GB1395261A - Method for producing a polypeptide having growth-promoting activity and synthetic polypeptides produced by this process - Google Patents
Method for producing a polypeptide having growth-promoting activity and synthetic polypeptides produced by this processInfo
- Publication number
- GB1395261A GB1395261A GB1954272A GB1954272A GB1395261A GB 1395261 A GB1395261 A GB 1395261A GB 1954272 A GB1954272 A GB 1954272A GB 1954272 A GB1954272 A GB 1954272A GB 1395261 A GB1395261 A GB 1395261A
- Authority
- GB
- United Kingdom
- Prior art keywords
- polypeptide
- residues
- per
- polypeptide chain
- tetranitromethane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 14
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 14
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 14
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- NYTOUQBROMCLBJ-UHFFFAOYSA-N Tetranitromethane Chemical compound [O-][N+](=O)C([N+]([O-])=O)([N+]([O-])=O)[N+]([O-])=O NYTOUQBROMCLBJ-UHFFFAOYSA-N 0.000 abstract 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 3
- -1 sulphhydryl groups Chemical group 0.000 abstract 3
- NTNKNFHIAFDCSJ-UHFFFAOYSA-N (2-nitrophenyl) thiohypochlorite Chemical compound [O-][N+](=O)C1=CC=CC=C1SCl NTNKNFHIAFDCSJ-UHFFFAOYSA-N 0.000 abstract 2
- KFDPCYZHENQOBV-UHFFFAOYSA-N 2-(bromomethyl)-4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1CBr KFDPCYZHENQOBV-UHFFFAOYSA-N 0.000 abstract 2
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00137811A US3853832A (en) | 1971-04-27 | 1971-04-27 | Synthetic human pituitary growth hormone and method of producing it |
| US00162946A US3853833A (en) | 1971-04-27 | 1971-07-15 | Synthetic human growth-promoting and lactogenic hormones and method of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1395261A true GB1395261A (en) | 1975-05-21 |
Family
ID=26835604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1954272A Expired GB1395261A (en) | 1971-04-27 | 1972-04-27 | Method for producing a polypeptide having growth-promoting activity and synthetic polypeptides produced by this process |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3853833A (en:Method) |
| CA (1) | CA1002516A (en:Method) |
| CH (3) | CH557331A (en:Method) |
| DE (1) | DE2220746A1 (en:Method) |
| FR (1) | FR2134632B1 (en:Method) |
| GB (1) | GB1395261A (en:Method) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2116980A (en) * | 1982-03-22 | 1983-10-05 | Genentech Inc | Human growth hormone variants |
| US4665160A (en) * | 1982-03-22 | 1987-05-12 | Genentech, Inc. | Novel human growth hormone like protein HGH-V encoded in the human genome |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4952395A (en) * | 1987-02-26 | 1990-08-28 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
| US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| US5688666A (en) * | 1988-10-28 | 1997-11-18 | Genentech, Inc. | Growth hormone variants with altered binding properties |
| US5693498A (en) * | 1989-05-19 | 1997-12-02 | The Board Of Regents Of The University Of Nebraska | DNA encoding a plerocerciod growth factor |
| IE912345A1 (en) * | 1990-08-03 | 1992-02-12 | Pharmacia Ab | Treatment of human lactation failure |
| ES2113940T3 (es) * | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
| US5910483A (en) * | 1991-12-03 | 1999-06-08 | The Board Of Regents Of The University Of Nebraska | Plerocercoid growth factor protein purified from Spirometra mansonoides |
| US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| ES2190388T3 (es) * | 1995-09-21 | 2006-04-01 | Genentech, Inc. | Variantes de la hormona de crecimiento humana. |
| US6645485B2 (en) * | 2000-05-10 | 2003-11-11 | Allan R. Dunn | Method of treating inflammation in the joints of a body |
| WO2005052567A1 (en) * | 2003-11-24 | 2005-06-09 | Biogen Idec Ma Inc. | Methods for detecting half-antibodies using chip-based gel electrophoresis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3264186A (en) * | 1964-02-26 | 1966-08-02 | Upjohn Co | Process for the purification of growth hormone |
-
1971
- 1971-07-15 US US00162946A patent/US3853833A/en not_active Expired - Lifetime
-
1972
- 1972-04-27 CH CH630872A patent/CH557331A/fr not_active IP Right Cessation
- 1972-04-27 CA CA140,738A patent/CA1002516A/en not_active Expired
- 1972-04-27 CH CH852773A patent/CH551379A/fr not_active IP Right Cessation
- 1972-04-27 DE DE19722220746 patent/DE2220746A1/de active Pending
- 1972-04-27 FR FR7215136A patent/FR2134632B1/fr not_active Expired
- 1972-04-27 CH CH852873A patent/CH561689A5/xx not_active IP Right Cessation
- 1972-04-27 GB GB1954272A patent/GB1395261A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2116980A (en) * | 1982-03-22 | 1983-10-05 | Genentech Inc | Human growth hormone variants |
| US4665160A (en) * | 1982-03-22 | 1987-05-12 | Genentech, Inc. | Novel human growth hormone like protein HGH-V encoded in the human genome |
Also Published As
| Publication number | Publication date |
|---|---|
| CH551379A (fr) | 1974-07-15 |
| CH561689A5 (en:Method) | 1975-05-15 |
| FR2134632B1 (en:Method) | 1976-09-17 |
| FR2134632A1 (en:Method) | 1972-12-08 |
| CA1002516A (en) | 1976-12-28 |
| CH557331A (fr) | 1974-12-31 |
| DE2220746A1 (de) | 1972-11-09 |
| US3853833A (en) | 1974-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |