GB1384991A - Triazoloazepine derivatives their preparation and their use as pharmaceuticals - Google Patents
Triazoloazepine derivatives their preparation and their use as pharmaceuticalsInfo
- Publication number
- GB1384991A GB1384991A GB59973A GB59973A GB1384991A GB 1384991 A GB1384991 A GB 1384991A GB 59973 A GB59973 A GB 59973A GB 59973 A GB59973 A GB 59973A GB 1384991 A GB1384991 A GB 1384991A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- hydrogen
- formula
- group
- jan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title 1
- JVCUBYFUMAWSBI-UHFFFAOYSA-N triazolo[4,5-b]azepine Chemical class N1=CC=CC=C2N=NN=C21 JVCUBYFUMAWSBI-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 alkyl carbazate Chemical compound 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fodder In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22040572A | 1972-01-24 | 1972-01-24 | |
| US30711372A | 1972-11-16 | 1972-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1384991A true GB1384991A (en) | 1975-02-26 |
Family
ID=26914852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB59973A Expired GB1384991A (en) | 1972-01-24 | 1973-01-04 | Triazoloazepine derivatives their preparation and their use as pharmaceuticals |
Country Status (11)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015738A (en) * | 1989-08-07 | 1991-05-14 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
| US5189161A (en) * | 1989-08-07 | 1993-02-23 | Hoechst Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
| US5607929A (en) * | 1991-05-02 | 1997-03-04 | Glaxo Wellcome Inc. | Antiviral dibenzothiazepinone derivatives |
-
0
- BE BE794452D patent/BE794452A/xx unknown
-
1973
- 1973-01-04 GB GB59973A patent/GB1384991A/en not_active Expired
- 1973-01-11 IL IL48451A patent/IL48451A/xx unknown
- 1973-01-11 IL IL41277A patent/IL41277A/en unknown
- 1973-01-12 DE DE2301399A patent/DE2301399A1/de active Pending
- 1973-01-12 AR AR246102A patent/AR199470A1/es active
- 1973-01-15 CA CA161,316A patent/CA984389A/en not_active Expired
- 1973-01-22 NL NL7300874A patent/NL7300874A/xx not_active Application Discontinuation
- 1973-01-23 FR FR7302227A patent/FR2181681B1/fr not_active Expired
- 1973-01-23 CH CH94573A patent/CH603653A5/xx not_active IP Right Cessation
- 1973-01-23 CH CH1287776A patent/CH598266A5/xx not_active IP Right Cessation
- 1973-01-23 JP JP48009232A patent/JPS4881897A/ja active Pending
- 1973-06-08 PH PH14238*[A patent/PH9908A/en unknown
-
1975
- 1975-11-11 IL IL48451A patent/IL48451A0/xx unknown
-
1976
- 1976-01-13 PH PH17967A patent/PH12152A/en unknown
- 1976-01-13 PH PH17966A patent/PH11951A/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015738A (en) * | 1989-08-07 | 1991-05-14 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
| US5189161A (en) * | 1989-08-07 | 1993-02-23 | Hoechst Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
| US5607929A (en) * | 1991-05-02 | 1997-03-04 | Glaxo Wellcome Inc. | Antiviral dibenzothiazepinone derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| PH12152A (en) | 1978-11-10 |
| IL48451A (en) | 1979-10-31 |
| IL48451A0 (en) | 1976-01-30 |
| AR199470A1 (es) | 1974-09-09 |
| NL7300874A (enrdf_load_html_response) | 1973-07-26 |
| PH11951A (en) | 1978-09-20 |
| BE794452A (fr) | 1973-07-24 |
| IL41277A0 (en) | 1973-03-30 |
| JPS4881897A (enrdf_load_html_response) | 1973-11-01 |
| CH603653A5 (enrdf_load_html_response) | 1978-08-31 |
| IL41277A (en) | 1977-05-31 |
| FR2181681A1 (enrdf_load_html_response) | 1973-12-07 |
| FR2181681B1 (enrdf_load_html_response) | 1976-07-02 |
| DE2301399A1 (de) | 1973-08-02 |
| CA984389A (en) | 1976-02-24 |
| CH598266A5 (enrdf_load_html_response) | 1978-04-28 |
| PH9908A (en) | 1976-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |