GB1388265A - Preparation of antibiotic compounds - Google Patents

Preparation of antibiotic compounds

Info

Publication number
GB1388265A
GB1388265A GB670871A GB670871A GB1388265A GB 1388265 A GB1388265 A GB 1388265A GB 670871 A GB670871 A GB 670871A GB 670871 A GB670871 A GB 670871A GB 1388265 A GB1388265 A GB 1388265A
Authority
GB
United Kingdom
Prior art keywords
iminoether
carboxylic acid
chloro
chlorides
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB670871A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB670871A priority Critical patent/GB1388265A/en
Priority to JP2405672A priority patent/JPS5421358B1/ja
Priority to NL7203191A priority patent/NL7203191A/xx
Priority to HUGA001081 priority patent/HU163268B/hu
Priority to PL15399072A priority patent/PL90110B1/pl
Priority to IE31672A priority patent/IE36155B1/en
Priority to CH359172A priority patent/CH571006A5/xx
Priority to AT205272A priority patent/AT332537B/en
Priority to CA136,780A priority patent/CA1002036A/en
Priority to BE780510A priority patent/BE780510A/xx
Priority to DK110972A priority patent/DK137190B/en
Priority to AU39848/72A priority patent/AU470876B2/en
Priority to DE19722211763 priority patent/DE2211763C2/en
Priority to ES400637A priority patent/ES400637A1/en
Priority to CS162272A priority patent/CS193013B2/en
Priority to FR7208369A priority patent/FR2129579A5/fr
Publication of GB1388265A publication Critical patent/GB1388265A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

1388265 6-Amino penicillanic acid GLAXO LABORATORIES Ltd 25 Feb 1972 [12 March 1971] 6708/71 Heading C2C In a process for the diacylation of a penicillin the 3-carboxyl group of a 6#-acylamino-2,2- dimethylpenam-3α-carboxylic acid is protected by forming a mixed anhydride with another carboxylic acid, especially acetyl, propionyl chloro- and di-chloro-acetyl chlorides, ethyl- and methyl-oxalyl chlorides, the protected compound is converted into the iminohalide then into the iminoether and finally hydrolysed with water under acidic conditions. Anhydride, imino halide and iminoether formation is carried out under standard conditions.
GB670871A 1971-03-12 1971-03-12 Preparation of antibiotic compounds Expired GB1388265A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB670871A GB1388265A (en) 1971-03-12 1971-03-12 Preparation of antibiotic compounds
JP2405672A JPS5421358B1 (en) 1971-03-12 1972-03-10
NL7203191A NL7203191A (en) 1971-03-12 1972-03-10
HUGA001081 HU163268B (en) 1971-03-12 1972-03-10
PL15399072A PL90110B1 (en) 1971-03-12 1972-03-10
IE31672A IE36155B1 (en) 1971-03-12 1972-03-10 Preparation of 6-amino-penicillanic acid
CH359172A CH571006A5 (en) 1971-03-12 1972-03-10
AT205272A AT332537B (en) 1971-03-12 1972-03-10 METHOD FOR PRODUCING 6BETA-AMINO-2,2-DIMETHYLPENAM-3ALFA-CARBONIC ACID
CA136,780A CA1002036A (en) 1971-03-12 1972-03-10 Preparation of 6-aminopenicillanic acid
BE780510A BE780510A (en) 1971-03-12 1972-03-10
DK110972A DK137190B (en) 1971-03-12 1972-03-10 Process for the preparation of 6beta-amino-2,2-dimethylpenam-3alpha-carboxylic acid.
AU39848/72A AU470876B2 (en) 1971-03-12 1972-03-10 Improvements in or relating to antibiotics
DE19722211763 DE2211763C2 (en) 1971-03-12 1972-03-10 Process for the preparation of 6β-amino-2,2-dimethylpenam-3α-carboxylic acid
ES400637A ES400637A1 (en) 1971-03-12 1972-03-10 Preparation of antibiotic compounds
CS162272A CS193013B2 (en) 1971-03-12 1972-03-10 Method of producing 6-beta-amino-2,2-dimethylpenam-3-alpha-carboxylic acid
FR7208369A FR2129579A5 (en) 1971-03-12 1972-03-10

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB670871A GB1388265A (en) 1971-03-12 1971-03-12 Preparation of antibiotic compounds

Publications (1)

Publication Number Publication Date
GB1388265A true GB1388265A (en) 1975-03-26

Family

ID=9819332

Family Applications (1)

Application Number Title Priority Date Filing Date
GB670871A Expired GB1388265A (en) 1971-03-12 1971-03-12 Preparation of antibiotic compounds

Country Status (15)

Country Link
JP (1) JPS5421358B1 (en)
AT (1) AT332537B (en)
AU (1) AU470876B2 (en)
BE (1) BE780510A (en)
CA (1) CA1002036A (en)
CH (1) CH571006A5 (en)
CS (1) CS193013B2 (en)
DE (1) DE2211763C2 (en)
DK (1) DK137190B (en)
ES (1) ES400637A1 (en)
FR (1) FR2129579A5 (en)
GB (1) GB1388265A (en)
HU (1) HU163268B (en)
NL (1) NL7203191A (en)
PL (1) PL90110B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003020A1 (en) * 1986-10-31 1988-05-05 Nv Gantax Pharmaceutica Organic acid anhydride and pharmaceutical composition on a prodrug base

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009831A1 (en) * 1989-12-26 1991-07-11 Nova Pharmaceutical Corporation Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR95946E (en) * 1967-10-11 1972-03-10 Koninklijke Gist Spiritus Process for the preparation of aminopenicillanic acid and its derivatives.
DE2062925A1 (en) * 1969-12-26 1971-07-01 President Of Osaka University, Osaka (Japan) 6-aminopenicillanic acid prepn
YU34425B (en) * 1970-06-01 1979-07-10 Galenka Process for preparing 6-aminopenicillanic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003020A1 (en) * 1986-10-31 1988-05-05 Nv Gantax Pharmaceutica Organic acid anhydride and pharmaceutical composition on a prodrug base

Also Published As

Publication number Publication date
DK137190B (en) 1978-01-30
FR2129579A5 (en) 1972-10-27
PL90110B1 (en) 1977-01-31
DK137190C (en) 1978-07-03
CS193013B2 (en) 1979-09-17
AU470876B2 (en) 1973-09-13
AT332537B (en) 1976-10-11
ES400637A1 (en) 1975-01-16
DE2211763A1 (en) 1972-10-05
BE780510A (en) 1972-09-11
CA1002036A (en) 1976-12-21
JPS5421358B1 (en) 1979-07-30
NL7203191A (en) 1972-09-14
ATA205272A (en) 1976-01-15
CH571006A5 (en) 1975-12-31
AU3984872A (en) 1973-09-13
DE2211763C2 (en) 1981-10-08
HU163268B (en) 1973-07-28

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee