshate co-transportation |
| US6787528B2 (en) | 1999-01-21 | 2004-09-07 | Board Of Regents, The University Of Texas System | Inhibitors of intestinal apical membrane Na/phosphate co-transportation |
| US9487663B2 (en) | 2010-03-30 | 2016-11-08 | Surmodics, Inc. | Photoactivatable crosslinker |
| US9994721B2 (en) | 2010-03-30 | 2018-06-12 | Surmodics, Inc. | Photoactivatable crosslinker |
| US10253193B2 (en) | 2010-03-30 | 2019-04-09 | Surmodics, Inc. | Photoactivatable crosslinker |
| US10745573B2 (en) | 2010-03-30 | 2020-08-18 | Surmodics, Inc. | Photoactivatable crosslinker |
| US10315987B2 (en) | 2010-12-13 | 2019-06-11 | Surmodics, Inc. | Photo-crosslinker |
| US10941112B2 (en) | 2010-12-13 | 2021-03-09 | Surmodics, Inc. | Photo-crosslinker |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5930718B2 (ja) | 1984-07-28 |
| BE787665A (fr) | 1972-12-18 |
| FR2150791A1 (enrdf_load_stackoverflow) | 1973-04-13 |
| JPS4829746A (enrdf_load_stackoverflow) | 1973-04-19 |
| NL7211262A (enrdf_load_stackoverflow) | 1973-02-20 |
| FR2150791B1 (enrdf_load_stackoverflow) | 1975-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |