GB1387782A - Quinoline derivatives their preparation and use - Google Patents
Quinoline derivatives their preparation and useInfo
- Publication number
- GB1387782A GB1387782A GB3586673A GB3586673A GB1387782A GB 1387782 A GB1387782 A GB 1387782A GB 3586673 A GB3586673 A GB 3586673A GB 3586673 A GB3586673 A GB 3586673A GB 1387782 A GB1387782 A GB 1387782A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- saturated
- branched
- straight
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
1387782 Quinoline derivatives SYNTHELABO 27 July 1973 [28 July 1972 4 April 1973 5 May 1973 18 July 1973] 35866/73 Heading C2C Novel compounds of Formula I wherein R is -CH 2 CH = CH 2 or in which A is a straight or branched, saturated or unsaturated aliphatic chain containing 2 to 7 carbon atoms, and R 1 represents either a radical ArA 1 in which Ar is a phenyl radical which is unsubstituted or substituted by 1 to 3 substituents chosen from halogen, halo-methyl, halo-methoxy, halo-methylthio and saturated or unsaturated straight or branched aliphatic radicals containing 1 to 5 carbon atoms, and A 1 is a valence bond or a straight or branched, saturated or unsaturated aliphatic chain containing 1 to 7 carbon atoms, or a radical ArA 2 CO- in which Ar has the meaning given above and A 2 is a valence bond or a straight or branched, saturated or unsaturated aliphatic chain which contains 1 to 7 carbon atoms and which can be interrupted by a hetero-atom or a radical in which Ar has the meaning given above and A 3 is either a valency bond or an aliphatic chain of 1 to 4 carbon atoms and salts thereof are prepared by reaction of compounds of formulae wherein X is halogen or by transesterifying the compound wherein R is -CH 2 CH = CH 2 . Pharmaceutical compositions in conventional forms for oral or rectal administration having anti-inflammatory, analgesic and anti-pyretic activity comprise an above novel compound and a carrier therefor.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7227259A FR2193583B1 (en) | 1972-07-28 | 1972-07-28 | |
| FR7312118A FR2224461B1 (en) | 1972-07-28 | 1973-04-04 | |
| FR7316635A FR2228481B1 (en) | 1972-07-28 | 1973-05-09 | |
| FR7326316A FR2237888B2 (en) | 1972-07-28 | 1973-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1387782A true GB1387782A (en) | 1975-03-19 |
Family
ID=27446189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3586673A Expired GB1387782A (en) | 1972-07-28 | 1973-07-27 | Quinoline derivatives their preparation and use |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5231876B2 (en) |
| AT (1) | AT337189B (en) |
| BE (1) | BE802796A (en) |
| CH (3) | CH582153A5 (en) |
| DE (1) | DE2338260B2 (en) |
| FR (4) | FR2193583B1 (en) |
| GB (1) | GB1387782A (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1369967A (en) * | 1961-10-17 | 1964-08-21 | Roussel Uclaf | New quinoline derivatives and method of preparation |
| FR6103M (en) * | 1967-02-22 | 1968-06-10 |
-
1972
- 1972-07-28 FR FR7227259A patent/FR2193583B1/fr not_active Expired
-
1973
- 1973-04-04 FR FR7312118A patent/FR2224461B1/fr not_active Expired
- 1973-05-09 FR FR7316635A patent/FR2228481B1/fr not_active Expired
- 1973-07-18 FR FR7326316A patent/FR2237888B2/fr not_active Expired
- 1973-07-25 BE BE133868A patent/BE802796A/en unknown
- 1973-07-25 CH CH212176A patent/CH582153A5/xx not_active IP Right Cessation
- 1973-07-25 CH CH1084873A patent/CH577477A5/xx not_active IP Right Cessation
- 1973-07-27 DE DE19732338260 patent/DE2338260B2/en active Granted
- 1973-07-27 GB GB3586673A patent/GB1387782A/en not_active Expired
- 1973-07-28 JP JP48085372A patent/JPS5231876B2/ja not_active Expired
-
1974
- 1974-04-01 CH CH1345676A patent/CH589078A5/xx not_active IP Right Cessation
- 1974-04-04 AT AT284774A patent/AT337189B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2224461B1 (en) | 1976-05-21 |
| DE2338260B2 (en) | 1976-01-29 |
| FR2237888A2 (en) | 1975-02-14 |
| FR2224461A1 (en) | 1974-10-31 |
| CH577477A5 (en) | 1976-07-15 |
| FR2193583A1 (en) | 1974-02-22 |
| CH589078A5 (en) | 1977-06-30 |
| FR2228481A1 (en) | 1974-12-06 |
| CH582153A5 (en) | 1976-11-30 |
| ATA284774A (en) | 1976-10-15 |
| FR2228481B1 (en) | 1976-11-05 |
| FR2237888B2 (en) | 1976-11-12 |
| BE802796A (en) | 1973-11-16 |
| JPS49132089A (en) | 1974-12-18 |
| AT337189B (en) | 1977-06-10 |
| DE2338260A1 (en) | 1974-02-07 |
| JPS5231876B2 (en) | 1977-08-17 |
| FR2193583B1 (en) | 1976-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |