GB1386566A - Alpha-sulphobenzyl penicillin salts - Google Patents
Alpha-sulphobenzyl penicillin saltsInfo
- Publication number
- GB1386566A GB1386566A GB3147473A GB3147473A GB1386566A GB 1386566 A GB1386566 A GB 1386566A GB 3147473 A GB3147473 A GB 3147473A GB 3147473 A GB3147473 A GB 3147473A GB 1386566 A GB1386566 A GB 1386566A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salts
- amine
- penicillin
- salt
- sulphobenzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Alpha-sulphobenzyl penicillin salts Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 5
- 150000001412 amines Chemical class 0.000 abstract 3
- 229930182555 Penicillin Natural products 0.000 abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
- 229940049954 penicillin Drugs 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6630172A JPS5512435B2 (enExample) | 1972-07-01 | 1972-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1386566A true GB1386566A (en) | 1975-03-12 |
Family
ID=13311838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3147473A Expired GB1386566A (en) | 1972-07-01 | 1973-07-02 | Alpha-sulphobenzyl penicillin salts |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3925357A (enExample) |
| JP (1) | JPS5512435B2 (enExample) |
| AT (1) | AT325206B (enExample) |
| AU (1) | AU469986B2 (enExample) |
| BE (1) | BE801588A (enExample) |
| CA (1) | CA996548A (enExample) |
| CH (1) | CH573435A5 (enExample) |
| CS (1) | CS168036B2 (enExample) |
| DE (1) | DE2332840A1 (enExample) |
| FR (1) | FR2190414B1 (enExample) |
| GB (1) | GB1386566A (enExample) |
| HU (1) | HU166029B (enExample) |
| NL (1) | NL7308048A (enExample) |
| PL (1) | PL92969B1 (enExample) |
| SE (1) | SE402916B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522148U (enExample) * | 1978-07-29 | 1980-02-13 | ||
| MXPA03007349A (es) * | 2001-02-24 | 2003-12-04 | Boehringer Ingelheim Pharma | Derivados de xantina, su preparacion y su empleo como medicamentos. |
| US20030171424A1 (en) * | 2002-03-07 | 2003-09-11 | Lin Ai J. | Intravenous formulation of artelinic acid for treatment of severe and complicated malaria |
| US7407955B2 (en) * | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) * | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| SG174054A1 (en) | 2006-05-04 | 2011-09-29 | Boehringer Ingelheim Int | Polymorphs |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| RU2569749C2 (ru) * | 2007-08-17 | 2015-11-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Производные пурина, предназначенные для применения для лечения заболеваний, связанных с баф (белок-активатор фибробластов) |
| PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| PE20110297A1 (es) * | 2008-08-15 | 2011-05-26 | Boehringer Ingelheim Int | Inhibidores de dpp-4 para la cicatrizacion de heridas |
| RU2011113823A (ru) | 2008-09-10 | 2012-10-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Комбинированная терапия, предназначенная для лечения диабета и связанных с ним состояний |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EP2382216A1 (en) | 2008-12-23 | 2011-11-02 | Boehringer Ingelheim International GmbH | Salt forms of organic compound |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| EP3646859A1 (en) | 2009-11-27 | 2020-05-06 | Boehringer Ingelheim International GmbH | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
| NZ602921A (en) | 2010-05-05 | 2016-01-29 | Boehringer Ingelheim Int | Combination therapy comprising the administration of a glp-1 receptor agonist and a ddp-4 inhibitor |
| KR20230051307A (ko) | 2010-06-24 | 2023-04-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| AU2012285904C1 (en) | 2011-07-15 | 2017-08-31 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| EP4151218A1 (en) | 2012-05-14 | 2023-03-22 | Boehringer Ingelheim International GmbH | Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis |
| US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| EP3468562A1 (en) | 2016-06-10 | 2019-04-17 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1026793A (fr) * | 1949-08-02 | 1953-05-04 | American Cyanamid Co | Procédé de préparation de sels de pénicilline |
| NL6803062A (enExample) * | 1967-03-10 | 1968-09-11 | ||
| US3557094A (en) * | 1968-01-05 | 1971-01-19 | Pfizer & Co C | Substituted alkyl esters of alpha-carboxy aryl penicillins |
| AT290728B (de) * | 1968-09-28 | 1971-05-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung neuer penicilline |
-
1972
- 1972-07-01 JP JP6630172A patent/JPS5512435B2/ja not_active Expired
-
1973
- 1973-06-01 HU HUTA1257A patent/HU166029B/hu unknown
- 1973-06-07 FR FR7320833A patent/FR2190414B1/fr not_active Expired
- 1973-06-08 NL NL7308048A patent/NL7308048A/xx not_active Application Discontinuation
- 1973-06-19 US US371528A patent/US3925357A/en not_active Expired - Lifetime
- 1973-06-25 CS CS4540A patent/CS168036B2/cs unknown
- 1973-06-28 BE BE132836A patent/BE801588A/xx unknown
- 1973-06-28 SE SE7309138A patent/SE402916B/xx unknown
- 1973-06-28 DE DE2332840A patent/DE2332840A1/de active Pending
- 1973-06-29 CA CA175,329A patent/CA996548A/en not_active Expired
- 1973-06-29 AT AT576473A patent/AT325206B/de not_active IP Right Cessation
- 1973-06-29 CH CH955873A patent/CH573435A5/xx not_active IP Right Cessation
- 1973-07-02 GB GB3147473A patent/GB1386566A/en not_active Expired
- 1973-07-02 AU AU57600/73A patent/AU469986B2/en not_active Expired
- 1973-07-02 PL PL1973163783A patent/PL92969B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4925121A (enExample) | 1974-03-06 |
| AT325206B (de) | 1975-10-10 |
| AU469986B2 (en) | 1976-02-26 |
| US3925357A (en) | 1975-12-09 |
| HU166029B (enExample) | 1974-12-28 |
| CH573435A5 (enExample) | 1976-03-15 |
| FR2190414B1 (enExample) | 1976-07-02 |
| CS168036B2 (enExample) | 1976-05-28 |
| FR2190414A1 (enExample) | 1974-02-01 |
| SE402916B (sv) | 1978-07-24 |
| DE2332840A1 (de) | 1974-01-17 |
| CA996548A (en) | 1976-09-07 |
| BE801588A (fr) | 1973-12-28 |
| AU5760073A (en) | 1975-01-09 |
| PL92969B1 (enExample) | 1977-04-30 |
| NL7308048A (enExample) | 1974-01-03 |
| JPS5512435B2 (enExample) | 1980-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |