GB1404003A - N-substituted-4-amidopiperidines tetrahydropyridines and pyridines - Google Patents

N-substituted-4-amidopiperidines tetrahydropyridines and pyridines

Info

Publication number
GB1404003A
GB1404003A GB272072A GB272072A GB1404003A GB 1404003 A GB1404003 A GB 1404003A GB 272072 A GB272072 A GB 272072A GB 272072 A GB272072 A GB 272072A GB 1404003 A GB1404003 A GB 1404003A
Authority
GB
United Kingdom
Prior art keywords
amidopiperidines
tetrahydropyridines
pyridines
substituted
amidopiperidines tetrahydropyridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB272072A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE794333D priority Critical patent/BE794333A/xx
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB272072A priority patent/GB1404003A/en
Priority to CA160,793A priority patent/CA984843A/en
Priority to CH82873A priority patent/CH590840A5/xx
Priority to CH1392476A priority patent/CH595347A5/xx
Priority to JP845573A priority patent/JPS59507B2/ja
Priority to FR7302013A priority patent/FR2181678B1/fr
Priority to NL7300838A priority patent/NL180749C/xx
Priority to DE19732302717 priority patent/DE2302717A1/de
Publication of GB1404003A publication Critical patent/GB1404003A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB272072A 1972-01-20 1972-01-20 N-substituted-4-amidopiperidines tetrahydropyridines and pyridines Expired GB1404003A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BE794333D BE794333A (fr) 1972-01-20 Composes heterocycliques azotes therapeutiques
GB272072A GB1404003A (en) 1972-01-20 1972-01-20 N-substituted-4-amidopiperidines tetrahydropyridines and pyridines
CA160,793A CA984843A (en) 1972-01-20 1973-01-09 Heterocyclic compounds
CH82873A CH590840A5 (enExample) 1972-01-20 1973-01-19
CH1392476A CH595347A5 (enExample) 1972-01-20 1973-01-19
JP845573A JPS59507B2 (ja) 1972-01-20 1973-01-19 新規な複素環式化合物の製造方法
FR7302013A FR2181678B1 (enExample) 1972-01-20 1973-01-19
NL7300838A NL180749C (nl) 1972-01-20 1973-01-19 Werkwijze ter bereiding van een farmaceutisch preparaat met antihistaminewerking en werking op het cardiovasculaire systeem, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte piperidinederivaten.
DE19732302717 DE2302717A1 (de) 1972-01-20 1973-01-19 Heterocyclische verbindungen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB272072A GB1404003A (en) 1972-01-20 1972-01-20 N-substituted-4-amidopiperidines tetrahydropyridines and pyridines

Publications (1)

Publication Number Publication Date
GB1404003A true GB1404003A (en) 1975-08-28

Family

ID=9744619

Family Applications (1)

Application Number Title Priority Date Filing Date
GB272072A Expired GB1404003A (en) 1972-01-20 1972-01-20 N-substituted-4-amidopiperidines tetrahydropyridines and pyridines

Country Status (8)

Country Link
JP (1) JPS59507B2 (enExample)
BE (1) BE794333A (enExample)
CA (1) CA984843A (enExample)
CH (2) CH590840A5 (enExample)
DE (1) DE2302717A1 (enExample)
FR (1) FR2181678B1 (enExample)
GB (1) GB1404003A (enExample)
NL (1) NL180749C (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5363385A (en) * 1976-11-12 1978-06-06 Boehringer Mannheim Gmbh Novel aminopropanole derivative process for preparing same and medicine having vasodilating and betaaacceptor interupiing efect
US4235915A (en) 1976-12-11 1980-11-25 John Wyeth & Brother Limited βAdrenergic blocking piperidino ureas and thioureas
US4246268A (en) * 1979-02-09 1981-01-20 Richardson-Merrell Inc. Neuroleptic-4-(naphthylmethyl)piperidine derivatives
US4329348A (en) 1979-02-26 1982-05-11 Ciba-Geigy Corporation N-Oxacyclic-alkylpiperidines as psychostimulants
US4359468A (en) * 1981-02-25 1982-11-16 Boehringer Ingelheim Ltd. Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
US4382943A (en) * 1980-07-04 1983-05-10 Boehringer Mannheim Gmbh Anti-allergic aryl ether derivatives
US4410528A (en) * 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
US4432984A (en) * 1980-03-27 1984-02-21 Emile Bouchara Anti-hypertensive benzodioxan derivatives
US4446141A (en) * 1978-06-02 1984-05-01 Nobuhiro Nakamizo Hypotensive piperidine derivatives

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1542137A (en) * 1976-03-12 1979-03-14 Wyeth John & Brother Ltd Process for preparing 3(piperidinoalkyl)indoles
US4242347A (en) 1979-06-18 1980-12-30 Ciba-Geigy Corporation Hypotensive indolylalkylpiperidyl guanidines and isoureas
EP0025111B1 (en) * 1979-08-10 1984-07-25 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
IL151164A0 (en) 2000-03-06 2003-04-10 Acadia Pharm Inc Azacyclic compounds for use in the treatment of serotonin related diseases
DE60236206D1 (de) 2001-12-28 2010-06-10 Acadia Pharm Inc Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
MXPA04012893A (es) 2002-06-24 2005-03-31 Acadia Pharm Inc Derivados de piperidina n-substituidos como agentes receptores de serotonina.
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
ATE407117T1 (de) 2003-01-16 2008-09-15 Acadia Pharm Inc Selektive serotonin 2a/2c inverse rezeptoragonisten als therapeutika für neurodegenerative erkrankungen
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
US7868176B2 (en) 2004-09-27 2011-01-11 Acadia Pharmaceuticals, Inc. Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-y1)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
EP2134330B1 (en) 2007-03-19 2013-05-08 Acadia Pharmaceuticals Inc. Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
EP3325444B1 (en) 2015-07-20 2021-07-07 Acadia Pharmaceuticals Inc. Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
US11464768B2 (en) 2016-12-20 2022-10-11 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
US20210077479A1 (en) 2017-08-30 2021-03-18 Acadia Pharmaceuticals Inc. Formulations of pimavanserin

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5363385A (en) * 1976-11-12 1978-06-06 Boehringer Mannheim Gmbh Novel aminopropanole derivative process for preparing same and medicine having vasodilating and betaaacceptor interupiing efect
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
US4235915A (en) 1976-12-11 1980-11-25 John Wyeth & Brother Limited βAdrenergic blocking piperidino ureas and thioureas
US4446141A (en) * 1978-06-02 1984-05-01 Nobuhiro Nakamizo Hypotensive piperidine derivatives
US4246268A (en) * 1979-02-09 1981-01-20 Richardson-Merrell Inc. Neuroleptic-4-(naphthylmethyl)piperidine derivatives
US4329348A (en) 1979-02-26 1982-05-11 Ciba-Geigy Corporation N-Oxacyclic-alkylpiperidines as psychostimulants
US4432984A (en) * 1980-03-27 1984-02-21 Emile Bouchara Anti-hypertensive benzodioxan derivatives
US4410528A (en) * 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
US4382943A (en) * 1980-07-04 1983-05-10 Boehringer Mannheim Gmbh Anti-allergic aryl ether derivatives
US4359468A (en) * 1981-02-25 1982-11-16 Boehringer Ingelheim Ltd. Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones

Also Published As

Publication number Publication date
JPS59507B2 (ja) 1984-01-07
DE2302717A1 (de) 1973-07-26
FR2181678A1 (enExample) 1973-12-07
CH595347A5 (enExample) 1978-02-15
BE794333A (fr) 1973-07-19
NL7300838A (enExample) 1973-07-24
NL180749C (nl) 1987-04-16
JPS4880569A (enExample) 1973-10-29
FR2181678B1 (enExample) 1976-09-03
NL180749B (nl) 1986-11-17
CA984843A (en) 1976-03-02
CH590840A5 (enExample) 1977-08-31

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee