GB1388226A - Carboamates of 3,4,5-trimethoxy acetophenone oxime their process of preparation and their therapeutic application - Google Patents
Carboamates of 3,4,5-trimethoxy acetophenone oxime their process of preparation and their therapeutic applicationInfo
- Publication number
- GB1388226A GB1388226A GB4769073A GB4769073A GB1388226A GB 1388226 A GB1388226 A GB 1388226A GB 4769073 A GB4769073 A GB 4769073A GB 4769073 A GB4769073 A GB 4769073A GB 1388226 A GB1388226 A GB 1388226A
- Authority
- GB
- United Kingdom
- Prior art keywords
- trimethoxy
- carboamates
- preparation
- acetophenone oxime
- therapeutic application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LGCDHCGMGDSSIO-GHXNOFRVSA-N (nz)-n-[1-(3,4,5-trimethoxyphenyl)ethylidene]hydroxylamine Chemical compound COC1=CC(C(\C)=N/O)=CC(OC)=C1OC LGCDHCGMGDSSIO-GHXNOFRVSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 230000001670 myorelaxant effect Effects 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1388226 Carbamates of 3,4,5-trimethoxy acetophenoric oxime DELALANDE SA 12 Oct 1973 [17 Oct 1972] 57690/73 Heading C2C Novel compounds I in which R is C 1-4 hydrocarbyl or phenyl optionally substituted by a halogen atom or a C 1-4 alkoxy group are prepared by reacting stoichiometrically an isocyanate R-C=N=O with 3,4,5-trimethoxy-acetophenone oxime. Compounds I have myorelaxant, analgesic anti-inflammatory, sedative, hypotensive, antiarrythmic and anti-cholinergic properties and form with a carrier a pharmaceutical composition which may be administered orally, parenterally or rectally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7236719A FR2202689B1 (en) | 1972-10-17 | 1972-10-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1388226A true GB1388226A (en) | 1975-03-26 |
Family
ID=9105763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4769073A Expired GB1388226A (en) | 1972-10-17 | 1973-10-12 | Carboamates of 3,4,5-trimethoxy acetophenone oxime their process of preparation and their therapeutic application |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS4986340A (en) |
BE (1) | BE805752A (en) |
CA (1) | CA1001163A (en) |
CH (1) | CH581611A5 (en) |
DE (1) | DE2351657A1 (en) |
ES (1) | ES419667A1 (en) |
FR (1) | FR2202689B1 (en) |
GB (1) | GB1388226A (en) |
LU (1) | LU68595A1 (en) |
NL (1) | NL7314307A (en) |
SE (1) | SE403613B (en) |
SU (1) | SU465782A3 (en) |
ZA (1) | ZA737968B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4451286A (en) * | 1977-03-02 | 1984-05-29 | Ciba-Geigy Corporation | Compositions, which influence plant growth and protect plants based on oxime ethers and oxime esters |
WO2008111096A3 (en) * | 2007-03-15 | 2009-09-03 | Sun Pharma Advanced Research Company Ltd | Novel prodrugs |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT365410B (en) * | 1978-08-31 | 1982-01-11 | Ciba Geigy Ag | AGENT FOR THE PROTECTION OF CULTIVATED PLANTS FROM AGGRESSIVE VEGETABLES |
US5124455A (en) * | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
-
1972
- 1972-10-17 FR FR7236719A patent/FR2202689B1/fr not_active Expired
-
1973
- 1973-10-05 BE BE136420A patent/BE805752A/en unknown
- 1973-10-10 LU LU68595A patent/LU68595A1/xx unknown
- 1973-10-12 ZA ZA737968A patent/ZA737968B/en unknown
- 1973-10-12 GB GB4769073A patent/GB1388226A/en not_active Expired
- 1973-10-15 DE DE19732351657 patent/DE2351657A1/en active Pending
- 1973-10-15 CH CH1459773A patent/CH581611A5/xx not_active IP Right Cessation
- 1973-10-16 ES ES419667A patent/ES419667A1/en not_active Expired
- 1973-10-16 SU SU1966881A patent/SU465782A3/en active
- 1973-10-16 JP JP48115383A patent/JPS4986340A/ja active Pending
- 1973-10-16 CA CA183,509A patent/CA1001163A/en not_active Expired
- 1973-10-16 SE SE7314058A patent/SE403613B/en unknown
- 1973-10-17 NL NL7314307A patent/NL7314307A/xx not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4451286A (en) * | 1977-03-02 | 1984-05-29 | Ciba-Geigy Corporation | Compositions, which influence plant growth and protect plants based on oxime ethers and oxime esters |
WO2008111096A3 (en) * | 2007-03-15 | 2009-09-03 | Sun Pharma Advanced Research Company Ltd | Novel prodrugs |
Also Published As
Publication number | Publication date |
---|---|
BE805752A (en) | 1974-04-05 |
SE403613B (en) | 1978-08-28 |
LU68595A1 (en) | 1974-05-09 |
CH581611A5 (en) | 1976-11-15 |
ES419667A1 (en) | 1976-03-16 |
AU6142873A (en) | 1975-04-17 |
JPS4986340A (en) | 1974-08-19 |
CA1001163A (en) | 1976-12-07 |
ZA737968B (en) | 1974-10-30 |
DE2351657A1 (en) | 1974-04-25 |
FR2202689A1 (en) | 1974-05-10 |
SU465782A3 (en) | 1975-03-30 |
NL7314307A (en) | 1974-04-19 |
FR2202689B1 (en) | 1975-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |