GB1384488A - Stabilized n6-2,0-dibutyryladenosine-3,5,-cyclic phosphate salts and production thereof - Google Patents

Stabilized n6-2,0-dibutyryladenosine-3,5,-cyclic phosphate salts and production thereof

Info

Publication number
GB1384488A
GB1384488A GB4695673A GB4695673A GB1384488A GB 1384488 A GB1384488 A GB 1384488A GB 4695673 A GB4695673 A GB 4695673A GB 4695673 A GB4695673 A GB 4695673A GB 1384488 A GB1384488 A GB 1384488A
Authority
GB
United Kingdom
Prior art keywords
moisture content
drying
weight
cyclic phosphate
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4695673A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Publication of GB1384488A publication Critical patent/GB1384488A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1384488 Stabilized salts of N<SP>6</SP>-2<SP>1</SP>,0-dibutyryl adenosine 3<SP>1</SP>,5<SP>1</SP>-cyclic phosphate YAMASA SHOYU KK 8 Oct 1973 [9 Oct 1972] 46956/73 Heading C2P The invention comprises stabilized alkali metal and ammonium salts, in solid powder form, of N<SP>6</SP>-2<SP>1</SP>,0-dibutyryl adenosine-3<SP>1</SP>,5<SP>1</SP> cyclic phosphate having a maximum moisture content of 3À0% by weight. They may be obtained by subjecting a corresponding salt having a moisture content exceeding 3% by weight to a drying process to reduce the moisture content to the maximum 3% by weight. Drying may be effected by use of a desiccant, e.g. under reduced pressure or vacuum, by freeze drying, vacuum-spray drying or by azeotropic dehydration. The drying should generally be carried out at a temperature not exceeding 30‹ C. to avoid risk of decomposition. Specified desiccants are P 2 O 5 , CaCl 2 , SiO 2 and H 2 SO 4 . Absolute hydrophylic organic solvents such as alcohols, acetone and dioxane may also be used to effect dehydration. A desirable method comprises first drying to a certain moisture content, e.g. from 3 to 10%, or less, e.g. by freeze drying, and then (if necessary), lowering the moisture content to 3% or less by use of a desiccant. Examples are given (a) for reducing the moisture content of the sodium salt to 0À88% and then to allow the moisture content to rise to 1À86%, 2À57% and 6À37% respectively the latter being for comparative purposes, and (b) for reducing the moisture content of the potassium salt first by freeze-drying and then by P 2 O 5 desiccation to 0À63% and then to allow the moisture content to rise to 1À64, 2À36 and 5À87% respectively, the latter again being for comparative purposes. The products have pharmacological uses.
GB4695673A 1972-10-09 1973-10-08 Stabilized n6-2,0-dibutyryladenosine-3,5,-cyclic phosphate salts and production thereof Expired GB1384488A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP47100642A JPS5134443B2 (en) 1972-10-09 1972-10-09

Publications (1)

Publication Number Publication Date
GB1384488A true GB1384488A (en) 1975-02-19

Family

ID=14279465

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4695673A Expired GB1384488A (en) 1972-10-09 1973-10-08 Stabilized n6-2,0-dibutyryladenosine-3,5,-cyclic phosphate salts and production thereof

Country Status (5)

Country Link
JP (1) JPS5134443B2 (en)
DE (1) DE2350228C3 (en)
FR (1) FR2202091B1 (en)
GB (1) GB1384488A (en)
NL (1) NL151381B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1441706A (en) * 1973-04-06 1976-07-07 Yamasa Shoyu Kk Crystalline monosodium n6, 2-o-dibutyryl-adenosine-3-5-cyclic monophosphate and production thereof
JPS50142595A (en) * 1974-05-14 1975-11-17
JP2740362B2 (en) * 1991-02-12 1998-04-15 ヤマサ醤油株式会社 Stable solid 2-octynyl adenosine and process for its preparation

Also Published As

Publication number Publication date
NL7313793A (en) 1974-04-11
DE2350228C3 (en) 1975-11-06
DE2350228B2 (en) 1975-03-27
FR2202091B1 (en) 1977-05-27
JPS5134443B2 (en) 1976-09-27
DE2350228A1 (en) 1974-05-02
NL151381B (en) 1976-11-15
FR2202091A1 (en) 1974-05-03
JPS4955814A (en) 1974-05-30

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19921008