GB1387782A - Quinoline derivatives their preparation and use - Google Patents

Quinoline derivatives their preparation and use

Info

Publication number
GB1387782A
GB1387782A GB3586673A GB3586673A GB1387782A GB 1387782 A GB1387782 A GB 1387782A GB 3586673 A GB3586673 A GB 3586673A GB 3586673 A GB3586673 A GB 3586673A GB 1387782 A GB1387782 A GB 1387782A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
saturated
branched
straight
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3586673A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of GB1387782A publication Critical patent/GB1387782A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • C07D215/44Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

1387782 Quinoline derivatives SYNTHELABO 27 July 1973 [28 July 1972 4 April 1973 5 May 1973 18 July 1973] 35866/73 Heading C2C Novel compounds of Formula I wherein R is -CH 2 CH = CH 2 or in which A is a straight or branched, saturated or unsaturated aliphatic chain containing 2 to 7 carbon atoms, and R 1 represents either a radical ArA 1 in which Ar is a phenyl radical which is unsubstituted or substituted by 1 to 3 substituents chosen from halogen, halo-methyl, halo-methoxy, halo-methylthio and saturated or unsaturated straight or branched aliphatic radicals containing 1 to 5 carbon atoms, and A 1 is a valence bond or a straight or branched, saturated or unsaturated aliphatic chain containing 1 to 7 carbon atoms, or a radical ArA 2 CO- in which Ar has the meaning given above and A 2 is a valence bond or a straight or branched, saturated or unsaturated aliphatic chain which contains 1 to 7 carbon atoms and which can be interrupted by a hetero-atom or a radical in which Ar has the meaning given above and A 3 is either a valency bond or an aliphatic chain of 1 to 4 carbon atoms and salts thereof are prepared by reaction of compounds of formulae wherein X is halogen or by transesterifying the compound wherein R is -CH 2 CH = CH 2 . Pharmaceutical compositions in conventional forms for oral or rectal administration having anti-inflammatory, analgesic and anti-pyretic activity comprise an above novel compound and a carrier therefor.
GB3586673A 1972-07-28 1973-07-27 Quinoline derivatives their preparation and use Expired GB1387782A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR7227259A FR2193583B1 (en) 1972-07-28 1972-07-28
FR7312118A FR2224461B1 (en) 1972-07-28 1973-04-04
FR7316635A FR2228481B1 (en) 1972-07-28 1973-05-09
FR7326316A FR2237888B2 (en) 1972-07-28 1973-07-18

Publications (1)

Publication Number Publication Date
GB1387782A true GB1387782A (en) 1975-03-19

Family

ID=27446189

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3586673A Expired GB1387782A (en) 1972-07-28 1973-07-27 Quinoline derivatives their preparation and use

Country Status (7)

Country Link
JP (1) JPS5231876B2 (en)
AT (1) AT337189B (en)
BE (1) BE802796A (en)
CH (3) CH582153A5 (en)
DE (1) DE2338260B2 (en)
FR (4) FR2193583B1 (en)
GB (1) GB1387782A (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1369967A (en) * 1961-10-17 1964-08-21 Roussel Uclaf New quinoline derivatives and method of preparation
FR6103M (en) * 1967-02-22 1968-06-10

Also Published As

Publication number Publication date
FR2224461B1 (en) 1976-05-21
DE2338260B2 (en) 1976-01-29
FR2237888A2 (en) 1975-02-14
FR2224461A1 (en) 1974-10-31
CH577477A5 (en) 1976-07-15
FR2193583A1 (en) 1974-02-22
CH589078A5 (en) 1977-06-30
FR2228481A1 (en) 1974-12-06
CH582153A5 (en) 1976-11-30
ATA284774A (en) 1976-10-15
FR2228481B1 (en) 1976-11-05
FR2237888B2 (en) 1976-11-12
BE802796A (en) 1973-11-16
JPS49132089A (en) 1974-12-18
AT337189B (en) 1977-06-10
DE2338260A1 (en) 1974-02-07
JPS5231876B2 (en) 1977-08-17
FR2193583B1 (en) 1976-03-05

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee