GB1388054A - Nati-inflammatory agents - Google Patents

Nati-inflammatory agents

Info

Publication number
GB1388054A
GB1388054A GB2609972A GB2609972A GB1388054A GB 1388054 A GB1388054 A GB 1388054A GB 2609972 A GB2609972 A GB 2609972A GB 2609972 A GB2609972 A GB 2609972A GB 1388054 A GB1388054 A GB 1388054A
Authority
GB
United Kingdom
Prior art keywords
alkyl
benzoxazinones
unsubstituted
compounds
benzothiazinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2609972A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB1388054A publication Critical patent/GB1388054A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1388054 Benzoxazinones, benzothiazinones and their monaoaza-analogues; indolinones E R SQUIBB & SONS Inc 5 June 1972 [28 June 1971] 26099/72 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable salts and N-oxides, wherein X is H, halogen, alkyl, haloalkyl, haloalkoxy, haloalkylthio, alkoxy, OH, NO 2 , NH 2 , alkylthio, alkylsulphonyl, alkanoylamino or mono- or di-alkylamino, wherein each of the (possibly substituted) alkyl groups contains up to 8 carbon atoms; m is 0-4; each A is CH (but one A may be N when n is 1); Y is S, SO, SO 2 or O; n is 0 or 1; R is C 1-8 alkyl, C 3-8 cycloalkyl, X-substituted Ph, pyridyl, thienyl, furyl, naphthyl (C 1-4 -alkyl)phenyl or (C 2-4 - alkenyl)phenyl; Z is CO, C(OH)R<SP>1</SP> or where R<SP>1</SP> is H, vinyl, alkyl or R; and B is a basic N-containing radical. In examples, these compounds (Z=CO) are prepared by reacting RCO 2 Me with the correponding 2-unsubstituted benzoxazinones or -benzothiazinones, or the 3-unsubstituted-indolinones; and may be converted by known methods to those compounds where Z is other than CO. The corresponding 2- and 4- unsubstituted-benzoxazinones and -benzoihiazinones are also prepared. Therapeutic compositions having anti-inflammatory activity comprise compounds of the above formula, and may be administered orally, parenterally or rectally.
GB2609972A 1971-06-28 1972-06-05 Nati-inflammatory agents Expired GB1388054A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15767871A 1971-06-28 1971-06-28
CA143149 1972-05-26

Publications (1)

Publication Number Publication Date
GB1388054A true GB1388054A (en) 1975-03-19

Family

ID=25667058

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2609972A Expired GB1388054A (en) 1971-06-28 1972-06-05 Nati-inflammatory agents

Country Status (5)

Country Link
US (1) US3767653A (en)
CH (1) CH546788A (en)
DE (1) DE2230592A1 (en)
FR (1) FR2147960B1 (en)
GB (1) GB1388054A (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4079135A (en) * 1973-12-13 1978-03-14 Imperial Chemical Industries Limited Morpholine derivatives as antidepressants
US4033951A (en) * 1973-12-13 1977-07-05 Imperial Chemical Industries Limited Morpholine derivative of a 1,4-benzothiazin-3-one
US4006161A (en) * 1973-12-26 1977-02-01 Eli Lilly And Company Thio-substituted 2-oxo-indolines
JPS5121827A (en) * 1974-08-14 1976-02-21 Fuji Photo Film Co Ltd Shashinyokapuraa
US4268301A (en) * 1978-04-17 1981-05-19 Sumitomo Chemical Company, Limited 1,4-Benzothiazines
AU566869B2 (en) * 1982-05-11 1987-11-05 Imperial Chemical Industries Plc Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones
DE3568776D1 (en) * 1984-02-07 1989-04-20 Pfizer 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3579716D1 (en) * 1984-03-19 1990-10-25 Pfizer METHOD FOR PRODUCING 2-OXINDOLE-1-CARBOXAMIDES AND THEIR INTERMEDIATE PRODUCTS.
US4808601A (en) * 1984-09-19 1989-02-28 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
DE3545097A1 (en) * 1985-12-19 1987-07-02 Bayer Ag 1-H-PYRIDO- (3,2-B) (1,4) THIAZINE
US5036099A (en) * 1987-02-02 1991-07-30 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
EP2886541A1 (en) * 2013-12-19 2015-06-24 Sanofi Oxindole derivatives, preparation thereof and therapeutic use in the treatment of AMPK-related diseases
WO2017196970A1 (en) 2016-05-10 2017-11-16 Georgia State University Research Foundation, Inc. Heterocyclic derivatives for the thratment of rsv
CN109562160B (en) 2016-05-10 2022-07-29 乔治亚州立大学研究基金会股份有限公司 Bicyclic fused pyrazole derivatives for the treatment of RSV

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471481A (en) * 1966-03-28 1969-10-07 Squibb & Sons Inc Benzothiazines

Also Published As

Publication number Publication date
FR2147960B1 (en) 1976-03-05
CH546788A (en) 1974-03-15
DE2230592A1 (en) 1973-01-11
US3767653A (en) 1973-10-23
FR2147960A1 (en) 1973-03-11

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Legal Events

Date Code Title Description
CSNS Application of which complete specification have been accepted and published, but patent is not sealed