GB1385652A - Glyceryl 5-aroyl-pyrrole-acetates and propionates and pharmaceutical compositions containing them - Google Patents
Glyceryl 5-aroyl-pyrrole-acetates and propionates and pharmaceutical compositions containing themInfo
- Publication number
- GB1385652A GB1385652A GB281673A GB281673A GB1385652A GB 1385652 A GB1385652 A GB 1385652A GB 281673 A GB281673 A GB 281673A GB 281673 A GB281673 A GB 281673A GB 1385652 A GB1385652 A GB 1385652A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- pyrrole
- alkyl
- toluoyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- -1 5-methylthienyl Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- ILZINBBOCYJKKV-UHFFFAOYSA-N cyanomethyl 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate Chemical compound CN1C(=CC=C1C(C1=CC=C(C=C1)C)=O)CC(=O)OCC#N ILZINBBOCYJKKV-UHFFFAOYSA-N 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- SQNKSNDYVDXUDO-UHFFFAOYSA-N 2-[3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid Chemical compound CC1=CC=C(C=C1)C(=O)C2=CC(=C(N2C)CC(=O)O)CC3COC(O3)(C)C SQNKSNDYVDXUDO-UHFFFAOYSA-N 0.000 abstract 1
- RENMDAKOXSCIGH-UHFFFAOYSA-N Chloroacetonitrile Chemical compound ClCC#N RENMDAKOXSCIGH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004802 cyanophenyl group Chemical group 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003701 inert diluent Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- QGUALMNFRILWRA-UHFFFAOYSA-M tolmetin sodium Chemical compound [Na+].C1=CC(C)=CC=C1C(=O)C1=CC=C(CC([O-])=O)N1C QGUALMNFRILWRA-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21986572A | 1972-01-21 | 1972-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1385652A true GB1385652A (en) | 1975-02-26 |
Family
ID=22821084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB281673A Expired GB1385652A (en) | 1972-01-21 | 1973-01-19 | Glyceryl 5-aroyl-pyrrole-acetates and propionates and pharmaceutical compositions containing them |
Country Status (9)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62289493A (ja) * | 1986-06-09 | 1987-12-16 | ヤマハ発動機株式会社 | 自動二輪車の起動モ−タ取付構造 |
-
0
- BE BE794163D patent/BE794163A/xx not_active IP Right Cessation
-
1973
- 1973-01-15 AU AU51094/73A patent/AU476415B2/en not_active Expired
- 1973-01-17 CH CH64973A patent/CH577965A5/xx not_active IP Right Cessation
- 1973-01-18 FR FR7301767A patent/FR2183661B1/fr not_active Expired
- 1973-01-19 GB GB281673A patent/GB1385652A/en not_active Expired
- 1973-01-19 AT AT47173A patent/AT323149B/de not_active IP Right Cessation
- 1973-01-19 CA CA161,628A patent/CA1016949A/en not_active Expired
- 1973-01-19 DE DE2302670A patent/DE2302670A1/de active Pending
- 1973-01-22 JP JP48009396A patent/JPS5825671B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU5109473A (en) | 1974-07-18 |
| JPS4880554A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-10-29 |
| AU476415B2 (en) | 1976-09-23 |
| FR2183661A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-12-21 |
| FR2183661B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-11-21 |
| AT323149B (de) | 1975-06-25 |
| BE794163A (fr) | 1973-07-17 |
| CH577965A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-07-30 |
| CA1016949A (en) | 1977-09-06 |
| DE2302670A1 (de) | 1973-07-26 |
| JPS5825671B2 (ja) | 1983-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |