GB1383773A - Piperidino-alkyl phenothiazine derivatives - Google Patents
Piperidino-alkyl phenothiazine derivativesInfo
- Publication number
- GB1383773A GB1383773A GB2277272A GB2277272A GB1383773A GB 1383773 A GB1383773 A GB 1383773A GB 2277272 A GB2277272 A GB 2277272A GB 2277272 A GB2277272 A GB 2277272A GB 1383773 A GB1383773 A GB 1383773A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reaction
- compound
- alkyl
- prepared
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- QEYMMOKECZBKAC-UHFFFAOYSA-N 3-chloropropanoic acid Chemical compound OC(=O)CCCl QEYMMOKECZBKAC-UHFFFAOYSA-N 0.000 abstract 1
- URPDRZNHQSGPRP-UHFFFAOYSA-N 3-heptoxypropanoic acid Chemical compound CCCCCCCOCCC(O)=O URPDRZNHQSGPRP-UHFFFAOYSA-N 0.000 abstract 1
- ZPMKVKFUGRQXKN-UHFFFAOYSA-N 3-heptoxypropanoyl chloride Chemical compound CCCCCCCOCCC(Cl)=O ZPMKVKFUGRQXKN-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1383773 Piperidinoalkyl - phenothiazines ROUSSEL UCLAF 15 May 1972 [14 May 1971 (2)] 22772/72 Heading C2C Novel compounds I (X is H, Cl, CF 3 , OCH 3 or SCH 3 ; B and R each represents H or 1-4 C alkyl; Z<SP>1</SP> is H or Z, Z being 1-10 C alkyl ; p is 0 or 1; n is 0, 1 or 2 and A is H, -COR 1 or -COOR 2 , R 1 being polymethoxyphenyl or 1-18 C alkyl optionally containing a double bond or an oxy radical -O- and R 2 being 1-15 C straight chain alkyl), and non-toxic acid addition salts thereof are prepared by reaction of a compound II Y is Cl or Br), with a compound III or by reaction of a compound I, in which A is H, with R 1 COCl or ClCOOR 2 . Compounds III are described and claimed in Specification 1,383,774. 3 - Heptyloxy - propionic acid is prepared by reaction of heptanol with 3-chloropropionic acid. 3-Heptyloxypropionyl chloride is prepared by reaction of the free acid with thionyl chloride. Pharmaceutical compositions having neuroleptic, anti-histamine, analgesic and spasmolytic properties comprise a compound I or a non-toxic salt thereof together with a suitable carrier or excipient and are aministered orally, rectally, parenterally or topically.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR717117509A FR2137149B1 (en) | 1971-05-14 | 1971-05-14 | |
FR7117510A FR2137150B1 (en) | 1971-05-14 | 1971-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1383773A true GB1383773A (en) | 1974-02-12 |
Family
ID=26216390
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3172274A Expired GB1383774A (en) | 1971-05-14 | 1972-05-15 | 4-substituted piperidine derivatives |
GB2277272A Expired GB1383773A (en) | 1971-05-14 | 1972-05-15 | Piperidino-alkyl phenothiazine derivatives |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3172274A Expired GB1383774A (en) | 1971-05-14 | 1972-05-15 | 4-substituted piperidine derivatives |
Country Status (13)
Country | Link |
---|---|
JP (2) | JPS5118958B1 (en) |
AU (1) | AU461649B2 (en) |
BE (1) | BE783411A (en) |
CH (1) | CH553215A (en) |
DE (2) | DE2264903C3 (en) |
DK (1) | DK142318B (en) |
FI (1) | FI55657C (en) |
FR (2) | FR2137150B1 (en) |
GB (2) | GB1383774A (en) |
IL (1) | IL39296A (en) |
NL (1) | NL175824C (en) |
NO (1) | NO135365C (en) |
SE (2) | SE405973B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002050050A1 (en) * | 2000-12-19 | 2002-06-27 | Ucb, S.A. | 2-(2-(4-((2r)-2-methyl-3-(10h-phenothiazin-10-yl)propyl)-1-piperazinyl)-ethoxy)ethanol, process for the preparation thereof, pharmaceutical compositions containing said compound and therapeutic uses thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0621267A1 (en) * | 1993-04-07 | 1994-10-26 | Shell Internationale Researchmaatschappij B.V. | Spiropiperidine derivatives and their use as fungicides |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1344593A (en) * | 1961-11-25 | 1963-11-29 | Boehringer & Soehne Gmbh | Process for the preparation of novel alkoxy-piperidine derivatives and their salts |
-
1971
- 1971-05-14 FR FR7117510A patent/FR2137150B1/fr not_active Expired
- 1971-05-14 FR FR717117509A patent/FR2137149B1/fr not_active Expired
-
1972
- 1972-04-25 IL IL39296A patent/IL39296A/en unknown
- 1972-04-27 CH CH629072A patent/CH553215A/en not_active IP Right Cessation
- 1972-05-09 SE SE7206146A patent/SE405973B/en unknown
- 1972-05-09 FI FI1305/72A patent/FI55657C/en active
- 1972-05-10 DE DE2264903A patent/DE2264903C3/en not_active Expired
- 1972-05-10 DE DE2222931A patent/DE2222931C3/en not_active Expired
- 1972-05-12 BE BE783411A patent/BE783411A/en not_active IP Right Cessation
- 1972-05-12 AU AU42226/72A patent/AU461649B2/en not_active Expired
- 1972-05-12 NO NO1690/72A patent/NO135365C/en unknown
- 1972-05-13 JP JP47046917A patent/JPS5118958B1/ja active Pending
- 1972-05-15 DK DK240672AA patent/DK142318B/en not_active IP Right Cessation
- 1972-05-15 NL NLAANVRAGE7206504,A patent/NL175824C/en not_active IP Right Cessation
- 1972-05-15 GB GB3172274A patent/GB1383774A/en not_active Expired
- 1972-05-15 GB GB2277272A patent/GB1383773A/en not_active Expired
-
1975
- 1975-05-06 SE SE7505250A patent/SE418964B/en unknown
- 1975-11-25 JP JP50140299A patent/JPS5248988B2/ja not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002050050A1 (en) * | 2000-12-19 | 2002-06-27 | Ucb, S.A. | 2-(2-(4-((2r)-2-methyl-3-(10h-phenothiazin-10-yl)propyl)-1-piperazinyl)-ethoxy)ethanol, process for the preparation thereof, pharmaceutical compositions containing said compound and therapeutic uses thereof |
Also Published As
Publication number | Publication date |
---|---|
IL39296A0 (en) | 1972-06-28 |
NL175824B (en) | 1984-08-01 |
DE2222931C3 (en) | 1978-07-06 |
AU461649B2 (en) | 1975-06-05 |
DE2264903A1 (en) | 1975-08-28 |
FI55657C (en) | 1979-09-10 |
FR2137150A1 (en) | 1972-12-29 |
NL7206504A (en) | 1972-11-16 |
CH553215A (en) | 1974-08-30 |
BE783411A (en) | 1972-11-13 |
JPS5248988B2 (en) | 1977-12-14 |
DE2222931A1 (en) | 1972-11-30 |
DK142318C (en) | 1981-03-02 |
SE418964B (en) | 1981-07-06 |
DE2264903B2 (en) | 1981-02-19 |
FR2137149A1 (en) | 1972-12-29 |
DK142318B (en) | 1980-10-13 |
FI55657B (en) | 1979-05-31 |
SE7505250L (en) | 1975-05-06 |
NO135365C (en) | 1977-03-30 |
FR2137150B1 (en) | 1975-01-17 |
NO135365B (en) | 1976-12-20 |
FR2137149B1 (en) | 1973-05-11 |
SE405973B (en) | 1979-01-15 |
DE2222931B2 (en) | 1977-11-10 |
AU4222672A (en) | 1973-12-06 |
JPS5191267A (en) | 1976-08-10 |
DE2264903C3 (en) | 1981-12-17 |
NL175824C (en) | 1985-01-02 |
JPS5118958B1 (en) | 1976-06-14 |
GB1383774A (en) | 1974-02-12 |
IL39296A (en) | 1976-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |