GB1384991A - Triazoloazepine derivatives their preparation and their use as pharmaceuticals - Google Patents

Triazoloazepine derivatives their preparation and their use as pharmaceuticals

Info

Publication number
GB1384991A
GB1384991A GB59973A GB59973A GB1384991A GB 1384991 A GB1384991 A GB 1384991A GB 59973 A GB59973 A GB 59973A GB 59973 A GB59973 A GB 59973A GB 1384991 A GB1384991 A GB 1384991A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
formula
group
jan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB59973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1384991A publication Critical patent/GB1384991A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fodder In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1384991 Triazoloazepines UPJOHN CO 4 Jan 1973 [24 Jan 1972 16 Nov 1972] 599/73 Heading C2C The invention comprises compounds having the general formula wherein X is oxygen, sulphur, the group in which R 5 and R 6 are each hydrogen of C 1-3 alkyl, >N-R 1 in which R 1 is hydrogen, C 1-3 alkyl, in which n is 1-4 and R is C 1-3 alkyl, or R 1 is -CnH 2 nNR 7 R 8 or CH 2 C # CNR 7 R 8 in which R 7 and R 8 are each hydrogen or C 1-3 alkyl or together form a pyrrolidino or piperidino group; R 2 has the same meaning as R 1 ; and R 3 and R 4 are each hydrogen, halogen, amino, nitro, cyano, C 1-3 alkyl or trifluoromethyl, or alkoxy, alkylthio, alkyl sulphinyl, alkyl sulphonyl, alkanoylamino or dialkylamino in which the alkyl groups have 1-3 carbon atoms and acid addition salts thereof. They may be prepared by treating a compound of the formula with an alkyl carbazate of the formula where the alkyl group has 1 to 3 carbon atoms, to give a compound of the formula and treating II with R 2 Cl, R 2 Br or R 2 I as an alkylating agent in the presence of base. The compounds of the invention exhibit antidepressant activity and may be administered in admixture with conventional diluents or carriers either orally, parenterally or rectally.
GB59973A 1972-01-24 1973-01-04 Triazoloazepine derivatives their preparation and their use as pharmaceuticals Expired GB1384991A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22040572A 1972-01-24 1972-01-24
US30711372A 1972-11-16 1972-11-16

Publications (1)

Publication Number Publication Date
GB1384991A true GB1384991A (en) 1975-02-26

Family

ID=26914852

Family Applications (1)

Application Number Title Priority Date Filing Date
GB59973A Expired GB1384991A (en) 1972-01-24 1973-01-04 Triazoloazepine derivatives their preparation and their use as pharmaceuticals

Country Status (11)

Country Link
JP (1) JPS4881897A (en)
AR (1) AR199470A1 (en)
BE (1) BE794452A (en)
CA (1) CA984389A (en)
CH (2) CH598266A5 (en)
DE (1) DE2301399A1 (en)
FR (1) FR2181681B1 (en)
GB (1) GB1384991A (en)
IL (3) IL48451A (en)
NL (1) NL7300874A (en)
PH (3) PH9908A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015738A (en) * 1989-08-07 1991-05-14 Hoechst-Roussel Pharmaceuticals Inc. Benzo(b)pyrrolobenzodiazepines
US5189161A (en) * 1989-08-07 1993-02-23 Hoechst Roussel Pharmaceuticals Inc. Benzo(b)pyrrolobenzodiazepines
US5607929A (en) * 1991-05-02 1997-03-04 Glaxo Wellcome Inc. Antiviral dibenzothiazepinone derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015738A (en) * 1989-08-07 1991-05-14 Hoechst-Roussel Pharmaceuticals Inc. Benzo(b)pyrrolobenzodiazepines
US5189161A (en) * 1989-08-07 1993-02-23 Hoechst Roussel Pharmaceuticals Inc. Benzo(b)pyrrolobenzodiazepines
US5607929A (en) * 1991-05-02 1997-03-04 Glaxo Wellcome Inc. Antiviral dibenzothiazepinone derivatives

Also Published As

Publication number Publication date
IL41277A0 (en) 1973-03-30
FR2181681A1 (en) 1973-12-07
IL41277A (en) 1977-05-31
PH9908A (en) 1976-06-08
FR2181681B1 (en) 1976-07-02
NL7300874A (en) 1973-07-26
BE794452A (en) 1973-07-24
CA984389A (en) 1976-02-24
IL48451A0 (en) 1976-01-30
AR199470A1 (en) 1974-09-09
IL48451A (en) 1979-10-31
CH598266A5 (en) 1978-04-28
DE2301399A1 (en) 1973-08-02
JPS4881897A (en) 1973-11-01
PH11951A (en) 1978-09-20
CH603653A5 (en) 1978-08-31
PH12152A (en) 1978-11-10

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee