GB1390542A - Anti-inflammatory compositions - Google Patents
Anti-inflammatory compositionsInfo
- Publication number
- GB1390542A GB1390542A GB1638672A GB1638672A GB1390542A GB 1390542 A GB1390542 A GB 1390542A GB 1638672 A GB1638672 A GB 1638672A GB 1638672 A GB1638672 A GB 1638672A GB 1390542 A GB1390542 A GB 1390542A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cellulose
- poly
- amino
- anhydride
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 229920002678 cellulose Polymers 0.000 abstract 7
- 239000001913 cellulose Substances 0.000 abstract 7
- 239000004365 Protease Substances 0.000 abstract 6
- 108091005804 Peptidases Proteins 0.000 abstract 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 4
- -1 p-amino benzyl Chemical group 0.000 abstract 4
- 235000019419 proteases Nutrition 0.000 abstract 4
- 229920002307 Dextran Polymers 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 2
- 229920001308 poly(aminoacid) Polymers 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- JVIPLYCGEZUBIO-UHFFFAOYSA-N 2-(4-fluorophenyl)-1,3-dioxoisoindole-5-carboxylic acid Chemical compound O=C1C2=CC(C(=O)O)=CC=C2C(=O)N1C1=CC=C(F)C=C1 JVIPLYCGEZUBIO-UHFFFAOYSA-N 0.000 abstract 1
- 241000981399 Aspergillus melleus Species 0.000 abstract 1
- 240000006439 Aspergillus oryzae Species 0.000 abstract 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 abstract 1
- 244000063299 Bacillus subtilis Species 0.000 abstract 1
- 235000014469 Bacillus subtilis Nutrition 0.000 abstract 1
- 108010004032 Bromelains Proteins 0.000 abstract 1
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- 229920001425 Diethylaminoethyl cellulose Polymers 0.000 abstract 1
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 235000019454 L-leucine Nutrition 0.000 abstract 1
- 239000004395 L-leucine Substances 0.000 abstract 1
- 241000235395 Mucor Species 0.000 abstract 1
- 108010019160 Pancreatin Proteins 0.000 abstract 1
- 108090000526 Papain Proteins 0.000 abstract 1
- 241000228150 Penicillium chrysogenum Species 0.000 abstract 1
- 108090000284 Pepsin A Proteins 0.000 abstract 1
- 102000057297 Pepsin A Human genes 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 241000235528 Rhizopus microsporus var. chinensis Species 0.000 abstract 1
- 241000187392 Streptomyces griseus Species 0.000 abstract 1
- 241000042002 Trametes sanguinea Species 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- MSSASWHZWBYIIG-HOTGVXAUSA-N [(2S)-1-[(2S)-2-(carboxyamino)-3-(4-hydroxyphenyl)propanoyl]oxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamic acid Chemical compound C([C@H](NC(=O)O)C(=O)OC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(O)=O)C1=CC=C(O)C=C1 MSSASWHZWBYIIG-HOTGVXAUSA-N 0.000 abstract 1
- BESYJTGVSRKLNB-BKLSDQPFSA-N [(3s)-5-methyl-2,6-dioxooxan-3-yl]carbamic acid Chemical compound CC1C[C@H](NC(O)=O)C(=O)OC1=O BESYJTGVSRKLNB-BKLSDQPFSA-N 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 abstract 1
- 229960003136 leucine Drugs 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 229940055695 pancreatin Drugs 0.000 abstract 1
- 235000019834 papain Nutrition 0.000 abstract 1
- 229940055729 papain Drugs 0.000 abstract 1
- 229940111202 pepsin Drugs 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
- 229960001322 trypsin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2400571A JPS5443074B1 (enrdf_load_stackoverflow) | 1971-04-14 | 1971-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1390542A true GB1390542A (en) | 1975-04-16 |
Family
ID=12126433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1638672A Expired GB1390542A (en) | 1971-04-14 | 1972-04-10 | Anti-inflammatory compositions |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS5443074B1 (enrdf_load_stackoverflow) |
DE (1) | DE2218162A1 (enrdf_load_stackoverflow) |
GB (1) | GB1390542A (enrdf_load_stackoverflow) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0045285A1 (en) * | 1980-07-01 | 1982-02-03 | Etablissement TEXCONTOR | Non absorbable compounds of mucolytic activity, the process for their preparation and therapeutic compositions which contain them as active principle |
GB2240040A (en) * | 1990-01-04 | 1991-07-24 | Vnii Textil Galanterey Promy | Immobilised enzyme-containing wound dressings |
WO2003027154A1 (en) * | 2001-09-26 | 2003-04-03 | Smith & Nephew Plc | Polymers with structure-defined functions |
WO2004100981A1 (de) * | 2003-05-14 | 2004-11-25 | Mucos Pharma Gmbh & Co. | Enzymhaltige zusammensetzungen, daraus hergestellte diätetische lebensmittel und arzneimittel und ihre verwendung für medizinische zwecke |
US7998476B2 (en) | 2006-11-22 | 2011-08-16 | Standard Biologics, Inc. | Method of treatment using Aspergillus oryzae protease |
US8956624B2 (en) | 2007-12-19 | 2015-02-17 | Elc Management, Llc | Compositions and methods for treating skin with extract from Trametes |
US9771570B2 (en) | 2012-09-05 | 2017-09-26 | Novozymes A/S | Polypeptides having protease activity |
CN114224980A (zh) * | 2020-09-08 | 2022-03-25 | 上海市同仁医院 | 一种外用涂抹组合物 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4120971A (en) | 1977-03-01 | 1978-10-17 | Merck & Co., Inc. | Novel N-carboxy-alpha-amino acid anhydrides |
JPS58189122A (ja) * | 1982-04-30 | 1983-11-04 | Kaken Pharmaceut Co Ltd | 高脂血症予防治療剤 |
-
1971
- 1971-04-14 JP JP2400571A patent/JPS5443074B1/ja active Pending
-
1972
- 1972-04-10 GB GB1638672A patent/GB1390542A/en not_active Expired
- 1972-04-14 DE DE19722218162 patent/DE2218162A1/de active Pending
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0045285A1 (en) * | 1980-07-01 | 1982-02-03 | Etablissement TEXCONTOR | Non absorbable compounds of mucolytic activity, the process for their preparation and therapeutic compositions which contain them as active principle |
US4409138A (en) | 1980-07-01 | 1983-10-11 | Etablissement Texcontor | Non-absorbable compounds of mucolytic activity, the process for their preparation, and therapeutic compositions which contain them as active principle |
US4559322A (en) * | 1980-07-01 | 1985-12-17 | Etablissement Texcontor | Non-absorbable compounds of mucolytic activity, the process for their preparation, and therapeutic compositions which contain them as active principle |
GB2240040A (en) * | 1990-01-04 | 1991-07-24 | Vnii Textil Galanterey Promy | Immobilised enzyme-containing wound dressings |
AU2002329421B2 (en) * | 2001-09-26 | 2008-09-25 | Smith & Nephew Plc | Polymers with structure-defined functions |
WO2003027154A1 (en) * | 2001-09-26 | 2003-04-03 | Smith & Nephew Plc | Polymers with structure-defined functions |
US7955594B2 (en) * | 2001-09-26 | 2011-06-07 | Smith & Nephew, Plc | Polymers with structure-defined functions |
WO2004100981A1 (de) * | 2003-05-14 | 2004-11-25 | Mucos Pharma Gmbh & Co. | Enzymhaltige zusammensetzungen, daraus hergestellte diätetische lebensmittel und arzneimittel und ihre verwendung für medizinische zwecke |
US7998476B2 (en) | 2006-11-22 | 2011-08-16 | Standard Biologics, Inc. | Method of treatment using Aspergillus oryzae protease |
US8956624B2 (en) | 2007-12-19 | 2015-02-17 | Elc Management, Llc | Compositions and methods for treating skin with extract from Trametes |
US9771570B2 (en) | 2012-09-05 | 2017-09-26 | Novozymes A/S | Polypeptides having protease activity |
US10006017B2 (en) | 2012-09-05 | 2018-06-26 | Novozymes A/S | Animal feed additives comprising a protease and methods of using |
US10563188B2 (en) | 2012-09-05 | 2020-02-18 | Novozymes A/S | Polypeptides having protease activity |
CN114224980A (zh) * | 2020-09-08 | 2022-03-25 | 上海市同仁医院 | 一种外用涂抹组合物 |
Also Published As
Publication number | Publication date |
---|---|
DE2218162A1 (de) | 1972-11-02 |
JPS5443074B1 (enrdf_load_stackoverflow) | 1979-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |